Higher circulating cortisol is associated with amyloidogenesis in post‐menopausal women: The Framingham Heart Study
Salardini A, Zilli E, Himali J, Gonzales M, Himali D, Ghosh S, McGrath E, Buckley R, Satizabal C, Johnson K, Decarli C, Fakhri G, Vasan R, Seshadri S. Higher circulating cortisol is associated with amyloidogenesis in post‐menopausal women: The Framingham Heart Study. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.080594.Peer-Reviewed Original ResearchFramingham Heart StudyHeart StudyProspective cohort studyCross sectional studyPostmenopausal womenCognitively normal individualsPost-menopausal womenSectional studyAPOE4 statusAPOE4-positiveLongitudinal cohortSuperior temporal sulcusCortisol levelsMenopausal statusSecondary outcomesAlzheimer's diseaseAssociated with amyloidogenesisCortisol dysregulationBaseline plasma cortisolMorning plasma cortisolTertileFraminghamWomenAssess interactionsProgression of Alzheimer's diseaseTau-PET abnormality as a biomarker for Alzheimer’s disease staging and early detection: a topological perspective
Ding J, Shen C, Wang Z, Yang Y, Fakhri G, Lu J, Liang D, Zheng H, Zhou Y, Sun T, Study F. Tau-PET abnormality as a biomarker for Alzheimer’s disease staging and early detection: a topological perspective. Cerebral Cortex 2023, 33: 10649-10659. PMID: 37653600, DOI: 10.1093/cercor/bhad312.Peer-Reviewed Original ResearchConceptsStandardized uptake value ratioMild cognitive impairmentBrain regionsCognitive impairmentPositron emission tomographyMedial temporal lobeAlzheimer's diseaseVisual-related regionsTopological perspectiveTau positron emission tomographyMode networkTau PET imagingTopological featuresIndependent data cohortsTemporal lobeConnection strengthExtract topological featuresTau networksAbnormal networkProgression of Alzheimer's diseaseAbnormal protein accumulation