2020
Non-Invasive Photoacoustic Imaging of In Vivo Mice with Erythrocyte Derived Optical Nanoparticles to Detect CAD/MI
Liu Y, Hanley T, Chen H, Long S, Gambhir S, Cheng Z, Wu J, Fakhri G, Anvari B, Zaman R. Non-Invasive Photoacoustic Imaging of In Vivo Mice with Erythrocyte Derived Optical Nanoparticles to Detect CAD/MI. Scientific Reports 2020, 10: 5983. PMID: 32249814, PMCID: PMC7136251, DOI: 10.1038/s41598-020-62868-1.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseMyocardial-infarctionTail vein 1 hourIndocyanine greenWeeks old male C57BL/6 miceLeft anterior descending (LADAnterior descending (LADMale C57BL/6 miceAtherosclerotic lesionsCoronary artery ligationTen-week-old male C57BL/6 miceAtherosclerotic plaquesC57BL/6 miceNon-invasiveArtery ligationInflammatory cellsPortal tractsArtery diseaseFluorescence in vivo imagingParenchymal necrosisCoronary arteryClinical detectionPathological changesContrast agentsLesions
2010
WE‐D‐201B‐03: Recent Advances in PET Quantitation of Myocardial Blood Flow
Fakhri G. WE‐D‐201B‐03: Recent Advances in PET Quantitation of Myocardial Blood Flow. Medical Physics 2010, 37: 3433-3433. DOI: 10.1118/1.3469414.Peer-Reviewed Original Research
2009
Quantitative relationship between coronary calcium content and coronary flow reserve as assessed by integrated PET/CT imaging
Curillova Z, Yaman B, Dorbala S, Kwong R, Sitek A, El Fakhri G, Anagnostopoulos C, Di Carli M. Quantitative relationship between coronary calcium content and coronary flow reserve as assessed by integrated PET/CT imaging. European Journal Of Nuclear Medicine And Molecular Imaging 2009, 36: 1603-1610. PMID: 19387640, PMCID: PMC3117296, DOI: 10.1007/s00259-009-1121-1.Peer-Reviewed Original ResearchConceptsCoronary artery calcium scoreCoronary artery calciumCoronary vasodilator functionCoronary flow reserveCoronary artery diseaseHyperemic myocardial blood flowMyocardial blood flowVasodilator functionWeak inverse correlationCAC scoreCoronary artery calcium contentFlow reserveIncreasing CAC scorePer-vessel basisPer-patient basisInverse correlationBody mass indexCoronary calcium contentCoronary risk factorsCoronary vascular resistancePET/CT imagingConclusionIn patientsArtery calciumVascular resistanceMass index
2008
Quantitative relationship between coronary vasodilator reserve assessed by 82Rb PET imaging and coronary artery stenosis severity
Anagnostopoulos C, Almonacid A, El Fakhri G, Curillova Z, Sitek A, Roughton M, Dorbala S, Popma J, Di Carli M. Quantitative relationship between coronary vasodilator reserve assessed by 82Rb PET imaging and coronary artery stenosis severity. European Journal Of Nuclear Medicine And Molecular Imaging 2008, 35: 1593-1601. PMID: 18425513, PMCID: PMC3124702, DOI: 10.1007/s00259-008-0793-2.Peer-Reviewed Original ResearchConceptsPositron emission tomographyCoronary artery diseaseCoronary vasodilator reserveMyocardial blood flowPositron emission tomography imagingPercent diameter stenosisDiameter stenosisEmission tomographyAge-matchedStenosis severityHyperaemic myocardial blood flowRisk factorsStress myocardial blood flowVasodilator reserveFunctional assessment of coronary artery diseaseAssessment of coronary artery diseaseClinically useful tool
2007
Clinical Myocardial Perfusion PET/CT
Di Carli M, Dorbala S, Meserve J, Fakhri G, Sitek A, Moore S. Clinical Myocardial Perfusion PET/CT. Journal Of Nuclear Medicine 2007, 48: 783-793. PMID: 17475968, DOI: 10.2967/jnumed.106.032789.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseMyocardial perfusion PETPerfusion PETDiagnosing obstructive CADClinically useful risk stratificationObstructive coronary artery diseaseAnatomic coronary artery diseaseMyocardial perfusion PET/CTMultivessel coronary artery diseaseLeft ventricular functionEvaluation of patientsQuantify myocardial perfusionVentricular functionIschemic burdenPharmacological stressRisk stratificationCardiac PETArtery diseasePET/CT technologyMyocardial perfusionAttenuation correctionNuclear cardiologyFunctional consequencesSPECTPET