2015
Stochastic simulation of radium-223 dichloride therapy at the sub-cellular level
Gholami Y, Zhu X, Fulton R, Meikle S, El-Fakhri G, Kuncic Z. Stochastic simulation of radium-223 dichloride therapy at the sub-cellular level. Physics In Medicine And Biology 2015, 60: 6087-6096. PMID: 26216391, DOI: 10.1088/0031-9155/60/15/6087.Peer-Reviewed Original ResearchConceptsEstimate radiation damageAlpha particle tracksAlpha-particle emittersMonte Carlo modelIonization clustersDose depositionAlpha particlesAlpha emissionParticle therapyAlpha-particle therapyEnergy depositionRadiation damageCarlo modelEfficacy of cell killingParticle emittersRadium-223 dichlorideBone-seeking radionuclidesParticle trackingRadium-223Prostate cancerAverage doseCell nucleiCell killingIndirect DNA damageNucleus
2009
Monte Carlo modeling of cascade gamma rays in 86Y PET imaging: preliminary results
Zhu X, Fakhri G. Monte Carlo modeling of cascade gamma rays in 86Y PET imaging: preliminary results. Physics In Medicine And Biology 2009, 54: 4181-4193. PMID: 19521011, PMCID: PMC3111055, DOI: 10.1088/0031-9155/54/13/014.Peer-Reviewed Original ResearchConceptsCascade gamma raysScatter fractionGamma raysPhoton energy distributionLow count ratesHigh-energy photonsMonte Carlo programScatter correction methodGATE simulation packageMonte Carlo modelDevelopment of correction methodsSpatial resolutionGamma photonsEnergy windowCount rateScattering eventsRandom coincidencesEnergy distributionPhantom acquisitionsPersonal dosimetryPET imagingVariance reduction techniquesPhotonsCorrection methodSimSET
2006
Monte Carlo Modeling of Cascade Gamma Rays in PET
Zhu X, Fakhri G. Monte Carlo Modeling of Cascade Gamma Rays in PET. 2011 IEEE Nuclear Science Symposium Conference Record 2006, 6: 3522-3525. DOI: 10.1109/nssmic.2006.353759.Peer-Reviewed Original ResearchCascade gamma raysGamma raysGamma-ray emitting isotopesDetector dead timeMonte Carlo modelPET imagingGamma eventsScatter fractionQuantitative PET imagingTorso phantomSingles ratesMonte Carlo simulationsDecrease of intensityHigh-activity regionsPhantom experimentsReconstructed volumePhantomRaysCarlo simulationsDead timeDetectorReconstructed imagesCascade typeImage intensityMonte