2015
The influence of clopidogrel on ischemia diagnosed by myocardial perfusion stress testing
Jovin IS, Ebisu KA, Oprea AD, Brandt CA, Natale D, Finta LA, Dziura J, Wackers FJ. The influence of clopidogrel on ischemia diagnosed by myocardial perfusion stress testing. Journal Of Nuclear Cardiology 2015, 23: 773-779. PMID: 26338428, DOI: 10.1007/s12350-015-0268-3.Peer-Reviewed Original ResearchMeSH KeywordsCardiotonic AgentsClopidogrelExercise TestFemaleHumansMaleMiddle AgedMyocardial IschemiaMyocardial Perfusion ImagingPrevalenceReproducibility of ResultsRetrospective StudiesSensitivity and SpecificityTiclopidineTomography, Emission-Computed, Single-PhotonTreatment OutcomeConceptsReversible perfusion defectsOdds ratioPerfusion defectsMyocardial perfusion stress testMyocardial perfusion stress testingStress testStress myocardial perfusion scansMyocardial single photon emissionAdenosine stress testInfluence of clopidogrelLikelihood of ischemiaMyocardial perfusion testingUse of clopidogrelCoronary vascular toneExercise stress testMyocardial perfusion scanMyocardial perfusion imagingSingle photon emissionAdenosine receptor antagonistDiagnosis of ischemiaPerfusion scanPerfusion testingVascular toneReceptor antagonistTomography scan
2014
Call for a standard unit of defect size
Wackers F. Call for a standard unit of defect size. Journal Of Nuclear Cardiology 2014, 21: 682-684. PMID: 24715620, DOI: 10.1007/s12350-014-9874-8.Peer-Reviewed Original ResearchFemaleHumansMaleMyocardial Perfusion ImagingSoftwareTomography, Emission-Computed, Single-PhotonVentricular Function, Left
2010
Cardiac Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging Finally Up to Speed?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
Wackers F. Cardiac Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging Finally Up to Speed?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology. Journal Of The American College Of Cardiology 2010, 55: 1975-1978. PMID: 20430270, DOI: 10.1016/j.jacc.2009.12.043.Peer-Reviewed Original ResearchMeSH KeywordsCoronary Artery DiseaseHumansMyocardial Perfusion ImagingSoftwareTomography, Emission-Computed, Single-Photon
2009
Lessons learned from the detection of ischemia in asymptomatic diabetics (DIAD) study
Wackers FJ, Young LH. Lessons learned from the detection of ischemia in asymptomatic diabetics (DIAD) study. Journal Of Nuclear Cardiology 2009, 16: 855-859. PMID: 19685266, DOI: 10.1007/s12350-009-9138-1.Commentaries, Editorials and LettersDetection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging
Senior R, Monaghan M, Main M, Zamorano J, Tiemann K, Agati L, Weissman N, Klein A, Marwick T, Ahmad M, DeMaria A, Zabalgoitia M, Becher H, Kaul S, Udelson J, Wackers F, Walovitch R, Picard M. Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging. European Heart Journal - Cardiovascular Imaging 2009, 10: 26-35. PMID: 19131498, DOI: 10.1093/ejechocard/jen321.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overArea Under CurveContrast MediaCoronary Artery DiseaseDipyridamoleEchocardiography, StressFemaleFluorocarbonsGated Blood-Pool ImagingHumansImage EnhancementImage Interpretation, Computer-AssistedInternational CooperationMaleMiddle AgedObserver VariationROC CurveSensitivity and SpecificityStatistics, NonparametricTomography, Emission-Computed, Single-PhotonYoung AdultConceptsChest pain patientsPain patientsStress echocardiographyPerfusion imagingNon-inferior sensitivityPhase 3 trialCoronary artery diseaseCoronary artery disease detectionQuantitative coronary angiographyNon-inferiority analysisRadionuclide perfusion imagingSingle photon emissionAdverse eventsArtery diseaseCoronary angiographyBlinded cardiologistsClinical reviewDipyridamole stressMyocardial perfusionSPECT perfusionInternational trialRAMP 1Diagnostic performanceSPECTCharacteristic curve
2008
Association of Leukocyte and Neutrophil Counts With Infarct Size, Left Ventricular Function and Outcomes After Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction
Chia S, Nagurney J, Brown D, Raffel O, Bamberg F, Senatore F, Wackers F, Jang I. Association of Leukocyte and Neutrophil Counts With Infarct Size, Left Ventricular Function and Outcomes After Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction. The American Journal Of Cardiology 2008, 103: 333-337. PMID: 19166685, DOI: 10.1016/j.amjcard.2008.09.085.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryDouble-Blind MethodElectrocardiographyFemaleHumansLeukocyte CountMaleMiddle AgedMyocardial InfarctionNeutrophilsPrognosisStroke VolumeTomography, Emission-Computed, Single-PhotonConceptsPrimary percutaneous coronary interventionLeft ventricular ejection fractionPrimary PCIST-segment elevation myocardial infarctionElevation myocardial infarctionLarger infarct sizePercutaneous coronary interventionInfarct sizeNeutrophil countMyocardial infarctionElevated leukocytesLeukocyte countCardiac eventsCoronary interventionFirst ST-segment elevation myocardial infarctionAcute Myocardial Infarction StudyST-elevation myocardial infarctionAssociation of leukocytesComposite cardiac eventsIntracellular calcium modulatorsLeft Ventricular SalvageAdverse cardiac eventsElevated leukocyte countPlacebo-controlled trialMyocardial Infarction StudyUtility of Cardiac Biomarkers in Predicting Infarct Size, Left Ventricular Function, and Clinical Outcome After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction
Chia S, Senatore F, Raffel O, Lee H, Wackers F, Jang I. Utility of Cardiac Biomarkers in Predicting Infarct Size, Left Ventricular Function, and Clinical Outcome After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction. JACC Cardiovascular Interventions 2008, 1: 415-423. PMID: 19463339, DOI: 10.1016/j.jcin.2008.04.010.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryBenzenesulfonatesBiomarkersCardiovascular AgentsCoronary AngiographyCreatine Kinase, MB FormDisease-Free SurvivalFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionMyocardiumPiperazinesPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentStroke VolumeTime FactorsTomography, Emission-Computed, Single-PhotonTreatment OutcomeTroponin ITroponin TUnited StatesVentricular Function, LeftConceptsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionPrimary PCIElevation myocardial infarctionPercutaneous coronary interventionInfarct sizeClinical outcomesMyocardial infarctionCardiac biomarkersCoronary interventionCreatine kinaseCK-MBLarge ST-segment elevation myocardial infarctionTroponin TIntracellular calcium modulatorsLarger infarct sizeVentricular ejection fractionCardiac biomarker levelsLeft ventricular functionComposite clinical eventsTime-concentration curveEVOLVE trialLower LVEFAdverse eventsEjection fractionDifferent manifestations of coronary artery disease by stress SPECT myocardial perfusion imaging, coronary calcium scoring, and multislice CT coronary angiography in asymptomatic patients with type 2 diabetes mellitus
Scholte A, Schuijf J, Kharagjitsingh A, Dibbets-Schneider P, Stokkel M, Jukema J, van der Wall E, Bax J, Wackers F. Different manifestations of coronary artery disease by stress SPECT myocardial perfusion imaging, coronary calcium scoring, and multislice CT coronary angiography in asymptomatic patients with type 2 diabetes mellitus. Journal Of Nuclear Cardiology 2008, 15: 503-509. PMID: 18674717, DOI: 10.1016/j.nuclcard.2008.02.015.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCalcinosisComorbidityCoronary Artery DiseaseDiabetes Mellitus, Type 2FemaleHumansIncidenceMaleMiddle AgedNetherlandsReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedVentricular Dysfunction, LeftConceptsType 2 diabetes mellitusCoronary artery diseaseMSCT coronary angiographyAsymptomatic patientsCoronary angiographyDiabetes mellitusPositive CAC scoreMyocardial perfusion imagingCAC scoreCoronary atherosclerosisArtery diseaseCAC scoringCalcium scoringPerfusion imagingAbnormal diagnostic test resultsSilent coronary artery diseaseStress single-photon emissionCoronary artery calcium scoringMultislice CT coronary angiographyTomography myocardial perfusion imagingStress SPECT myocardial perfusion imagingSilent coronary atherosclerosisSPECT myocardial perfusion imagingRelative prognostic valueTomographic coronary angiography
2007
Highlights of the 2007 Scientific Sessions of the American Society of Nuclear Cardiology San Diego, California, September 6–9, 2007
Russell RR, Abbott BG, Arrighi JA, Bengel FM, Cohen MC, Garcia EV, Hendel RC, Holly TA, Mieres JH, Shaw LJ, Thomas GS, Thompson RC, Wackers FJ, Bax JJ. Highlights of the 2007 Scientific Sessions of the American Society of Nuclear Cardiology San Diego, California, September 6–9, 2007. Journal Of The American College Of Cardiology 2007, 50: 2336-2343. PMID: 18068044, DOI: 10.1016/j.jacc.2007.10.007.Peer-Reviewed Original ResearchCardiovascular DiseasesHumansRadioactive TracersTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedResolution of Asymptomatic Myocardial Ischemia in Patients With Type 2 Diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study
Wackers FJ, Chyun DA, Young LH, Heller GV, Iskandrian AE, Davey JA, Barrett EJ, Taillefer R, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE. Resolution of Asymptomatic Myocardial Ischemia in Patients With Type 2 Diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study. Diabetes Care 2007, 30: 2892-2898. PMID: 17682123, DOI: 10.2337/dc07-1250.Peer-Reviewed Original ResearchConceptsResolution of ischemiaType 2 diabetesDetection of ischemiaNew ischemiaAsymptomatic Diabetics (DIAD) studyCardiovascular risk factorsAsymptomatic myocardial ischemiaAdenosine stress myocardial perfusionRepeat stressIschemia increasesAsymptomatic patientsCardiac eventsMore patientsACE inhibitorsMyocardial ischemiaRisk factorsIntensive treatmentDiabetic studyIschemiaMyocardial perfusionPatientsMedical treatmentDiabetesInitial evaluationGreater increaseHighlights of the 2006 Scientific Sessions of the American Society of Nuclear Cardiology Montreal, Canada, September 7 to 10, 2006
Bax J, Abbott B, Beanlands R, Bengel F, Berman D, Garcia E, Hendel R, Mieres J, Shaw L, Wackers F. Highlights of the 2006 Scientific Sessions of the American Society of Nuclear Cardiology Montreal, Canada, September 7 to 10, 2006. Journal Of The American College Of Cardiology 2007, 49: 502-508. PMID: 17258098, DOI: 10.1016/j.jacc.2006.11.010.Peer-Reviewed Original ResearchCoronary Artery DiseaseHumansPositron-Emission TomographyTomography, Emission-Computed, Single-Photon
2006
American Society of Nuclear Cardiology consensus statement: Reporting of radionuclide myocardial perfusion imaging studies
Hendel R, Wackers F, Berman D, Ficaro E, DePuey E, Klein L, Cerqueira M. American Society of Nuclear Cardiology consensus statement: Reporting of radionuclide myocardial perfusion imaging studies. Journal Of Nuclear Cardiology 2006, 13: e152-e156. PMID: 17174791, DOI: 10.1016/j.nuclcard.2006.08.013.Peer-Reviewed Original ResearchHumansMedical Records Systems, ComputerizedPractice Guidelines as TopicQuality Assurance, Health CareRadioisotopesRadiopharmaceuticalsTomography, Emission-Computed, Single-PhotonUnited StatesVentricular Dysfunction, LeftMyocardial perfusion planar imaging
Tilkemeier P, Wackers F. Myocardial perfusion planar imaging. Journal Of Nuclear Cardiology 2006, 13: e91-e96. PMID: 17174799, DOI: 10.1016/j.nuclcard.2006.08.012.Peer-Reviewed Original ResearchHumansQuality Assurance, Health CareRadiopharmaceuticalsTomography, Emission-Computed, Single-PhotonUnited StatesVentricular Dysfunction, LeftScreening Asymptomatic Diabetic Patients for Coronary Artery Disease Why Not?
Miller T, Redberg R, Wackers F. Screening Asymptomatic Diabetic Patients for Coronary Artery Disease Why Not? Journal Of The American College Of Cardiology 2006, 48: 761-764. PMID: 16904546, DOI: 10.1016/j.jacc.2006.04.076.Peer-Reviewed Original ResearchMeSH KeywordsCoronary Artery DiseaseCost-Benefit AnalysisDecision MakingDiabetes Mellitus, Type 2HumansMass ScreeningPrevalenceRisk AssessmentTomography, Emission-Computed, Single-PhotonTreatment OutcomeConceptsCoronary artery diseaseAsymptomatic diabetic patientsDiabetic patientsArtery diseaseSilent coronary artery diseaseStress single-photon emissionImportant coronary artery diseaseAnti-ischemic medicationNon-diabetic patientsClinical scoring systemAbnormal SPECT imagesSingle photon emissionCardiovascular eventsAggressive treatmentDiabetes statusPatient subsetsHigh prevalenceScreening programElevated riskHigh riskPatientsConsensus documentTrue prevalenceScoring systemDIAD studyTask Force 5: Training in Nuclear Cardiology Endorsed by the American Society of Nuclear Cardiology
Cerqueira M, Berman D, Di Carli M, Schelbert H, Wackers F, Williams K. Task Force 5: Training in Nuclear Cardiology Endorsed by the American Society of Nuclear Cardiology. Journal Of The American College Of Cardiology 2006, 47: 898-904. PMID: 16487871, DOI: 10.1016/j.jacc.2005.12.027.Peer-Reviewed Original ResearchCardiologyEducation, Medical, GraduateHumansNuclear MedicinePositron-Emission TomographyTomography, Emission-Computed, Single-Photon
2005
A Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Intravenous MCC-135 as an Adjunct to Primary Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction: Rationale and Design of the Evaluation of MCC-135 for Left Ventricular Salvage in Acute MI (EVOLVE) Study
Jang I, Pettigrew V, Picard M, Kowey P, Demmel V, Zile M, Tatsuno J, Wackers F, Hibberd M. A Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Intravenous MCC-135 as an Adjunct to Primary Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction: Rationale and Design of the Evaluation of MCC-135 for Left Ventricular Salvage in Acute MI (EVOLVE) Study. Journal Of Thrombosis And Thrombolysis 2005, 20: 147-153. PMID: 16261287, DOI: 10.1007/s11239-005-3267-4.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAdultAngioplasty, Balloon, CoronaryBenzenesulfonatesCalciumDouble-Blind MethodEchocardiographyHumansMaleMiddle AgedMuscle CellsMyocardial InfarctionMyocardial Reperfusion InjuryNecrosisPiperazinesRadiographyTomography, Emission-Computed, Single-PhotonVentricular Function, LeftConceptsPrimary percutaneous coronary interventionST-elevation myocardial infarctionLeft Ventricular SalvageElevation myocardial infarctionPlacebo-controlled clinical trialMCC-135Percutaneous coronary interventionIntracellular calcium overloadMyocardial infarctionPost-myocardial infarctionVentricular functionCalcium overloadEVOLVE studyCoronary interventionAdjunct therapyInfarct sizeClinical trialsPrimary PCIAcute ST-elevation myocardial infarctionMI studiesVentricular ejection fractionSerum cardiac markersAcute myocardial infarctionEarly clinical studiesMyocardial infarction sizeClinical validation of SPECT attenuation correction using x-ray computed tomography–derived attenuation maps: Multicenter clinical trial with angiographic correlation
Masood Y, Liu Y, DePuey G, Taillefer R, Araujo LI, Allen S, Delbeke D, Anstett F, Peretz A, Zito M, Tsatkin V, Wackers FJ. Clinical validation of SPECT attenuation correction using x-ray computed tomography–derived attenuation maps: Multicenter clinical trial with angiographic correlation. Journal Of Nuclear Cardiology 2005, 12: 676-686. PMID: 16344230, DOI: 10.1016/j.nuclcard.2005.08.006.Peer-Reviewed Original ResearchOn the bright right side
Wackers F. On the bright right side. Journal Of Nuclear Cardiology 2005, 12: 378-380. PMID: 16084425, DOI: 10.1016/j.nuclcard.2005.05.005.Peer-Reviewed Original ResearchHeart VentriclesHumansMyocardial IschemiaPractice Guidelines as TopicPractice Patterns, Physicians'Tomography, Emission-Computed, Single-PhotonVentricular Dysfunction, RightVentriculography, First-PassNew hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: Methodology and validation
Liu YH, Sinusas AJ, Khaimov D, Gebuza BI, Wackers FJ. New hybrid count- and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: Methodology and validation. Journal Of Nuclear Cardiology 2005, 12: 55-65. PMID: 15682366, DOI: 10.1016/j.nuclcard.2004.09.015.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsElectrocardiographyFemaleGated Blood-Pool ImagingHumansImage Interpretation, Computer-AssistedMaleMiddle AgedPhantoms, ImagingReproducibility of ResultsSensitivity and SpecificitySeverity of Illness IndexStroke VolumeTomography, Emission-Computed, Single-PhotonVentricular Dysfunction, Left
2004
Randomized, Controlled Dose-Ranging Study of the Selective Adenosine A2A Receptor Agonist Binodenoson for Pharmacological Stress as an Adjunct to Myocardial Perfusion Imaging
Udelson J, Heller G, Wackers F, Chai A, Hinchman D, Coleman P, Dilsizian V, DiCarli M, Hachamovitch R, Johnson J, Barrett R, Gibbons R. Randomized, Controlled Dose-Ranging Study of the Selective Adenosine A2A Receptor Agonist Binodenoson for Pharmacological Stress as an Adjunct to Myocardial Perfusion Imaging. Circulation 2004, 109: 457-464. PMID: 14734517, DOI: 10.1161/01.cir.0000114523.03312.7d.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAdenosine A2 Receptor AgonistsAgedCoronary Artery DiseaseCoronary CirculationCross-Over StudiesDose-Response Relationship, DrugFemaleHumansMalePerfusionTomography, Emission-Computed, Single-PhotonVasodilator AgentsConceptsReversible perfusion defectsDose-related reductionAdenosine receptor stimulationSide effectsPharmacological stressPerfusion defectsReceptor stimulationFrequent side effectsSubjective side effectsDose-Ranging StudyMyocardial perfusion imagingAdenosine A2A receptorsSingle photon emissionChest painCoronary vasodilationCrossover trialBinodenosonA2A receptorsPerfusion imagingSelective agonismRandom orderSeverityKappa valuesSimilar degreePhoton emission