2015
Monitoring proton therapy with PET
Paganetti H, Fakhri G. Monitoring proton therapy with PET. British Journal Of Radiology 2015, 88: 20150173. PMID: 25989699, PMCID: PMC4628541, DOI: 10.1259/bjr.20150173.Peer-Reviewed Original ResearchMeSH KeywordsHumansMonte Carlo MethodPositron-Emission TomographyProton TherapyRadiation MonitoringRadiotherapy DosageUncertaintyConceptsPatient set-upDose conformityDose shapingInterfractional changesProton beamBeam deliveryDose calculationProton therapyTumor coveragePhotonic techniquesTreatment volumeTotal energyPatient anatomyBeamRadiation therapyProtonPatientsTherapyReduced total energyDoseSet-upRangeCalculationsRadiationEnergyMapping 15O Production Rate for Proton Therapy Verification
Grogg K, Alpert N, Zhu X, Min C, Testa M, Winey B, Normandin M, Shih H, Paganetti H, Bortfeld T, Fakhri G. Mapping 15O Production Rate for Proton Therapy Verification. International Journal Of Radiation Oncology • Biology • Physics 2015, 92: 453-459. PMID: 25817530, PMCID: PMC4431894, DOI: 10.1016/j.ijrobp.2015.01.023.Peer-Reviewed Original ResearchConceptsDecay constantProton treatment planningMonte Carlo predictionsProton therapyPhantom materialTreatment deliveryPhantomThigh activityPositron emission tomographyProduction rateDynamic PET measurementsTreatment planningRabbit thigh muscleClearance rateProtonIsotopesChanges due to therapyRadionuclide speciesOxygen-15ConstantDecayImaging targetsMontePositronEffects of perfusion
2014
A Recommendation on How to Analyze In-Room PET for In Vivo Proton Range Verification Using a Distal PET Surface Method
Min C, Zhu X, Grogg K, Fakhri G, Winey B, Paganetti H. A Recommendation on How to Analyze In-Room PET for In Vivo Proton Range Verification Using a Distal PET Surface Method. Technology In Cancer Research & Treatment 2014, 14: 320-325. PMID: 25246517, PMCID: PMC4898041, DOI: 10.1177/1533034614547457.Peer-Reviewed Original ResearchConceptsIn vivo range verificationIn-room positron emission tomographyRange verificationBeam passageIn vivo proton range verificationIn-roomIn-room PET scannerPositron emission tomography activityProton beam rangeProton range verificationSingle-field treatmentsProton beam deliveryAverage range differencesBeam rangeBeam deliveryPET scannerRoot-mean-square deviationPositron emission tomographyBeamRange differencesLevel surfaceActive lineActivity levelsLocal variationsTreatment course
2013
Determination of elemental tissue composition following proton treatment using positron emission tomography
Cho J, Ibbott G, Gillin M, Gonzalez-Lepera C, Min C, Zhu X, Fakhri G, Paganetti H, Mawlawi O. Determination of elemental tissue composition following proton treatment using positron emission tomography. Physics In Medicine And Biology 2013, 58: 3815-3835. PMID: 23681070, PMCID: PMC3763743, DOI: 10.1088/0031-9155/58/11/3815.Peer-Reviewed Original ResearchConceptsIn-room PET scannerProton treatmentSOBP beamPET scannerMonte Carlo simulationsTissue elemental compositionComposite decay curvePristine Bragg peakProton treatment planningIn-roomElemental tissue compositionCarlo simulationsDecay curvesRange verificationMonoenergetic beamsBeam rangeProton dosePhantom sectionsEmitted positronsPositron emission tomographyProton therapyBragg peakPhantom compositionDelivered dosePositron emission tomography imagingClinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy
Min C, Zhu X, Winey B, Grogg K, Testa M, Fakhri G, Bortfeld T, Paganetti H, Shih H. Clinical Application of In-Room Positron Emission Tomography for In Vivo Treatment Monitoring in Proton Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2013, 86: 183-189. PMID: 23391817, PMCID: PMC3640852, DOI: 10.1016/j.ijrobp.2012.12.010.Peer-Reviewed Original ResearchConceptsIn-room positron emission tomographyProton therapyIn-roomPositron emission tomography scanIn-room PET scannerPassive scattering proton therapyShapes of target volumesPositron emission tomographyMC predictionBeam range uncertaintiesMeasured PET imagesMonte CarloProton radiation therapyLocal elemental compositionBiological washoutScan timeTreatment headTreatment verificationRange uncertaintiesTarget volumePET scan timePET scannerPET systemComputed tomographyMC resultsProton Therapy Verification with PET Imaging
Zhu X, Fakhri G. Proton Therapy Verification with PET Imaging. Theranostics 2013, 3: 731-740. PMID: 24312147, PMCID: PMC3840408, DOI: 10.7150/thno.5162.Peer-Reviewed Original Research
2011
Monitoring proton radiation therapy with in-room PET imaging
Zhu X, España S, Daartz J, Liebsch N, Ouyang J, Paganetti H, Bortfeld T, Fakhri G. Monitoring proton radiation therapy with in-room PET imaging. Physics In Medicine And Biology 2011, 56: 4041-4057. PMID: 21677366, PMCID: PMC3141290, DOI: 10.1088/0031-9155/56/13/019.Peer-Reviewed Original ResearchConceptsIn-room positron emission tomographyIn-roomProton therapy treatment roomPositron emission tomography systemProton range verificationSoft tissue-equivalent materialMonte Carlo predictionsTissue-equivalent materialsPositron emission tomography acquisition timesProton radiation therapyPositron emission tomographyBiological washoutRange verificationProton therapyList-modeActivity distribution patternsPhantom studyTreatment roomPET acquisitionSoft tissue regionsIn vivo verificationDeep-siteOff-line modalityPositron emission tomography dataAdenoid cystic carcinoma