2021
Evaluation of Fluorinated Cromolyn Derivatives as Potential Therapeutics for Alzheimer’s Disease
Shoup T, Griciuc A, Normandin M, Quinti L, Walsh L, Dhaynaut M, Moon S, Guehl N, Brugarolas P, Elmaleh D, Fakhri G, Tanzi R. Evaluation of Fluorinated Cromolyn Derivatives as Potential Therapeutics for Alzheimer’s Disease. Journal Of Alzheimer's Disease 2021, 80: 775-786. PMID: 33579853, DOI: 10.3233/jad-201419.Peer-Reviewed Original ResearchConceptsMicroglial cellsCell toxicityPET imagingMultifactorial mechanism of actionBV2 microglial cellsDose-dependent mannerBV2 microglial cell lineMicroglial cell lineMechanism of actionF-18Multifactorial mechanismsPro-inflammatoryHigher perfusionLow perfusionRhesus macaquesCromolynCell linesIncreased uptakeTracer penetrationEnhanced uptakePotential therapeuticsPerfusionToxicityClearance assayClearance
2006
Quantitative Analysis of PET Reconstruction Techniques over a Wide Activity Range with 2D and 3D Acquisition Modes
Wollenweber S, Fakhri G, Moore S. Quantitative Analysis of PET Reconstruction Techniques over a Wide Activity Range with 2D and 3D Acquisition Modes. 2006, 4: 2233-2235. DOI: 10.1109/nssmic.2006.354358.Peer-Reviewed Original ResearchPositron emission tomographicField of viewFiltered backprojectionEstimation of activity concentrationImaging field of viewQuantitative imaging performanceIterative reconstruction methodValues of activity concentrationsActivity concentrationsPET-CT systemFBP imagesScan modeReconstruction methodROI valuesImaging performanceAnalytical reconstructionEmission tomographicRegions-of-interestROI activityPET-CTPhantomOSEMF-18BackprojectionTissue background
2000
Relative lesion detectability in 3D vs. 2D dedicated multi-ring PET
Moore S, Fakhri G, Badawi R, Van den Abbeele A, Zimmerman R. Relative lesion detectability in 3D vs. 2D dedicated multi-ring PET. 2011 IEEE Nuclear Science Symposium Conference Record 2000, 3: 17/18-17/22 vol.3. DOI: 10.1109/nssmic.2000.949192.Peer-Reviewed Original ResearchField of viewNon-prewhiteningAxial field-of-viewMaximum ring differenceAnthropomorphic torso phantomClinically realistic phantomDetection of spheresNPW-SNRTorso phantomGe-68Head phantomDetection signal-to-noise ratioRing differenceRealistic phantomsPhantomBed positionF-18Signal-to-noise ratioActivity concentrationsTwo-dimensionalContrast levelsPET imagingCompare two-dimensionalModeFORE+FBP