2024
In vivo neuropil density from anatomical MRI and machine learning
Akif A, Staib L, Herman P, Rothman D, Yu Y, Hyder F. In vivo neuropil density from anatomical MRI and machine learning. Cerebral Cortex 2024, 34: bhae200. PMID: 38771239, PMCID: PMC11107380, DOI: 10.1093/cercor/bhae200.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSynaptic densityNeuropil densityCellular densityArtificial neural networkNeural networkPositron emission tomographyAnatomical magnetic resonance imagingHealthy subjectsSynaptic activityMRI scansMachine learning algorithmsBrain's energy budgetEmission tomographyIn vivo MRI scansResonance imagingTissue cellularityLearning algorithmsDiffusion magnetic resonance imagingMachine learningMicroscopic interpretationInterpretation of functional neuroimaging dataIndividual predictionsSubjectsMultimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization
Vafaii H, Mandino F, Desrosiers-Grégoire G, O’Connor D, Markicevic M, Shen X, Ge X, Herman P, Hyder F, Papademetris X, Chakravarty M, Crair M, Constable R, Lake E, Pessoa L. Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization. Nature Communications 2024, 15: 229. PMID: 38172111, PMCID: PMC10764905, DOI: 10.1038/s41467-023-44363-z.Peer-Reviewed Original Research
2023
A consensus protocol for functional connectivity analysis in the rat brain
Grandjean J, Desrosiers-Gregoire G, Anckaerts C, Angeles-Valdez D, Ayad F, Barrière D, Blockx I, Bortel A, Broadwater M, Cardoso B, Célestine M, Chavez-Negrete J, Choi S, Christiaen E, Clavijo P, Colon-Perez L, Cramer S, Daniele T, Dempsey E, Diao Y, Doelemeyer A, Dopfel D, Dvořáková L, Falfán-Melgoza C, Fernandes F, Fowler C, Fuentes-Ibañez A, Garin C, Gelderman E, Golden C, Guo C, Henckens M, Hennessy L, Herman P, Hofwijks N, Horien C, Ionescu T, Jones J, Kaesser J, Kim E, Lambers H, Lazari A, Lee S, Lillywhite A, Liu Y, Liu Y, López -Castro A, López-Gil X, Ma Z, MacNicol E, Madularu D, Mandino F, Marciano S, McAuslan M, McCunn P, McIntosh A, Meng X, Meyer-Baese L, Missault S, Moro F, Naessens D, Nava-Gomez L, Nonaka H, Ortiz J, Paasonen J, Peeters L, Pereira M, Perez P, Pompilus M, Prior M, Rakhmatullin R, Reimann H, Reinwald J, Del Rio R, Rivera-Olvera A, Ruiz-Pérez D, Russo G, Rutten T, Ryoke R, Sack M, Salvan P, Sanganahalli B, Schroeter A, Seewoo B, Selingue E, Seuwen A, Shi B, Sirmpilatze N, Smith J, Smith C, Sobczak F, Stenroos P, Straathof M, Strobelt S, Sumiyoshi A, Takahashi K, Torres-García M, Tudela R, van den Berg M, van der Marel K, van Hout A, Vertullo R, Vidal B, Vrooman R, Wang V, Wank I, Watson D, Yin T, Zhang Y, Zurbruegg S, Achard S, Alcauter S, Auer D, Barbier E, Baudewig J, Beckmann C, Beckmann N, Becq G, Blezer E, Bolbos R, Boretius S, Bouvard S, Budinger E, Buxbaum J, Cash D, Chapman V, Chuang K, Ciobanu L, Coolen B, Dalley J, Dhenain M, Dijkhuizen R, Esteban O, Faber C, Febo M, Feindel K, Forloni G, Fouquet J, Garza-Villarreal E, Gass N, Glennon J, Gozzi A, Gröhn O, Harkin A, Heerschap A, Helluy X, Herfert K, Heuser A, Homberg J, Houwing D, Hyder F, Ielacqua G, Jelescu I, Johansen-Berg H, Kaneko G, Kawashima R, Keilholz S, Keliris G, Kelly C, Kerskens C, Khokhar J, Kind P, Langlois J, Lerch J, López-Hidalgo M, Manahan-Vaughan D, Marchand F, Mars R, Marsella G, Micotti E, Muñoz-Moreno E, Near J, Niendorf T, Otte W, Pais-Roldán P, Pan W, Prado-Alcalá R, Quirarte G, Rodger J, Rosenow T, Sampaio-Baptista C, Sartorius A, Sawiak S, Scheenen T, Shemesh N, Shih Y, Shmuel A, Soria G, Stoop R, Thompson G, Till S, Todd N, Van Der Linden A, van der Toorn A, van Tilborg G, Vanhove C, Veltien A, Verhoye M, Wachsmuth L, Weber-Fahr W, Wenk P, Yu X, Zerbi V, Zhang N, Zhang B, Zimmer L, Devenyi G, Chakravarty M, Hess A. A consensus protocol for functional connectivity analysis in the rat brain. Nature Neuroscience 2023, 26: 673-681. PMID: 36973511, PMCID: PMC10493189, DOI: 10.1038/s41593-023-01286-8.Peer-Reviewed Original Research
2022
A 3D atlas of functional human brain energetic connectome based on neuropil distribution
Yu Y, Akif A, Herman P, Cao M, Rothman D, Carson R, Agarwal D, Evans A, Hyder F. A 3D atlas of functional human brain energetic connectome based on neuropil distribution. Cerebral Cortex 2022, 33: 3996-4012. PMID: 36104858, PMCID: PMC10068297, DOI: 10.1093/cercor/bhac322.Peer-Reviewed Original ResearchConceptsSynaptic densityCortical regionsHigher synapse densityHuman cortical circuitsFunctional imaging studiesCortical activity mapsVivo PET imagingNeuropil distributionGlucose oxidationSynapse densityCortical circuitsMetabolic rateSynaptic connectionsCortical energeticsImaging studiesHuman cortexPET imagingHistological stainingRecent evidenceCortexHuman brainBrainVoxel levelActivity ratesAtlas
2016
Chapter 5 New horizons in neurometabolic and neurovascular coupling from calibrated fMRI
Shu CY, Sanganahalli BG, Coman D, Herman P, Hyder F. Chapter 5 New horizons in neurometabolic and neurovascular coupling from calibrated fMRI. Progress In Brain Research 2016, 225: 99-122. PMID: 27130413, DOI: 10.1016/bs.pbr.2016.02.003.Peer-Reviewed Original ResearchConceptsNeurovascular couplingFunctional MRINeuronal activityBlood oxygenation level-dependent (BOLD) signalFunctional brain activationLevel-dependent signalNeurometabolic couplingEffective therapyBlood flowNeuroimaging toolsHealth conditionsPowerful neuroimaging toolBrain activationBOLD signalNeural activityBOLD contrastMetabolic demandsOxygen consumptionDependent signalsTherapyMicrovesselsMRIActivityBiomarkers
2014
Insights from Neuroenergetics into the Interpretation of Functional Neuroimaging: An Alternative Empirical Model for Studying the Brain's Support of Behavior
Shulman RG, Hyder F, Rothman DL. Insights from Neuroenergetics into the Interpretation of Functional Neuroimaging: An Alternative Empirical Model for Studying the Brain's Support of Behavior. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 1721-1735. PMID: 25160670, PMCID: PMC4269754, DOI: 10.1038/jcbfm.2014.145.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMagnetic resonance imagingNeuronal activityMental moduleObservable behaviorBrain activityDistinct psychological mechanismsResonance imagingBaseline neuronal activityPositron emission tomography (PET) imagingEmission Tomography ImagingPsychological mechanismsMental processesFunctional neuroimagingBrain supportAwake humansAlternative empirical modelsNeurophysiological parametersBaseline activityTomography imagingTheoretical assumptionsSensory systemsIncremental signalNeuroimagingElectrical recordings
2013
Anti-epileptogenesis: Electrophysiology, diffusion tensor imaging and behavior in a genetic absence model
van Luijtelaar G, Mishra AM, Edelbroek P, Coman D, Frankenmolen N, Schaapsmeerders P, Covolato G, Danielson N, Niermann H, Janeczko K, Kiemeneij A, Burinov J, Bashyal C, Coquillette M, Lüttjohann A, Hyder F, Blumenfeld H, van Rijn CM. Anti-epileptogenesis: Electrophysiology, diffusion tensor imaging and behavior in a genetic absence model. Neurobiology Of Disease 2013, 60: 126-138. PMID: 23978468, PMCID: PMC3952020, DOI: 10.1016/j.nbd.2013.08.013.Peer-Reviewed Original ResearchConceptsDays post treatmentWAG/Rij ratsCritical treatment periodDuration of ADDepressive-like behaviorDepressive-like symptomsEarly pharmacological treatmentPost treatmentTreatment of patientsWhite matter changesGenetic absence modelCortical network activityDiffusion tensor imagingChronic epilepsySymptom onsetInternal capsulaCortical excitabilityPharmacological treatmentDecreased immobilitySwim testControl ratsTreatment periodCorpus callosumMatter changesPotential amplitudeIn vivo three‐dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution
Coman D, de Graaf R, Rothman DL, Hyder F. In vivo three‐dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution. NMR In Biomedicine 2013, 26: 1589-1595. PMID: 23881869, PMCID: PMC3800475, DOI: 10.1002/nbm.2995.Peer-Reviewed Original ResearchConceptsK-spaceNonexchanging protonsThree-dimensional molecular imagingParamagnetic lanthanide ionsRedundant deviationChemical shift imagingField of viewMolecular imaging capabilitiesMolecular imagingRapid data acquisitionProton detectionLanthanide ionsTens of minutesImaging capabilitiesMacrocyclic chelatesSpectroscopic signalsMacrocyclicCSI experimentsRelaxation timeHigh spatiotemporal resolutionParamagnetic agentsIncreased resting functional connectivity in spike‐wave epilepsy in WAG/Rij rats
Mishra AM, Bai X, Motelow JE, DeSalvo MN, Danielson N, Sanganahalli BG, Hyder F, Blumenfeld H. Increased resting functional connectivity in spike‐wave epilepsy in WAG/Rij rats. Epilepsia 2013, 54: 1214-1222. PMID: 23815571, PMCID: PMC3703864, DOI: 10.1111/epi.12227.Peer-Reviewed Original ResearchConceptsSpike-wave dischargesWAG/RijFunctional connectivityNonepileptic controlsAbsence epilepsyEpileptic WAG/RijBrain networksWAG/Rij ratsChronic seizure activitySpike-wave epilepsyHuman absence seizuresChildhood absence epilepsyWistar Albino GlaxoActivity-dependent plasticityCortical-cortical connectivityFunctional magnetic resonance imagingMagnetic resonance imagingNonepileptic animalsSeizure activitySpontaneous episodesWistar controlsAbsence seizuresAdjacent cortexChronic changesAnimal modelsFunctional MRI and neural responses in a rat model of Alzheimer's disease
Sanganahalli BG, Herman P, Behar KL, Blumenfeld H, Rothman DL, Hyder F. Functional MRI and neural responses in a rat model of Alzheimer's disease. NeuroImage 2013, 79: 404-411. PMID: 23648961, PMCID: PMC3700380, DOI: 10.1016/j.neuroimage.2013.04.099.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseFunctional magnetic resonance imagingCerebral cortexAD brainSomatosensory cortexRat modelCortical functionNeural responsesAge-matched healthy controlsAD rat modelContralateral somatosensory cortexSensory-evoked responsesHigh-field functional magnetic resonance imagingBrain functional responsesMagnetic resonance imagingAD ratsControl ratsHealthy controlsThalamic responsesNormal ratsCortical responsesAD modelSubcortical functionBrain plaquesElectrical stimulationLactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia
Herzog RI, Jiang L, Herman P, Zhao C, Sanganahalli BG, Mason GF, Hyder F, Rothman DL, Sherwin RS, Behar KL. Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. Journal Of Clinical Investigation 2013, 123: 1988-1998. PMID: 23543056, PMCID: PMC3638906, DOI: 10.1172/jci65105.Peer-Reviewed Original ResearchConceptsAntecedent recurrent hypoglycemiaRecurrent hypoglycemiaHypoglycemic conditionsIntensive insulin therapyTight glycemic controlType 2 diabetesInsulin therapyGlycemic controlBrain metabolismElevated lactateNeuronal metabolismRodent modelsNeuronal activityGlucose metabolismHypoglycemiaLactate uptakeNeuronal functionType 1Metabolic regulatorOxidative capacityModest incrementLactateMetabolismUnexpected findingBrain
2012
Quantitative fMRI and oxidative neuroenergetics
Hyder F, Rothman DL. Quantitative fMRI and oxidative neuroenergetics. NeuroImage 2012, 62: 985-994. PMID: 22542993, PMCID: PMC3389300, DOI: 10.1016/j.neuroimage.2012.04.027.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingNeuronal activityQuantitative functional magnetic resonance imagingTotal neuronal activityBlood oxygenation level-dependent (BOLD) signalBrain energy metabolismResting-state paradigmLevel-dependent signalMagnetic resonance imagingSynaptic activityResonance imagingParamagnetic contrast agentFunctional brainBOLD contrastBaseline stateEnergy metabolismFunctional mapsContrast agentsMagnetic resonance spectroscopyFMRI dataRegion of interestActivityNeuroenergeticsBrain
2011
Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat
Mishra AM, Ellens DJ, Schridde U, Motelow JE, Purcaro MJ, DeSalvo MN, Enev M, Sanganahalli BG, Hyder F, Blumenfeld H. Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat. Journal Of Neuroscience 2011, 31: 15053-15064. PMID: 22016539, PMCID: PMC3432284, DOI: 10.1523/jneurosci.0101-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain MappingBrain WavesCerebral CortexCerebrovascular CirculationCorpus StriatumDisease Models, AnimalElectroencephalographyElectrophysiologyEpilepsyImage Processing, Computer-AssistedLaser-Doppler FlowmetryMagnetic Resonance ImagingNicotinic AntagonistsOxygenRatsRats, WistarThalamusTubocurarineVibrissaeConceptsCerebral blood flowCerebral blood volumeLocal field potentialsNeuronal activityLaser Doppler cerebral blood flowSubcortical structuresWAG/Rij ratsNeuronal activity decreasesHuman absence epilepsySpike-wave dischargesWAG/RijMultiunit activity recordingsFMRI signalsFunctional magnetic resonance imaging (fMRI) signalsMagnetic resonance imaging signalsFMRI decreasesCBF decreaseHemodynamic changesCerebral cortexBasal gangliaSomatosensory cortexAbsence epilepsyWhisker stimulationBlood flowAnimal modelsNeuroanatomical changes in a mouse model of early life neglect
Duque A, Coman D, Carlyle BC, Bordner KA, George ED, Papademetris X, Hyder F, Simen AA. Neuroanatomical changes in a mouse model of early life neglect. Brain Structure And Function 2011, 217: 459-472. PMID: 21984312, PMCID: PMC3664301, DOI: 10.1007/s00429-011-0350-9.Peer-Reviewed Original ResearchConceptsMouse modelNeuroanatomical changesEarly life neglectNovel mouse modelNovel animal modelWhite matter disorganizationMaternal separationCortical thicknessAdult miceAnimal modelsBehavioral abnormalitiesInter-hemispheric asymmetrySmall brain sizeSubcortical structuresPharmacological experimentationProtein expressionLeft hemisphereEarly weaningHuman survivorsAbnormalitiesCurrent knowledgeBrain sizeConcomitant changesAtrophyEvidence for the importance of measuring total brain activity in neuroimaging
Hyder F, Rothman DL. Evidence for the importance of measuring total brain activity in neuroimaging. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 5475-5476. PMID: 21441108, PMCID: PMC3078349, DOI: 10.1073/pnas.1102026108.Peer-Reviewed Original Research
2010
Neuronal correlate of BOLD signal fluctuations at rest: Err on the side of the baseline
Hyder F, Rothman DL. Neuronal correlate of BOLD signal fluctuations at rest: Err on the side of the baseline. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 10773-10774. PMID: 20534504, PMCID: PMC2890714, DOI: 10.1073/pnas.1005135107.Peer-Reviewed Original ResearchBrain temperature by Biosensor Imaging of Redundant Deviation in Shifts (BIRDS): comparison between TmDOTP5−and TmDOTMA−
Coman D, Trubel HK, Hyder F. Brain temperature by Biosensor Imaging of Redundant Deviation in Shifts (BIRDS): comparison between TmDOTP5−and TmDOTMA−. NMR In Biomedicine 2010, 23: 277-285. PMID: 19957287, PMCID: PMC2843767, DOI: 10.1002/nbm.1461.Peer-Reviewed Original Research
2009
Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent
Coman D, Trubel HK, Rycyna RE, Hyder F. Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent. NMR In Biomedicine 2009, 22: 229-239. PMID: 19130468, PMCID: PMC2735415, DOI: 10.1002/nbm.1312.Peer-Reviewed Original Research
2001
Lactate efflux and the neuroenergetic basis of brain function
Shulman R, Hyder F, Rothman D. Lactate efflux and the neuroenergetic basis of brain function. NMR In Biomedicine 2001, 14: 389-396. PMID: 11746930, DOI: 10.1002/nbm.741.Peer-Reviewed Original ResearchQuantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI
Hyder F, Kida I, Behar K, Kennan R, Maciejewski P, Rothman D. Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI. NMR In Biomedicine 2001, 14: 413-431. PMID: 11746934, DOI: 10.1002/nbm.733.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingNeuronal activityBOLD functional MRIFunctional MRICerebral cortexPharmacological treatmentGlutamate release inhibitorNeuronal glucose oxidationRat cerebral cortexRelease of glutamateRat forepaw stimulation modelFMRI signalsFunctional magnetic resonance imagingQuantitative magnetic resonance imagingBlood oxygenation levelBOLD fMRI studiesEnergy metabolismBOLD fMRI signalMulti-modal magnetic resonance imagingGlutamatergic neuronsRelease inhibitorChannel blockersRat brainOxygen deliveryNeurochemical basis