2022
Cardiac PET/MR Basics
Petibon Y, Ma C, Ouyang J, El Fakhri G. Cardiac PET/MR Basics. 2022, 21-35. DOI: 10.1007/978-3-031-09807-9_2.Peer-Reviewed Original ResearchMeasuring organ motionPET motion correctionFront-end electronicsScintillation detectorOrgan motionMotion correctionAttenuation correctionPET/MR scannersAbility of MRISimultaneous imaging modalityPET/MR technologyAttenuation propertiesHybrid PET/MR scannerPET/MRPre-clinicalImaging modalitiesClinical applicationMRIOrgan systemsCardiac applicationsImaging opportunitiesCorrectionDetectorSpatiotemporal resolutionElectron
2021
High-Resolution Label-Free Molecular Imaging of Brain Tumor
Guo R, Ma C, Li Y, Zhao Y, Wang T, Li Y, Fakhri G, Liang Z. High-Resolution Label-Free Molecular Imaging of Brain Tumor. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2021, 00: 3049-3052. PMID: 34891886, DOI: 10.1109/embc46164.2021.9630623.Peer-Reviewed Original ResearchConceptsMagnetic resonance spectroscopic imagingBrain tumorsIntra-tumoural metabolic heterogeneityAssessment of treatment efficacySmall-sized tumorsClinical applicationN-acetyl aspartateBrain tumor characterizationPotential clinical applicationsApplication of magnetic resonance spectroscopic imagingTumor characterizationMolecular imaging techniquesBrain metabolitesImaging of brain tumorsTumorTreatment efficacyClinical relevanceMetabolic imagingDiagnosed brain tumorsHigh-resolution metabolic imagingMetabolic heterogeneityTumor detectionMolecular imaging of brain tumorsLabel-free molecular imagingLabel-free molecular imaging techniqueQuantitative PET in the 2020s: a roadmap
Meikle S, Sossi V, Roncali E, Cherry S, Banati R, Mankoff D, Jones T, James M, Sutcliffe J, Ouyang J, Petibon Y, Ma C, El Fakhri G, Surti S, Karp J, Badawi R, Yamaya T, Akamatsu G, Schramm G, Rezaei A, Nuyts J, Fulton R, Kyme A, Lois C, Sari H, Price J, Boellaard R, Jeraj R, Bailey D, Eslick E, Willowson K, Dutta J. Quantitative PET in the 2020s: a roadmap. Physics In Medicine And Biology 2021, 66: 06rm01. PMID: 33339012, PMCID: PMC9358699, DOI: 10.1088/1361-6560/abd4f7.Peer-Reviewed Original ResearchMeSH KeywordsArtificial IntelligenceHistory, 20th CenturyHistory, 21st CenturyHumansImage Processing, Computer-AssistedImaging, Three-DimensionalKineticsMedical OncologyNeoplasmsPositron Emission Tomography Computed TomographyPositron-Emission TomographyPrognosisRadiopharmaceuticalsSystems BiologyTomography, X-Ray ComputedConceptsTime-of-flight positron emission tomographyStatistical image reconstructionTotal-body positron emission tomographyPositron emission tomographyQuantitative positron emission tomographyImage reconstructionWhole-body positron emission tomographySensitivity of positron emission tomographyCapabilities of positron emission tomographyImage qualityClinical applicationTracer principleRelevant parametersOncology applicationsPhysicsStatistical qualityExpansion of applicationsEmission tomographyClinical practicePET/MRBiologically relevant parametersSensitive biomarkerPositron
2019
Free-Breathing Three-Dimensional T1 Mapping of the Heart Using Subspace-Based Data Acquisition and Image Reconstruction
Han P, Horng D, Marin T, Petibon Y, Ouyang J, Fakhri G, Ma C. Free-Breathing Three-Dimensional T1 Mapping of the Heart Using Subspace-Based Data Acquisition and Image Reconstruction. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2019, 00: 4008-4011. PMID: 31946750, DOI: 10.1109/embc.2019.8856511.Peer-Reviewed Original ResearchConceptsRespiratory motionRespiratory gatingLongitudinal relaxation timeSubspace-based methodsLow-rank tensorMagnetic resonance imagingRelaxation timeT1 mappingT)-spaceSubspace-basedSparsity constraintDynamic MR imagingReconstructed mapsSpatiotemporal correlationThree-dimensionalCardiac MRHealthy subjectsIn vivo dataMagnetizationResonance imagingImage functionMR imagingData acquisitionClinical applicationTensor
2017
Speech Map: a statistical multimodal atlas of 4D tongue motion during speech from tagged and cine MR images
Woo J, Xing F, Stone M, Green J, Reese T, Brady T, Wedeen V, Prince J, Fakhri G. Speech Map: a statistical multimodal atlas of 4D tongue motion during speech from tagged and cine MR images. Computer Methods In Biomechanics And Biomedical Engineering Imaging & Visualization 2017, 7: 361-373. PMID: 31328049, PMCID: PMC6640640, DOI: 10.1080/21681163.2017.1382393.Peer-Reviewed Original ResearchMotion fieldMotion estimationTongue motionAnatomical configurationComplex motion fieldsCourse of speechCine MR imagingMotion informationInternal motionsGlossectomy patientsHealthy subjectsCine MRITongue functionMR imagingSpeech mappingClinical applicationAnatomical referenceTime course of speechTime courseSpeechSingle-scan rest/stress imaging: validation in a porcine model with 18F-Flurpiridaz
Guehl N, Normandin M, Wooten D, Rozen G, Sitek A, Ruskin J, Shoup T, Ptaszek L, El Fakhri G, Alpert N. Single-scan rest/stress imaging: validation in a porcine model with 18F-Flurpiridaz. European Journal Of Nuclear Medicine And Molecular Imaging 2017, 44: 1538-1546. PMID: 28365789, DOI: 10.1007/s00259-017-3684-6.Peer-Reviewed Original ResearchConceptsMyocardial blood flowMicrosphere flow measurementsBlood flowStress myocardial blood flowSingle-scan protocolClinical applicationShort-axis viewMyocardial blood flow measurementsPET dataBlood flow changesIntroduction of adenosineHalf-life of 18FAdenosine infusionRadiotracer injectionAxis viewMyocardial segmentsHealthy pigsClinical translationPET acquisitionTwo-injectionPig modelIschemic areaPorcine modelHalf-lifeAdenosine
2002
Quantitative Simultaneous 99MTc/123I Spect: Design Study and Validation With Monte Carlo Simulations and Physical Acquisitions
Fakhri G, Maksud P, Kijewski M, Zimmerman R, Moore S. Quantitative Simultaneous 99MTc/123I Spect: Design Study and Validation With Monte Carlo Simulations and Physical Acquisitions. IEEE Transactions On Nuclear Science 2002, 49: 2315. DOI: 10.1109/tns.2002.803819.Peer-Reviewed Original ResearchMonte Carlo simulationsBrain phantomCarlo simulationsSimultaneous dual-isotope imagingIterative ordered subsetsDigital brain phantomDual-isotope SPECT studyVariable collimator responseArtificial neural networkPhysical acquisitionEnergy windowNonuniform attenuationCollimator responseDual-isotope imagingPhantom acquisitionsScatter correctionClinical cameraNeural networkMontePhantomIsotope imagingCorrected projectionsSPECT studiesProjector/backprojectorClinical application