2024
Deciphering the effects of radiopharmaceutical therapy in the tumor microenvironment of prostate cancer: an in-silico exploration with spatial transcriptomics
Hong J, Bae S, Cavinato L, Seifert R, Ryhiner M, Rominger A, Erlandsson K, Wilks M, Normandin M, El-Fakhri G, Choi H, Shi K. Deciphering the effects of radiopharmaceutical therapy in the tumor microenvironment of prostate cancer: an in-silico exploration with spatial transcriptomics. Theranostics 2024, 14: 7122-7139. DOI: 10.7150/thno.99516.Peer-Reviewed Original Research
2017
PSMA-targeted contrast agents for intraoperative imaging of prostate cancer ,
Bao K, Lee J, Kang H, Park G, Fakhri G, Choi H. PSMA-targeted contrast agents for intraoperative imaging of prostate cancer ,. Chemical Communications 2017, 53: 1611-1614. PMID: 28085163, PMCID: PMC5728657, DOI: 10.1039/c6cc09781b.Peer-Reviewed Original Research
2015
Stochastic simulation of radium-223 dichloride therapy at the sub-cellular level
Gholami Y, Zhu X, Fulton R, Meikle S, El-Fakhri G, Kuncic Z. Stochastic simulation of radium-223 dichloride therapy at the sub-cellular level. Physics In Medicine And Biology 2015, 60: 6087-6096. PMID: 26216391, DOI: 10.1088/0031-9155/60/15/6087.Peer-Reviewed Original ResearchConceptsEstimate radiation damageAlpha particle tracksAlpha-particle emittersMonte Carlo modelIonization clustersDose depositionAlpha particlesAlpha emissionParticle therapyAlpha-particle therapyEnergy depositionRadiation damageCarlo modelEfficacy of cell killingParticle emittersRadium-223 dichlorideBone-seeking radionuclidesParticle trackingRadium-223Prostate cancerAverage doseCell nucleiCell killingIndirect DNA damageNucleus