2021
Evaluation of Fluorinated Cromolyn Derivatives as Potential Therapeutics for Alzheimer’s Disease
Shoup T, Griciuc A, Normandin M, Quinti L, Walsh L, Dhaynaut M, Moon S, Guehl N, Brugarolas P, Elmaleh D, Fakhri G, Tanzi R. Evaluation of Fluorinated Cromolyn Derivatives as Potential Therapeutics for Alzheimer’s Disease. Journal Of Alzheimer's Disease 2021, 80: 775-786. PMID: 33579853, DOI: 10.3233/jad-201419.Peer-Reviewed Original ResearchConceptsMicroglial cellsCell toxicityPET imagingMultifactorial mechanism of actionBV2 microglial cellsDose-dependent mannerBV2 microglial cell lineMicroglial cell lineMechanism of actionF-18Multifactorial mechanismsPro-inflammatoryHigher perfusionLow perfusionRhesus macaquesCromolynCell linesIncreased uptakeTracer penetrationEnhanced uptakePotential therapeuticsPerfusionToxicityClearance assayClearance
2005
Quantitative dynamic cardiac 82Rb PET using generalized factor and compartment analyses.
El Fakhri G, Sitek A, Guérin B, Kijewski M, Di Carli M, Moore S. Quantitative dynamic cardiac 82Rb PET using generalized factor and compartment analyses. Journal Of Nuclear Medicine 2005, 46: 1264-71. PMID: 16085581.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlgorithmsComputer SimulationCoronary Artery DiseaseFeasibility StudiesFemaleHeartHumansImage Interpretation, Computer-AssistedMaleMiddle AgedModels, CardiovascularPositron-Emission TomographyRadiopharmaceuticalsReproducibility of ResultsRubidium RadioisotopesSensitivity and SpecificitySeverity of Illness IndexConceptsMyocardial perfusionAbsolute myocardial perfusionCatheterization resultsMyocardial tissue extractsDipyridamole stressCardiac PETClinical valueMyocardial factorsFactor analysis of dynamic sequencesPatient studiesLVNoninvasive estimationAccurate input functionPatientsCompartment analysisAverage errorPerfusionParametric mappingTissue extractsRV contributionRV