2023
Measurement of Cerebral Perfusion Indices from the Early Phase of [18F]MK6240 Dynamic Tau PET Imaging
Guehl N, Dhaynaut M, Hanseeuw B, Moon S, Lois C, Thibault E, Fu J, Price J, Johnson K, El Fakhri G, Normandin M. Measurement of Cerebral Perfusion Indices from the Early Phase of [18F]MK6240 Dynamic Tau PET Imaging. Journal Of Nuclear Medicine 2023, 64: 968-975. PMID: 36997330, PMCID: PMC10241011, DOI: 10.2967/jnumed.122.265072.Peer-Reviewed Original ResearchConceptsTime-activity curvesCerebral perfusionMetabolite-corrected arterial input functionBrain time-activity curvesEarly phaseRegional time-activity curvesIndices of cerebral perfusionDynamic [<sup>18</sup>FBlood-brain barrierPlasma to brain tissueStatistically significant differenceArterial blood samplesForty-nine subjectsCNArterial input functionPathophysiological mechanismsPerfusion indicatorsPET imagingBlood samplesSignificant differenceSurrogate indexNoninvasive estimationAnatomical informationCompound BForty-nine
2007
Validation of a Standardized Normalization Template for Statistical Parametric Mapping Analysis of 123I-FP-CIT Images
Kas A, Payoux P, Habert M, Malek Z, Cointepas Y, El Fakhri G, Chaumet-Riffaud P, Itti E, Remy P. Validation of a Standardized Normalization Template for Statistical Parametric Mapping Analysis of 123I-FP-CIT Images. Journal Of Nuclear Medicine 2007, 48: 1459-1467. PMID: 17704252, DOI: 10.2967/jnumed.106.038646.Peer-Reviewed Original ResearchConceptsStatistical parametric mappingDopamine transporterStatistical parametric mapping analysisIntraclass correlation coefficientStriatal (123)I-FP-CIT uptakeParkinson's diseaseStatistical parametric mapping approachEssential tremorBland-Altman graphical analysisStriatal volumeDopaminergic cell lossDAT imagingLow intraclass correlation coefficientsParametric mappingSpatial normalizationNo significant differencePD patientsCustomized templateIntergroup analysisCell lossSpatial normalization procedureResults of groupSPM normalizationSignificant differenceSPECT