2024
Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP
Zhou Y, Wilks M, Dhaynaut M, Guehl N, Vesper D, Moon S, Rice P, El Fakhri G, Normandin M, Brugarolas P. Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP. EJNMMI Research 2024, 14: 43. PMID: 38683467, PMCID: PMC11058135, DOI: 10.1186/s13550-024-01092-8.Peer-Reviewed Original ResearchRadiation dosimetryAverage effective doseWhole-body biodistributionTotal scan timeNon-decayEffective doseNon-human primatesSymptomatic treatment of multiple sclerosisIn vivo binding affinityBed positionTreatment of multiple sclerosisHigh-resolution CTDynamic acquisition protocolDosimetryPET dataAdult rhesus macaquesScan timeImaging demyelinationOLINDA softwareRadiationAcquisition protocolsPreclinical studiesNo significant changesHigh dosesPET imaging
2021
Deep learning-based GTV contouring modeling inter- and intra- observer variability in sarcomas
Marin T, Zhuo Y, Lahoud R, Tian F, Ma X, Xing F, Moteabbed M, Liu X, Grogg K, Shusharina N, Woo J, Lim R, Ma C, Chen Y, El Fakhri G. Deep learning-based GTV contouring modeling inter- and intra- observer variability in sarcomas. Radiotherapy And Oncology 2021, 167: 269-276. PMID: 34808228, PMCID: PMC8934266, DOI: 10.1016/j.radonc.2021.09.034.Peer-Reviewed Original ResearchConceptsGross tumor volumeRadiation therapy treatment planningGross tumor volume contoursGross tumor volume delineationTherapy treatment planningIntra-observer variabilityConsensus contoursGTV contoursPre-operative CT imagesSoft tissue sarcomasRadiation oncologistsTumor volumeBone sarcomasTreatment planningAccurate contoursCT imagesDelineation procedureSarcomaSoft tissueConfidence levelRadiationPatientsHausdorff distanceMultiple contoursX-ray
2016
ORAL02.03: Robust Correlation Between Metabolic Response Measured with 18F-FDG PET Soon After Therapy and Clinical Outcome in Lung Cancer Topic: Radiation Oncology
Choi N, Gainor J, Ackman J, Lim R, Sharp G, Fakhri G, Niemierko A. ORAL02.03: Robust Correlation Between Metabolic Response Measured with 18F-FDG PET Soon After Therapy and Clinical Outcome in Lung Cancer Topic: Radiation Oncology. Journal Of Thoracic Oncology 2016, 11: s253-s254. DOI: 10.1016/j.jtho.2016.09.012.Peer-Reviewed Original Research
2015
Improved Local Tumor Control With Supplementary Dose of Radiation Guided by 18F-FDG PET Soon After Standard Dose Radiation Therapy and Concurrent Chemotherapy in Inoperable Stages II and III Non-Small Cell Lung Cancer
Choi N, Gainor J, Ackman J, Lim R, Sharp G, Fakhri G, Niemierko A. Improved Local Tumor Control With Supplementary Dose of Radiation Guided by 18F-FDG PET Soon After Standard Dose Radiation Therapy and Concurrent Chemotherapy in Inoperable Stages II and III Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: e438-e439. DOI: 10.1016/j.ijrobp.2015.07.1664.Peer-Reviewed Original ResearchMonitoring proton therapy with PET
Paganetti H, Fakhri G. Monitoring proton therapy with PET. British Journal Of Radiology 2015, 88: 20150173. PMID: 25989699, PMCID: PMC4628541, DOI: 10.1259/bjr.20150173.Peer-Reviewed Original ResearchConceptsPatient set-upDose conformityDose shapingInterfractional changesProton beamBeam deliveryDose calculationProton therapyTumor coveragePhotonic techniquesTreatment volumeTotal energyPatient anatomyBeamRadiation therapyProtonPatientsTherapyReduced total energyDoseSet-upRangeCalculationsRadiationEnergy