2017
Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex
Sepulcre J, Grothe M, Sabuncu M, Chhatwal J, Schultz A, Hanseeuw B, Fakhri G, Sperling R, Johnson K. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. JAMA Neurology 2017, 74: 813-820. PMID: 28558094, PMCID: PMC5710537, DOI: 10.1001/jamaneurol.2017.0263.Peer-Reviewed Original ResearchConceptsHeteromodal areasTemporal lobeHarvard Aging Brain StudyHeteromodal association regionsAging Brain StudyCognitively normal participantsElderly brainsPositron emission tomographicPrimary somatomotor cortexDistribution volume ratioAlzheimer's diseaseTau depositionStandardized uptake value ratioVisual regionsNormal participantsAb depositionSomatomotor cortexTemporal areaPittsburgh compound BCarbon 11-labeled Pittsburgh Compound BBrain studiesAssociation regionsHuman brainPathological hallmarks of Alzheimer's diseaseCortical distribution
2014
First Human Use of a Radiopharmaceutical Prepared by Continuous-Flow Microfluidic Radiofluorination: Proof of Concept with the Tau Imaging Agent [18F]T807
Liang S, Yokell D, Normandin M, Rice P, Jackson R, Shoup T, Brady T, Fakhri G, Collier T, Vasdev N. First Human Use of a Radiopharmaceutical Prepared by Continuous-Flow Microfluidic Radiofluorination: Proof of Concept with the Tau Imaging Agent [18F]T807. Molecular Imaging 2014, 13: 7290.2014.00025. PMID: 25248283, DOI: 10.2310/7290.2014.00025.Peer-Reviewed Original Research
2006
Quantitative Analysis of PET Reconstruction Techniques over a Wide Activity Range with 2D and 3D Acquisition Modes
Wollenweber S, Fakhri G, Moore S. Quantitative Analysis of PET Reconstruction Techniques over a Wide Activity Range with 2D and 3D Acquisition Modes. 2006, 4: 2233-2235. DOI: 10.1109/nssmic.2006.354358.Peer-Reviewed Original ResearchPositron emission tomographicField of viewFiltered backprojectionEstimation of activity concentrationImaging field of viewQuantitative imaging performanceIterative reconstruction methodValues of activity concentrationsActivity concentrationsPET-CT systemFBP imagesScan modeReconstruction methodROI valuesImaging performanceAnalytical reconstructionEmission tomographicRegions-of-interestROI activityPET-CTPhantomOSEMF-18BackprojectionTissue background