2022
Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Burden in Patients with Alzheimer’s Disease: A Case Series1
Dhaynaut M, Sprugnoli G, Cappon D, Macone J, Sanchez J, Normandin M, Guehl N, Koch G, Paciorek R, Connor A, Press D, Johnson K, Pascual-Leone A, Fakhri G, Santarnecchi E. Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Burden in Patients with Alzheimer’s Disease: A Case Series1. Journal Of Alzheimer's Disease 2022, 85: 1667-1676. PMID: 34958021, PMCID: PMC9023125, DOI: 10.3233/jad-215072.Peer-Reviewed Original ResearchConceptsMicroglia activationGamma spectral powerDecrease of microglia activationNo adverse eventsTranscranial alternating current stimulationSlow disease progressionPlacebo-controlled conditionsPreclinical dataCase seriesAdverse eventsGamma oscillationsElectrophysiological assessmentP-tauMouse modelDisease progressionMesial regionMild to moderate ADAnimal modelsPatientsPET imagingAlzheimer's diseaseSpectral powerAD mouse modelAD patientsProtein clearance
2019
Fluorometric Imaging for Early Diagnosis and Prognosis of Rheumatoid Arthritis
Lee J, Jung S, Park G, Bao K, Hyun H, Fakhri G, Choi H. Fluorometric Imaging for Early Diagnosis and Prognosis of Rheumatoid Arthritis. Advanced Science 2019, 7: 1902267. PMID: 31921569, PMCID: PMC6947695, DOI: 10.1002/advs.201902267.Peer-Reviewed Original ResearchRheumatoid arthritisDisease progressionEarly diagnosisFluorometric imagingMouse model of RAPrognosis of rheumatoid arthritisTreatment of rheumatoid arthritisTissue-specific contrast agentsEffective treatment of rheumatoid arthritisModel of RAMonitoring of disease progressionTreatment of RACourse of RAImaging of RAIrreversible joint damagePrognosis of RASystemic treatmentSystemic complicationsContinuous inflammationProgressive courseMonitoring structural damageBone resorptionMouse modelPrognosis of diseaseEffective treatment