2019
Quantification of PET Myocardial Blood Flow
Pelletier-Galarneau M, Martineau P, El Fakhri G. Quantification of PET Myocardial Blood Flow. Current Cardiology Reports 2019, 21: 11. PMID: 30815744, DOI: 10.1007/s11886-019-1096-x.Peer-Reviewed Original ResearchConceptsPositron emission tomographyMyocardial blood flowMyocardial flow reserveMicrovascular dysfunctionEvaluation of cardiac allograft vasculopathyAssessment of coronary microvascular dysfunctionFlow reserveHyperemic myocardial blood flowFlow quantificationCardiac allograft vasculopathyMarkers of disease severityCoronary microvascular dysfunctionImprove risk stratificationQuantification of myocardial blood flowFractional flow reserveMyocardial blood flow quantificationAllograft vasculopathyPrognostic valueRisk stratificationEpicardial diseaseAcademic centersReviewThe aimClinical aspectsEmission tomographyBlood flow
2014
Towards coronary plaque imaging using simultaneous PET-MR: a simulation study
Petibon Y, Fakhri G, Nezafat R, Johnson N, Brady T, Ouyang J. Towards coronary plaque imaging using simultaneous PET-MR: a simulation study. Physics In Medicine And Biology 2014, 59: 1203-1222. PMID: 24556608, PMCID: PMC4061607, DOI: 10.1088/0031-9155/59/5/1203.Peer-Reviewed Original ResearchMeSH KeywordsComputer SimulationCoronary AngiographyCoronary StenosisHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance AngiographyModels, CardiovascularMultimodal ImagingPhantoms, ImagingPositron-Emission TomographyReproducibility of ResultsSensitivity and SpecificityConceptsSimultaneous PET-MRChannelized Hotelling observerAttenuation mapMotion correctionPET-MRFluorodeoxyglucose-positron emission tomography imagingRespiratory motion fieldsMotion correction methodCho SNRMotion correction techniqueAnthropomorphic phantomUncorrected reconstructionsRespiratory motionXCAT phantomCoronary plaque imagingMonte Carlo simulationsPET reconstructionXCATActivity distributionCardiac gatingNon-rigid registrationHotelling observerCarlo simulationsPlaque imagingPhantom
2009
Quantitative relationship between coronary calcium content and coronary flow reserve as assessed by integrated PET/CT imaging
Curillova Z, Yaman B, Dorbala S, Kwong R, Sitek A, El Fakhri G, Anagnostopoulos C, Di Carli M. Quantitative relationship between coronary calcium content and coronary flow reserve as assessed by integrated PET/CT imaging. European Journal Of Nuclear Medicine And Molecular Imaging 2009, 36: 1603-1610. PMID: 19387640, PMCID: PMC3117296, DOI: 10.1007/s00259-009-1121-1.Peer-Reviewed Original ResearchConceptsCoronary artery calcium scoreCoronary artery calciumCoronary vasodilator functionCoronary flow reserveCoronary artery diseaseHyperemic myocardial blood flowMyocardial blood flowVasodilator functionWeak inverse correlationCAC scoreCoronary artery calcium contentFlow reserveIncreasing CAC scorePer-vessel basisPer-patient basisInverse correlationBody mass indexCoronary calcium contentCoronary risk factorsCoronary vascular resistancePET/CT imagingConclusionIn patientsArtery calciumVascular resistanceMass index
2008
Quantitative relationship between coronary vasodilator reserve assessed by 82Rb PET imaging and coronary artery stenosis severity
Anagnostopoulos C, Almonacid A, El Fakhri G, Curillova Z, Sitek A, Roughton M, Dorbala S, Popma J, Di Carli M. Quantitative relationship between coronary vasodilator reserve assessed by 82Rb PET imaging and coronary artery stenosis severity. European Journal Of Nuclear Medicine And Molecular Imaging 2008, 35: 1593-1601. PMID: 18425513, PMCID: PMC3124702, DOI: 10.1007/s00259-008-0793-2.Peer-Reviewed Original ResearchConceptsPositron emission tomographyCoronary artery diseaseCoronary vasodilator reserveMyocardial blood flowPositron emission tomography imagingPercent diameter stenosisDiameter stenosisEmission tomographyAge-matchedStenosis severityHyperaemic myocardial blood flowRisk factorsStress myocardial blood flowVasodilator reserveFunctional assessment of coronary artery diseaseAssessment of coronary artery diseaseClinically useful tool