2022
VoxelHop: Successive Subspace Learning for ALS Disease Classification Using Structural MRI
Liu X, Xing F, Yang C, Kuo C, Babu S, Fakhri G, Jenkins T, Woo J. VoxelHop: Successive Subspace Learning for ALS Disease Classification Using Structural MRI. IEEE Journal Of Biomedical And Health Informatics 2022, 26: 1128-1139. PMID: 34339378, PMCID: PMC8807766, DOI: 10.1109/jbhi.2021.3097735.Peer-Reviewed Original ResearchConceptsConvolutional neural networkLearning modelsDimension reductionSubspace learning modelConcatenation of featuresState-of-the-artUnsupervised dimension reductionDeep learning modelsMedical image dataSupervised dimension reductionImage dataClassification of amyotrophic lateral sclerosisSubspace learningClassification taskDeep learningDataset sizeNeural networkSubspace approximationMemory requirementsTraining datasetClassification approachAUC scoreAccurate classificationDatasetExperimental results
2021
Speech intelligibility loss due to amyotrophic lateral sclerosis: the effect of tongue movement reduction on vowel and consonant acoustic features
Rong P, Usler E, Rowe L, Allison K, Woo J, Fakhri G, Green J. Speech intelligibility loss due to amyotrophic lateral sclerosis: the effect of tongue movement reduction on vowel and consonant acoustic features. Clinical Linguistics & Phonetics 2021, 35: 1091-1112. PMID: 33427505, DOI: 10.1080/02699206.2020.1868021.Peer-Reviewed Original ResearchMeSH KeywordsAcousticsAmyotrophic Lateral SclerosisDysarthriaHumansMovementSpeech AcousticsSpeech IntelligibilitySpeech Production MeasurementTongueConceptsTarget wordsIntelligence declineSpeech intelligibilityPredictors of speech intelligibilityDysarthria secondary to amyotrophic lateral sclerosisMotor performanceHealthy controlsReduced speech intelligibilityAcoustic featuresPhonetic distinctionsSpeech soundsRobust predictorsTongue movementDisease-related changesSpeech intelligibility declinesAmyotrophic lateral sclerosisTongue dynamicsMeasurement typesReduced rangeImpaired tongue movementMovement reductionWordsTongue bladeVowelsSpeech
2018
Magnetic resonance imaging based anatomical assessment of tongue impairment due to amyotrophic lateral sclerosis: A preliminary study
Lee E, Xing F, Ahn S, Reese T, Wang R, Green J, Atassi N, Wedeen V, El Fakhri G, Woo J. Magnetic resonance imaging based anatomical assessment of tongue impairment due to amyotrophic lateral sclerosis: A preliminary study. The Journal Of The Acoustical Society Of America 2018, 143: el248-el254. PMID: 29716267, PMCID: PMC5895467, DOI: 10.1121/1.5030134.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAmyotrophic Lateral SclerosisCase-Control StudiesDiffusion Tensor ImagingFemaleHumansMaleMiddle AgedTongue DiseasesConceptsDiffusion tensor imagingHigh-resolution magnetic resonance imagingMagnetic resonance imagingResonance imagingEffects of amyotrophic lateral sclerosisAmyotrophic lateral sclerosisTensor imagingAmyotrophic lateral sclerosis patientsFiber connectionsSpeechNeurological disordersLateral sclerosis