2020
Non-Invasive Photoacoustic Imaging of In Vivo Mice with Erythrocyte Derived Optical Nanoparticles to Detect CAD/MI
Liu Y, Hanley T, Chen H, Long S, Gambhir S, Cheng Z, Wu J, Fakhri G, Anvari B, Zaman R. Non-Invasive Photoacoustic Imaging of In Vivo Mice with Erythrocyte Derived Optical Nanoparticles to Detect CAD/MI. Scientific Reports 2020, 10: 5983. PMID: 32249814, PMCID: PMC7136251, DOI: 10.1038/s41598-020-62868-1.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseMyocardial-infarctionTail vein 1 hourIndocyanine greenWeeks old male C57BL/6 miceLeft anterior descending (LADAnterior descending (LADMale C57BL/6 miceAtherosclerotic lesionsCoronary artery ligationTen-week-old male C57BL/6 miceAtherosclerotic plaquesC57BL/6 miceNon-invasiveArtery ligationInflammatory cellsPortal tractsArtery diseaseFluorescence in vivo imagingParenchymal necrosisCoronary arteryClinical detectionPathological changesContrast agentsLesionsA Radio-Nano-Platform for T1/T2 Dual-Mode PET-MR Imaging
Gholami Y, Yuan H, Wilks M, Maschmeyer R, Normandin M, Josephson L, Fakhri G, Kuncic Z. A Radio-Nano-Platform for T1/T2 Dual-Mode PET-MR Imaging. International Journal Of Nanomedicine 2020, 15: 1253-1266. PMID: 32161456, PMCID: PMC7049573, DOI: 10.2147/ijn.s241971.Peer-Reviewed Original ResearchConceptsLine spread functionPET-MR imagingSignal-to-noise ratioFull-width half-maximum (FWHMPET-MRHalf-maximum (FWHMSpatial resolutionTransmission electron microscopyImage quality gainSimultaneous positron emission tomographyContrast-enhanced diagnostic imagingAtom adsorptionPhantom imagesPositron emission tomographySpatial resolution of MRHybrid PET-MRRadio-isotopesSpread functionMulti-modal imaging techniquesSensitivity of positron emission tomographyMagnetic resonanceCo-registeredTransmission electron microscopy analysisSuper paramagnetic iron oxide nanoparticlesContrast agents
2017
PSMA-targeted contrast agents for intraoperative imaging of prostate cancer ,
Bao K, Lee J, Kang H, Park G, Fakhri G, Choi H. PSMA-targeted contrast agents for intraoperative imaging of prostate cancer ,. Chemical Communications 2017, 53: 1611-1614. PMID: 28085163, PMCID: PMC5728657, DOI: 10.1039/c6cc09781b.Peer-Reviewed Original Research
2016
Tissue-Specific Near-Infrared Fluorescence Imaging
Owens E, Henary M, Fakhri G, Choi H. Tissue-Specific Near-Infrared Fluorescence Imaging. Accounts Of Chemical Research 2016, 49: 1731-1740. PMID: 27564418, PMCID: PMC5776714, DOI: 10.1021/acs.accounts.6b00239.Peer-Reviewed Original ResearchConceptsSingle-photon emission computed tomographyPositron emission tomographyVital tissuesReal-time intraoperative navigationReal-time image guidanceContrast agentsTargeted NIR fluorophoresEmission computed tomographyTissue-specific contrast agentsEffective imaging agentsTissue-specific targetingReal-time delineationIntraoperative successTargeted therapyImage guidanceTumor tissuesEPR effectIntraoperative navigationSurgical fieldClinical imaging technologyDiagnostic utilityClinical useEmission tomographySurgical spaceTarget tissues