2023
Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease
Prokopiou P, Engels-Domínguez N, Schultz A, Sepulcre J, Koops E, Papp K, Marshall G, Normandin M, El Fakhri G, Rentz D, Sperling R, Johnson K, Jacobs H. Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease. Neurology 2023, 101: e1206-e1217. PMID: 37491329, PMCID: PMC10516269, DOI: 10.1212/wnl.0000000000207646.Peer-Reviewed Original ResearchConceptsLC activityMemory declineLocus coeruleusCognitive declineEC tauHarvard Aging Brain StudyHuman neuroimaging studiesSteeper memory declineNoradrenergic brainstem nucleiLongitudinal cognitive dataFunctional MRI dataTau depositionAging Brain StudyPreclinical Alzheimer's diseaseTau progressionCortical tau depositionElevated beta-amyloidInterventions promoting resilienceMild cognitive impairmentExecutive dysfunctionExecutive functionNeuroimaging studiesTau spreadingTemporal cortexCognitive composite
2003
MRI-Guided SPECT Perfusion Measures and Volumetric MRI in Prodromal Alzheimer Disease
El Fakhri G, Kijewski M, Johnson K, Syrkin G, Killiany R, Becker J, Zimmerman R, Albert M. MRI-Guided SPECT Perfusion Measures and Volumetric MRI in Prodromal Alzheimer Disease. JAMA Neurology 2003, 60: 1066-1072. PMID: 12925361, DOI: 10.1001/archneur.60.8.1066.Peer-Reviewed Original ResearchConceptsRostral anterior cingulateCaudal anterior cingulateMagnetic resonance imagingAnterior cingulateSuperior temporal sulcusPosterior cingulateBasal forebrainTemporal hornEntorhinal cortexTemporal sulcusGroup differencesMemory problemsNondemented patientsFollow-upQuantitative single-photon emissionProdromal phase of Alzheimer's diseaseReceiver operating characteristic curve analysisYears of follow-upAlzheimer's diseasePhase of Alzheimer's diseaseCharacteristic curve analysisVolumetric magnetic resonance imagingMagnetic resonance imaging analysisMagnetic resonance imaging measuresSPECT analysis