2024
Flat Panel TOF-PET Detectors: a Simulation Study
Orehar M, Dolenec R, Fakhri G, Gascón D, Gola A, Korpar S, Križan P, Razdevšek G, Marin T, Chemli Y, Žontar D, Pestotnik R. Flat Panel TOF-PET Detectors: a Simulation Study. 2024, 00: 1-2. DOI: 10.1109/nss/mic/rtsd57108.2024.10658250.Peer-Reviewed Original ResearchTime resolutionAngular coverageFlat-panel detectorScintillation materialsGATE softwareAxial coverageBiograph VisionPanel detectorTotal-body coverageClinical scannerImage reconstructionDetectorReconstructed imagesHomogeneous contrastCylindrical scannerImage qualityState-of-the-artScintillationHigh-performance computingScannerPhantomResolutionCore hoursPositron emission tomographyGate
2023
Next generation PET imager
Pestotnik R, Gascón D, Gola A, Benlloch J, Alamo J, Barberá J, Dolenec R, Fernández-Tenllado J, Gómez S, Grogg K, Guberman D, Korpar S, Križan P, Majewski S, Manera R, Marin T, Mariscal-Castilla A, Mauricio J, Merzi S, Morera C, Orehar M, Pavon G, Penna M, Razdevšek G, Seljak A, Studen A, Fakhri G. Next generation PET imager. 2023, 00: 1-1. DOI: 10.1109/nssmicrtsd49126.2023.10338336.Peer-Reviewed Original ResearchPET imaging systemsReadout electronicsTime resolutionDetected scintillation photonsDual-sided readoutFast readout electronicsTime-of-flight measurementsLYSO crystal arrayFast-timing applicationsFlat-panel detectorTotal-body PET imagingScintillation photonsPET detectorsSilicon photomultipliersScintillation materialsXCAT phantomPET systemPanel detectorPhoto sensorCrystal arrayImaging systemTime spreadTiming precisionScintillationSignal-to-noise ratio
2022
Simulation study of a 50 ps panel TOF PET imager
Pestotnik R, Razdevšek G, Dolenec R, Fakhri G, Križan P, Majewski S, Studen A, Korpar S. Simulation study of a 50 ps panel TOF PET imager. Journal Of Instrumentation 2022, 17: c12010. DOI: 10.1088/1748-0221/17/12/c12010.Peer-Reviewed Original ResearchPET scannerGamma detectorGamma raysTime-of-flight positron emission tomographyState-of-the-art clinical PET scannersGamma detection efficiencyClinical PET scannerImaging large objectsImproved time resolutionArtifact-free imagesDifferent phantomsDetector arrangementTime-of-flightBiograph VisionImage quality parametersDetection efficiencyTiming accuracyTime resolutionDetectorFWHMPositron emission tomographyReconstructed imagesRaysPositron emission tomography imagingMultichannel system
2021
Multipanel Limited Angle PET System With 50 ps FWHM Coincidence Time Resolution: A Simulation Study
Razdevšek G, Dolenec R, Križan P, Majewski S, Studen A, Korpar S, Fakhri G, Pestotnik R. Multipanel Limited Angle PET System With 50 ps FWHM Coincidence Time Resolution: A Simulation Study. IEEE Transactions On Radiation And Plasma Medical Sciences 2021, 6: 721-730. DOI: 10.1109/trpms.2021.3115704.Peer-Reviewed Original ResearchPET systemFWHM coincidence timing resolutionCoincidence time resolutionLutetium oxyorthosilicate crystalsExtended cardiac-torsoFlat-panel detectorClinical PET/CT scannerSpatial resolutionDerenzo phantomPlanar detectorsCount rateScanner geometryCardiac-torsoHot-rodDetection efficiencyParallax errorLow detection efficiencyIncreasing crystal lengthPET/CT scannerTime resolutionImage qualityScanner designAngular coverageFWHMCrystal lengthA layered single-side readout depth of interaction time-of-flight-PET detector
Bläckberg L, Sajedi S, Fakhri G, Sabet H. A layered single-side readout depth of interaction time-of-flight-PET detector. Physics In Medicine And Biology 2021, 66: 045025. PMID: 33570050, PMCID: PMC8130834, DOI: 10.1088/1361-6560/abd592.Peer-Reviewed Original ResearchConceptsDepth of interactionMulti-pixel photon counterDepth-of-interaction determinationDepth-of-interaction informationTime resolutionTime resolution valuesReduced crystal thicknessNon-DOI detectorsOptical photonsScintillator arrayPET detectorsPhoton counterCrystal pixelsReadout schemeCrystal arrayCrystal thicknessTransport simulationsDetectorPhotodetector arrayReadoutPixel sizePhotodetectorsResolution valuesFirst layerSignal amplitude
2020
Limited-angle TOF-PET for intraoperative surgical applications: latest results
Sajedi S, Bläckberg L, Fakhri G, Sabet H. Limited-angle TOF-PET for intraoperative surgical applications: latest results. 2020, 00: 1-3. DOI: 10.1109/nss/mic42677.2020.9507853.Peer-Reviewed Original ResearchCoincidence time resolutionWater phantomTOF-PETSphere-to-background activity ratiosLesion phantomsPET detector moduleDepth of interactionPET detector technologySmall-area detectorsDiameter spheresTime-of-flight (TOFPhantom depthDetector modulesCrystal pixelsDetector technologyDetector headFlight (TOFTime resolutionPhantomReduce FNRDetectorConventional gammaLarger-areaPixel dimensionsAngle geometryHigh Sensitivity and High Resolution Dynamic Brain-Dedicated TOF-DOI PET Scanner
Bläckberg L, Sanchez D, Borghi G, Ballabriga R, Sajedi S, Gómez S, Fakhri G, Mazzi A, Paternoster G, Majewski S, Gola A, Gascón D, Sabet H. High Sensitivity and High Resolution Dynamic Brain-Dedicated TOF-DOI PET Scanner. 2020, 00: 1-5. DOI: 10.1109/nss/mic42677.2020.9507837.Peer-Reviewed Original ResearchCoincidence time resolutionField of viewFWHM coincidence timing resolutionTime resolutionIntrinsic detector resolutionLow noise ASICsLYSO scintillator arrayScintillator arraySiPM arrayDetector conceptLYSO crystalsDetector volumeDetector resolutionPET detectorsSiPM signalsReduce image blurringDOI positionsHigh PDEPET scannerTiming jitterSimultaneous high resolutionScanner designTransport simulationsDetectorIntegrated light sensors
2019
Limited-Angle TOF-PET for Intraoperative Surgical Application
Sajedi S, Bläckberg L, Vittum B, Devabhaktuni A, Nejad M, Fakhri G, Choi H, Sabet H. Limited-Angle TOF-PET for Intraoperative Surgical Application. 2019, 00: 1-4. DOI: 10.1109/nss/mic42101.2019.9059690.Peer-Reviewed Original ResearchSentinel lymph nodeHigh-resolution positron emission tomographyTOF-PETNear-infraredDetector ringDetector blockIncreasing acquisition timeTorso phantomHot spheresBottom detectorPositron emission tomographyTime resolutionDetectorIdentification of sentinel lymph nodesAcquisition timeSentinel lymph node identificationReconstructed imagesAccurate identification of sentinel lymph nodesActivity concentrationsWhole-body positron emission tomographyComplete tumor removalFalse negative rateImage slicesImprove patient recoveryPatient bedPerformance evaluation of the 5‐Ring GE Discovery MI PET/CT system using the national electrical manufacturers association NU 2‐2012 Standard
Pan T, Einstein S, Kappadath S, Grogg K, Gomez C, Alessio A, Hunter W, Fakhri G, Kinahan P, Mawlawi O. Performance evaluation of the 5‐Ring GE Discovery MI PET/CT system using the national electrical manufacturers association NU 2‐2012 Standard. Medical Physics 2019, 46: 3025-3033. PMID: 31069816, PMCID: PMC7251507, DOI: 10.1002/mp.13576.Peer-Reviewed Original ResearchConceptsAxial field-of-viewPeak noise-equivalent count rateNoise-equivalent count rateField of viewCount ratePET performanceNational Electrical Manufacturers Association NU-2Transaxial field of viewPET/CT systemTime resolutionMean energy resolutionConventional photomultiplier tubesCount rate performanceImage quality phantomSpatial resolution measurementsFiltered back projection algorithmImage qualityEnergy resolutionAcquisition timeNU 2Count lossDetector designPhotomultiplier tubeMean energyPET/MR systemsFirst results developing time-of-flight proton radiography for proton therapy applications
Worstell W, Adams B, Aviles M, Bond J, Cascio E, Cremer T, Fakhri G, Ertley C, Foley M, Grogg K, Hamel C, Lu H, Lyashenko A, Minot M, Paganetti H, Popecki M, Stochaj M. First results developing time-of-flight proton radiography for proton therapy applications. Progress In Biomedical Optics And Imaging 2019, 10948: 109480g-109480g-9. DOI: 10.1117/12.2511804.Peer-Reviewed Original ResearchSub-relativisticMicro-channel plate photomultiplier tubeTime-of-flight telescopeTime resolutionProton therapy applicationsProton therapy treatmentsProton Therapy CenterResidual energy measurementProton beam testsBeam testMillimeter-scale spatial resolutionProton bunchesMonoenergetic protonsPlastic scintillatorPhoton detectorsProton radiographyImaging detectorMCP-PMTPhotomultiplier tubeBunch structureWaveform digitizerIndividual protonsMicrochannel plateHigh energyPhotodetection mode
2017
Simulation study of light transport in laser-processed LYSO:Ce detectors with single-side readout
Bläckberg L, Fakhri G, Sabet H. Simulation study of light transport in laser-processed LYSO:Ce detectors with single-side readout. Physics In Medicine And Biology 2017, 62: 8419-8440. PMID: 29047453, PMCID: PMC5736368, DOI: 10.1088/1361-6560/aa8dea.Peer-Reviewed Original ResearchConceptsDetector typesLYSO:Ce detectorsLYSO:Ce crystalsBarrier refractive indexScintillation light transportImproved energy resolutionRefractive indexLaser-processed crystalsCollection efficiencyLight transportPixel-like patternScintillation lightMPPC arraysEnergy resolutionPixel arrayDOI informationPulsed laser beamLight response functionLine profilesCe crystalsMonolithic crystalsBarrier patternsCrystal bulkTime resolutionCE detector