2019
MR-based cardiac and respiratory motion correction of PET: application to static and dynamic cardiac 18F-FDG imaging
Petibon Y, Sun T, Han P, Ma C, Fakhri G, Ouyang J. MR-based cardiac and respiratory motion correction of PET: application to static and dynamic cardiac 18F-FDG imaging. Physics In Medicine And Biology 2019, 64: 195009. PMID: 31394518, PMCID: PMC7007962, DOI: 10.1088/1361-6560/ab39c2.Peer-Reviewed Original ResearchConceptsMR-based motion correctionRespiratory motion correctionMotion correctionImproved spatial resolutionReconstructed activity concentrationCardiac PET dataSpatial resolutionCoincidence eventsMR-basedPET imagingContrast-to-noise ratioCardiac PET imagingRespiratory phasesMC dataImprove image qualityMR acquisitionQuantitative accuracyCardiac PETPET dataActivity concentrationsMyocardium wallF-FDG PETDynamics studiesImage qualityMotion artifactsBulk motion detection and correction using list-mode data for cardiac PET imaging
Sun T, Petibon Y, Han P, Ma C, Kim S, Alpert N, Fakhri G, Ouyang J. Bulk motion detection and correction using list-mode data for cardiac PET imaging. Proceedings Of SPIE--the International Society For Optical Engineering 2019, 11072: 110722f-110722f-5. DOI: 10.1117/12.2534701.Peer-Reviewed Original ResearchList-mode dataCardiac PET imagingPET list-mode dataMotion-corrected imagesLines of responsePET imaging applicationsCardiac PETImage qualityBulk motionCardiac PET studiesMotion correctionPET imagingBrain PETMotion estimationData-driven approachMotion detectionImaging applicationsImage spaceMoving frameStatic reference frameMotion transformationCorrectionCenter positionMotionReference frame
2013
Cardiac motion compensation and resolution modeling in simultaneous PET-MR: a cardiac lesion detection study
Petibon Y, Ouyang J, Zhu X, Huang C, Reese T, Chun S, Li Q, Fakhri G. Cardiac motion compensation and resolution modeling in simultaneous PET-MR: a cardiac lesion detection study. Physics In Medicine And Biology 2013, 58: 2085-2102. PMID: 23470288, PMCID: PMC3657754, DOI: 10.1088/0031-9155/58/7/2085.Peer-Reviewed Original ResearchConceptsContrast recoveryDetector point spread functionPartial volume effectsK-spaceMotion compensationB-spline registrationLesion-detection studiesCardiac motion compensationPET-MR scannersSimultaneous PET-MRPET contrastIterative reconstruction frameworkPoint spread functionMotion correctionPET countsNon-rigid B-spline registrationCardiac phantomPSF modelPET-MRMotion deblurringReconstruction frameworkSystem matrixCardiac PETSpread functionDefect detection
2009
Reproducibility and Accuracy of Quantitative Myocardial Blood Flow Assessment with 82Rb PET: Comparison with 13N-Ammonia PET
Fakhri G, Kardan A, Sitek A, Dorbala S, Abi-Hatem N, Lahoud Y, Fischman A, Coughlan M, Yasuda T, Di Carli M. Reproducibility and Accuracy of Quantitative Myocardial Blood Flow Assessment with 82Rb PET: Comparison with 13N-Ammonia PET. Journal Of Nuclear Medicine 2009, 50: 1062-1071. PMID: 19525467, PMCID: PMC3133618, DOI: 10.2967/jnumed.104.007831.Peer-Reviewed Original ResearchConceptsCoronary flow reserveMyocardial blood flowQuantitation of myocardial blood flowTime-activity curvesInterobserver reliabilityBaseline myocardial blood flowBlood poolPET studiesAssessment of myocardial perfusionTissue time-activity curvesEstimation of myocardial blood flowMyocardial blood flow quantitationBland-Altman plotsBlood flow assessmentRight ventricular blood poolCompartment analysisMyocardial blood flow assessmentPeak stressVentricular blood poolReproducibility of myocardial blood flowDynamic restCardiac PETEstimation of coronary flow reserveIntraobserver variabilityMyocardial perfusion
2007
Clinical Myocardial Perfusion PET/CT
Di Carli M, Dorbala S, Meserve J, Fakhri G, Sitek A, Moore S. Clinical Myocardial Perfusion PET/CT. Journal Of Nuclear Medicine 2007, 48: 783-793. PMID: 17475968, DOI: 10.2967/jnumed.106.032789.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseMyocardial perfusion PETPerfusion PETDiagnosing obstructive CADClinically useful risk stratificationObstructive coronary artery diseaseAnatomic coronary artery diseaseMyocardial perfusion PET/CTMultivessel coronary artery diseaseLeft ventricular functionEvaluation of patientsQuantify myocardial perfusionVentricular functionIschemic burdenPharmacological stressRisk stratificationCardiac PETArtery diseasePET/CT technologyMyocardial perfusionAttenuation correctionNuclear cardiologyFunctional consequencesSPECTPETPrinciples of Quantitation in Cardiac PET
Moore S, Fakhri G. Principles of Quantitation in Cardiac PET. 2007, 46-70. DOI: 10.1007/978-0-387-38295-1_4.Peer-Reviewed Original Research
2005
Quantitative dynamic cardiac 82Rb PET using generalized factor and compartment analyses.
El Fakhri G, Sitek A, Guérin B, Kijewski M, Di Carli M, Moore S. Quantitative dynamic cardiac 82Rb PET using generalized factor and compartment analyses. Journal Of Nuclear Medicine 2005, 46: 1264-71. PMID: 16085581.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlgorithmsComputer SimulationCoronary Artery DiseaseFeasibility StudiesFemaleHeartHumansImage Interpretation, Computer-AssistedMaleMiddle AgedModels, CardiovascularPositron-Emission TomographyRadiopharmaceuticalsReproducibility of ResultsRubidium RadioisotopesSensitivity and SpecificitySeverity of Illness IndexConceptsMyocardial perfusionAbsolute myocardial perfusionCatheterization resultsMyocardial tissue extractsDipyridamole stressCardiac PETClinical valueMyocardial factorsFactor analysis of dynamic sequencesPatient studiesLVNoninvasive estimationAccurate input functionPatientsCompartment analysisAverage errorPerfusionParametric mappingTissue extractsRV contributionRV