1993
Frequency and significance of right ventricular dysfunction during inferior wall left ventricular myocardial infarction treated with thrombolytic therapy (results from the Thrombolysis in Myocardial Infarction [TIMI] II trial)
Berger P, Ruocco N, Ryan T, Jacobs A, Zaret B, Wackers F, Frederick M, Faxon D, Group R. Frequency and significance of right ventricular dysfunction during inferior wall left ventricular myocardial infarction treated with thrombolytic therapy (results from the Thrombolysis in Myocardial Infarction [TIMI] II trial). The American Journal Of Cardiology 1993, 71: 1148-1152. PMID: 8097614, DOI: 10.1016/0002-9149(93)90637-r.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAngioplasty, Balloon, CoronaryCombined Modality TherapyConstriction, PathologicCoronary VesselsFemaleHeart DiseasesHeart VentriclesHumansMaleMiddle AgedMyocardial InfarctionRadionuclide VentriculographyThrombolytic TherapyTissue Plasminogen ActivatorVentricular Function, LeftVentricular Function, RightConceptsRV wall motion abnormalitiesRight ventricular dysfunctionRV dysfunctionVentricular myocardial infarctionWall motion abnormalitiesVentricular dysfunctionThrombolytic therapyRadionuclide ventriculographyMyocardial infarctionMotion abnormalitiesInferior wallLower mean left ventricular ejection fractionMean left ventricular ejection fractionLeft ventricular ejection fractionBaseline clinical characteristicsInfarct-related arteryMyocardial Infarction (TIMI) II trialVentricular ejection fractionEquilibrium radionuclide ventriculographyHospital complicationsMultivessel diseaseII trialClinical characteristicsHospital dischargeEjection fraction
1990
Comparison of immediate invasive, delayed invasive, and conservative strategies after tissue-type plasminogen activator. Results of the Thrombolysis in Myocardial Infarction (TIMI) Phase II-A trial.
Rogers W, Baim D, Gore J, Brown B, Roberts R, Williams D, Chesebro J, Babb J, Sheehan F, Wackers F. Comparison of immediate invasive, delayed invasive, and conservative strategies after tissue-type plasminogen activator. Results of the Thrombolysis in Myocardial Infarction (TIMI) Phase II-A trial. Circulation 1990, 81: 1457-1476. PMID: 2110033, DOI: 10.1161/01.cir.81.5.1457.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCombined Modality TherapyCoronary AngiographyCoronary Artery BypassExercise TestFemaleHumansMaleMiddle AgedMyocardial InfarctionRadionuclide VentriculographyRandomized Controlled Trials as TopicStroke VolumeThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorConceptsCoronary artery bypass graft surgeryPercutaneous transluminal coronary angioplastyInvasive strategy groupConservative-strategy groupAcute myocardial infarctionTreatment groupsPrimary study end pointResidual infarct artery stenosisArtery bypass graft surgeryPatent infarct-related arteryImmediate invasive strategyPredischarge exercise testingSimilar cumulative ratesBypass graft surgeryStudy end pointInfarct-related arteryTransluminal coronary angioplastyVentricular ejection fractionInitial management strategyLong-term outcomesConservative strategyStrategy groupTissue-type plasminogen activatorNonfatal reinfarctionGraft surgery
1989
Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy
Wackers F, Gibbons R, Verani M, Kayden D, Pellikka P, Behrenbeck T, Mahmarian J, Zaret B. Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy. Journal Of The American College Of Cardiology 1989, 14: 861-873. PMID: 2507612, DOI: 10.1016/0735-1097(89)90456-7.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorAcute myocardial infarctionPatent infarct-related arteryInfarct-related arteryThallium-201 imagingThrombolytic therapyMyocardial infarctionPlanar technetiumMyocardial perfusionExercise thallium-201 imagingFirst acute myocardial infarctionInfarct-related artery patencyInitial risk areaPersistent coronary occlusionSuccess of reperfusionMyocardial blood flowNew myocardial perfusionTissue-type plasminogen activatorArtery patencyChest painCoronary occlusionRepeat imagingBlood flowInfarctionThallium-201Quantitative radionuclide assessment of regional ventricular function after thrombolytic therapy for acute myocardial infarction: Results of phase I Thrombolysis in Myocardial Infarction (TIMI) trial
Wackers F, Terrin M, Kayden D, Knatterud G, Forman S, Braunwald E, Zaret B, Investigators. Quantitative radionuclide assessment of regional ventricular function after thrombolytic therapy for acute myocardial infarction: Results of phase I Thrombolysis in Myocardial Infarction (TIMI) trial. Journal Of The American College Of Cardiology 1989, 13: 998-1005. PMID: 2494246, DOI: 10.1016/0735-1097(89)90250-7.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorLeft ventricular ejection fractionInfarct-related arteryVentricular ejection fractionGlobal left ventricular ejection fractionRegional left ventricular functionLeft ventricular functionEjection fractionAcute myocardial infarctionRegional ejection fractionVentricular functionMyocardial infarctionMean global left ventricular ejection fractionIntravenous recombinant tissue-type plasminogen activatorRegional left ventricular ejection fractionEffect of thrombolysisMyocardial Infarction trialRegional ventricular functionTissue-type plasminogen activatorPatients 185Sustained reperfusionIntravenous streptokinaseAngiographic reperfusionThrombolytic therapyPatency rates