2022
Organomediated cleavage of benzoyl group enables an efficient synthesis of 1-(6-nitropyridin-2-yl)thiourea and its application for developing 18F-labeled PET tracers
Wang J, Takahashi K, Shoup T, Gong L, Li Y, El Fakhri G, Zhang Z, Brownell A. Organomediated cleavage of benzoyl group enables an efficient synthesis of 1-(6-nitropyridin-2-yl)thiourea and its application for developing 18F-labeled PET tracers. Bioorganic Chemistry 2022, 124: 105804. PMID: 35468416, PMCID: PMC9189786, DOI: 10.1016/j.bioorg.2022.105804.Peer-Reviewed Original Research
2020
Synthesis and Characterization of Fluorine-18-Labeled N‑(4-Chloro-3-((fluoromethyl‑d 2)thio)phenyl)picolinamide for Imaging of mGluR4 in Brain
Wang J, Qu X, Shoup T, Yuan G, Afshar S, Pan C, Zhu A, Choi J, Kang H, Poutiainen P, Fakhri G, Zhang Z, Brownell A. Synthesis and Characterization of Fluorine-18-Labeled N‑(4-Chloro-3-((fluoromethyl‑d 2)thio)phenyl)picolinamide for Imaging of mGluR4 in Brain. Journal Of Medicinal Chemistry 2020, 63: 3381-3389. PMID: 32081008, PMCID: PMC7261135, DOI: 10.1021/acs.jmedchem.0c00201.Peer-Reviewed Original ResearchConceptsDrug-like propertiesMethylthio analoguePotential ligandsMetabolic stabilityPositron emission tomographyRadiochemical yieldMolar activityDose-dependent blocking effectPositron emission tomography imaging studiesMethylthioPAM activityBrain regionsMale Sprague Dawley ratsLigandEx vivo biodistribution studiesRadiosynthesisSprague Dawley ratsBrainMGluR4SynthesisAnaloguesEmission tomographyImaging studies
2017
Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials
Yuan H, Wilks M, Fakhri G, Normandin M, Kaittanis C, Josephson L. Heat-induced-radiolabeling and click chemistry: A powerful combination for generating multifunctional nanomaterials. PLOS ONE 2017, 12: e0172722. PMID: 28225818, PMCID: PMC5321420, DOI: 10.1371/journal.pone.0172722.Peer-Reviewed Original ResearchConceptsClick reactionClick chemistryCopper-free click reactionCopper-catalyzedAzide groupsBiomolecule attachmentReporter groupNP surfaceTargeted nanoparticlesNanoparticlesBioactive groupsMultifunctional nanomaterialsBiomedical applicationsSynthesisIntermediateReactionChemistryNanomaterialsBiomoleculesAlkynesCombination of techniquesCell surface receptorsAzideTherapeutic agentsClick
2014
Synthesis of the dopamine D2/D3 receptor agonist (+)-PHNO via supercritical fluid chromatography: preliminary PET imaging study with [3-11C]-(+)PHNO
Shoup T, McCauley J, Lee D, Chen R, Normandin M, Bonab A, Fakhri G, Vasdev N. Synthesis of the dopamine D2/D3 receptor agonist (+)-PHNO via supercritical fluid chromatography: preliminary PET imaging study with [3-11C]-(+)PHNO. Tetrahedron Letters 2014, 55: 682-685. DOI: 10.1016/j.tetlet.2013.11.113.Peer-Reviewed Original ResearchPositron emission tomography imaging studiesSupercritical fluid chromatographyPositron emission tomographyFluid chromatographyImaging studiesAgonist radiopharmaceuticalsDopamine receptorsEnantiomeric resolutionDopamineCarbon-11Emission tomographyAdipose tissueBrown adipose tissueIn vivoBrown fatSynthesis