2011
Impact of Time-of-Flight PET on Whole-Body Oncologic Studies: A Human Observer Lesion Detection and Localization Study
Surti S, Scheuermann J, Fakhri G, Daube-Witherspoon M, Lim R, Abi-Hatem N, Moussallem E, Benard F, Mankoff D, Karp J. Impact of Time-of-Flight PET on Whole-Body Oncologic Studies: A Human Observer Lesion Detection and Localization Study. Journal Of Nuclear Medicine 2011, 52: 712-719. PMID: 21498523, PMCID: PMC3104282, DOI: 10.2967/jnumed.110.086678.Peer-Reviewed Original ResearchConceptsLocalization receiver operating characteristicsTime-of-flight PETLong scan timesArea under the LROC curveScan timeFunction of scan timePatient sizeTime-of-flight (TOFLROC curveLow-uptake lesionsTOF imagesTOF kernelLesion detection taskTOF-PETWhole-body oncologyLesion detection performanceScanner fieldPhantom studyPatient body mass indexProbability of correct localizationLesion detectionSphere dataBody mass indexLarger patientsReceiver operating characteristic
2007
Impact of Acquisition Geometry, Image Processing, and Patient Size on Lesion Detection in Whole-Body 18F-FDG PET
Fakhri G, Santos P, Badawi R, Holdsworth C, Van Den Abbeele A, Kijewski M. Impact of Acquisition Geometry, Image Processing, and Patient Size on Lesion Detection in Whole-Body 18F-FDG PET. Journal Of Nuclear Medicine 2007, 48: 1951-1960. PMID: 18006613, DOI: 10.2967/jnumed.108.007369.Peer-Reviewed Original ResearchConceptsAttenuation-weighted OSEMOrdered-subset expectation maximizationNoise equivalent countPhantom sizeBed positionCho SNRPatient sizeFourier rebinningAttenuation mapPET scannerLesion detectionMarginal detectionTransmission scanWhole-body (18)F-FDG PETAttenuation correctionWhole-body 18F-FDG PETHotelling observerScaling 2DSinogramReconstructed volumeDetection SNRPhantomSystematic improvementFBPScattering
2003
Evaluation of a Monte Carlo Scatter Correction in Clinical 3D PET
Holdsworth C, Badawi R, Santos P, Van den Abbeele A, Hoffman E, Fakhri G. Evaluation of a Monte Carlo Scatter Correction in Clinical 3D PET. 2003, 4: 2540-2544. DOI: 10.1109/nssmic.2003.1352408.Peer-Reviewed Original ResearchScatter correctionUncorrected imagesPET imagingChannelized Hotelling observerHotelling observerPatient dataPatient imagesQuantitative accuracyLesion detection sensitivityPatient sizePhantomLesion sensitivityPatientsMonteLesionsLesion detectionCorrectionROI analysisIntensity varianceDetection sensitivityPETScatteringAverage absolute bias
2002
Impact of Acquisition Geometry and Patient Habitus on Lesion Detectability in Whole-Body FDG-PET: A Channelized Hotelling Observer Study
Fakhri G, Holdsworth C, Badawi R, Santos P, Moore S, Van den Abbeele A, Kijewski M. Impact of Acquisition Geometry and Patient Habitus on Lesion Detectability in Whole-Body FDG-PET: A Channelized Hotelling Observer Study. 2002, 3: 1402-1405. DOI: 10.1109/nssmic.2002.1239583.Peer-Reviewed Original ResearchBed positionChannelized Hotelling observer studyFDG-PET studiesAttenuation mapAcquisition modeMarginal detectionFDG-PETLesion detectionWhole-body FDG-PETHotelling observerScaling 2DTypical sizePatient sizeHours post-injectionPatient habitusAnatomical backgroundWhole bodyLesion sizeObservational studyPatientsLesionsLesion siteModePost-injectionAcquisition geometry