2024
Outcomes of repeat conventional transarterial chemoembolization in patients with liver metastases
Ghabili K, Windham-Herman A, Konstantinidis M, Murali N, Borde T, Adam L, Laage-Gaupp F, Lin M, Chapiro J, Georgiades C, Nezami N. Outcomes of repeat conventional transarterial chemoembolization in patients with liver metastases. Annals Of Hepatology 2024, 29: 101529. PMID: 39033928, PMCID: PMC11558520, DOI: 10.1016/j.aohep.2024.101529.Peer-Reviewed Original ResearchConventional transarterial chemoembolizationLiver metastasesNeuroendocrine tumorsColorectal carcinomaTransarterial chemoembolizationOverall survivalLung cancerAssociated with improved patient survivalManagement of liver metastasesMetastatic liver lesionsSingle-institution analysisNonresponding patientsSurvival outcomesPatient survivalResponse assessmentTarget lesionsMetastasisLiver lesionsPatientsResponse rateChemoembolizationSurvivalLiverLesionsCancerAssessing interventional radiology specialty knowledge and perception amongst Tanzanian medical students before and after exposure to an immersive curriculum
Alswang J, Musa B, Fawzy N, Ahmad B, Mbuguje E, Naif A, Ashrafian H, Laage Gaupp F, Ramalingam V, Shaygi B. Assessing interventional radiology specialty knowledge and perception amongst Tanzanian medical students before and after exposure to an immersive curriculum. Clinical Radiology 2024, 79: e1081-e1087. PMID: 38824041, DOI: 10.1016/j.crad.2024.04.020.Peer-Reviewed Original ResearchCreating a Sustainable Foundation for IR Services and Training in Sub-Saharan Africa: 5-Year Update on the Road2IR Initiative
Alswang J, Mbuguje E, Chan S, Ak M, Naif A, Rukundo I, Minja F, Newsome J, Ramalingam V, Laage Gaupp F. Creating a Sustainable Foundation for IR Services and Training in Sub-Saharan Africa: 5-Year Update on the Road2IR Initiative. Journal Of Vascular And Interventional Radiology 2024, 35: 1049-1056. PMID: 38513756, DOI: 10.1016/j.jvir.2024.03.015.Peer-Reviewed Original ResearchTechnical success rateMinimally invasive procedureInterventional radiology serviceSub-Saharan AfricaClinical outcomesProcedural dataResource-constrained settingsInvasive proceduresIR physiciansPrimary operationTeaching hospitalSuccess rateSub-SaharanStudy periodComplicationsProcedure classNon-vascularHands-on trainingRadiology servicesFive-yearAn International Collaboration in Interventional Radiology Training: Cultivating Knowledge and Fostering Interest Among Radiology Residents in East Africa
Musa B, Fawzy N, Gandhi A, Alswang J, Mbuguje E, Naif A, Mutonga M, Asadi H, Laage Gaupp F, Ramalingam V, Shaygi B. An International Collaboration in Interventional Radiology Training: Cultivating Knowledge and Fostering Interest Among Radiology Residents in East Africa. CardioVascular And Interventional Radiology 2024, 47: 517-519. PMID: 38361009, DOI: 10.1007/s00270-024-03665-5.Peer-Reviewed Original Research
2023
Assessment of Required Patient Travel to Receive Interventional Radiology Services in the Resource-Limited Setting of Tanzania
Alswang J, Mbuguje E, Naif A, Musa B, Laage Gaupp F, Ramalingam V. Assessment of Required Patient Travel to Receive Interventional Radiology Services in the Resource-Limited Setting of Tanzania. Journal Of Vascular And Interventional Radiology 2023, 34: 2213-2217. PMID: 37619942, DOI: 10.1016/j.jvir.2023.08.008.Peer-Reviewed Original ResearchComparative Analysis of Percutaneous Drainage versus Operative Drainage of Intra-Abdominal Abscesses in a Resource-Limited Setting: The Tanzanian Experience
Ukweh O, Alswang J, Iya-Benson J, Naif A, Chan S, Laage-Gaupp F, Asch M, Ramalingam V. Comparative Analysis of Percutaneous Drainage versus Operative Drainage of Intra-Abdominal Abscesses in a Resource-Limited Setting: The Tanzanian Experience. Annals Of Global Health 2023, 89: 35. PMID: 37273489, PMCID: PMC10237249, DOI: 10.5334/aogh.4070.Peer-Reviewed Original ResearchConceptsIntra-abdominal abscessPercutaneous abscess drainageSurgical abscess drainageNational Referral HospitalTechnical success rateAbscess drainageInterventional radiologyImage-guided percutaneous abscess drainageRetrospective cohort studyHigh technical successStandard of careSuccess rateManual chart reviewResource limited settingsResource-limited settingsChart reviewCohort studyComplication rateOperative drainagePercutaneous drainageReferral hospitalClinical outcomesProcedural dataPAD groupTechnical success
2022
Night Watch: Positive Effect of a Night Float Call System on IR Resident Wellness
Chan SM, Laage Gaupp FM, Green CS, Malpani R, Madoff DC. Night Watch: Positive Effect of a Night Float Call System on IR Resident Wellness. Journal Of Vascular And Interventional Radiology 2022, 33: 1616-1618. PMID: 36049663, DOI: 10.1016/j.jvir.2022.08.025.Peer-Reviewed Original ResearchGlobal Health and Interventional Radiology: Ethical Considerations
Chan S, Laage Gaupp F, Rockwell H, Perez A, Rukundo I, Keller E. Global Health and Interventional Radiology: Ethical Considerations. CardioVascular And Interventional Radiology 2022, 45: 1881-1883. PMID: 35918432, DOI: 10.1007/s00270-022-03236-6.Peer-Reviewed Original ResearchOptimization of the BCLC Staging System for Locoregional Therapy for Hepatocellular Carcinoma by Using Quantitative Tumor Burden Imaging Biomarkers at MRI.
Borde T, Nezami N, Laage Gaupp F, Savic LJ, Taddei T, Jaffe A, Strazzabosco M, Lin M, Duran R, Georgiades C, Hong K, Chapiro J. Optimization of the BCLC Staging System for Locoregional Therapy for Hepatocellular Carcinoma by Using Quantitative Tumor Burden Imaging Biomarkers at MRI. Radiology 2022, 304: 228-237. PMID: 35412368, PMCID: PMC9270683, DOI: 10.1148/radiol.212426.Peer-Reviewed Original ResearchConceptsMedian overall survivalAdvanced-stage hepatocellular carcinomaTransarterial chemoembolizationHepatocellular carcinomaBCLC BBCLC COverall survivalTumor burdenBarcelona Clinic Liver Cancer (BCLC) staging systemLiver Cancer staging systemCancer (AJCC) staging systemConventional transarterial chemoembolizationDrug-eluting beadsAllocation of patientsContrast-enhanced MRIBackground PatientsSurvival benefitRetrospective studyStaging systemC tumorsTumor volumePatientsHeterogeneous patientsMonthsChemoembolizationImpact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model
Berz AM, Santana JG, Iseke S, Gross M, Pekurovsky V, Laage Gaupp F, Savic LJ, Borde T, Gottwald LA, Boustani AM, Gebauer B, Lin M, Zhang X, Schlachter T, Madoff DC, Chapiro J. Impact of Chemoembolic Regimen on Immune Cell Recruitment and Immune Checkpoint Marker Expression following Transcatheter Arterial Chemoembolization in a VX2 Rabbit Liver Tumor Model. Journal Of Vascular And Interventional Radiology 2022, 33: 764-774.e4. PMID: 35346859, PMCID: PMC9344951, DOI: 10.1016/j.jvir.2022.03.026.Peer-Reviewed Original ResearchConceptsTranscatheter arterial chemoembolizationCytotoxic T-lymphocyte-associated protein 4Rabbit liver tumor modelConventional TACEImmune checkpoint marker expressionLiver tumor modelVX2 rabbit liver tumor modelArterial chemoembolizationBicarbonate infusionImmune responseDifferentiation 3T-lymphocyte-associated protein 4Conventional transcatheter arterial chemoembolizationTumor modelCell death protein 1Marker expressionIntratumoral T cellsImmune checkpoint markersT cell infiltrationDeath protein 1Antigen-presenting cellsImmune cell recruitmentNew Zealand white rabbitsZealand white rabbitsAPC infiltrationEstablishment of a Percutaneous Nephrostomy Service to Treat Obstructive Uropathy Secondary to Cervical Cancer in Tanzania
Rukundo I, Mbuguje E, Naif A, Patel M, Laage-Gaupp F, Asch M, Ramalingam V. Establishment of a Percutaneous Nephrostomy Service to Treat Obstructive Uropathy Secondary to Cervical Cancer in Tanzania. The Arab Journal Of Interventional Radiology 2022, 06: 033-036. DOI: 10.1055/s-0042-1744507.Peer-Reviewed Original ResearchLate-stage cervical cancerCervical cancerDays postprocedureNephrostomy placementOcean Road Cancer InstituteTechnical success rateCervical cancer mortalityMuhimbili National HospitalPercutaneous nephrostomy placementBackground Cervical cancerResource-limited countriesLate-stage cancerResearch Electronic Data CaptureResource-limited settingsQuaternary hospitalChemoradiation therapyObstructive uropathyClinical benefitDays postinterventionPercutaneous nephrostomyRetrospective studyBenefits patientsCancer mortalityNational HospitalCommon cancer
2021
Identifying enhancement-based staging markers on baseline MRI in patients with colorectal cancer liver metastases undergoing intra-arterial tumor therapy
Ghani MA, Fereydooni A, Chen E, Letzen B, Laage-Gaupp F, Nezami N, Deng Y, Gan G, Thakur V, Lin M, Papademetris X, Schernthaner RE, Huber S, Chapiro J, Hong K, Georgiades C. Identifying enhancement-based staging markers on baseline MRI in patients with colorectal cancer liver metastases undergoing intra-arterial tumor therapy. European Radiology 2021, 31: 8858-8867. PMID: 34061209, PMCID: PMC8848338, DOI: 10.1007/s00330-021-08058-7.Peer-Reviewed Original ResearchConceptsColorectal cancer liver metastasesCancer liver metastasesTotal tumor volumeIntra-arterial therapyTotal liver volumeLiver metastasesTumor volumeTumor burdenTumor diameterPatient survivalBaseline MRILiver volumeMultivariable Cox proportional hazards modelsKaplan-Meier survival curvesWhole liverCox proportional hazards modelKaplan-Meier methodPrognostic staging systemSurvival of patientsColorectal cancer metastasisMethodsThis retrospective studyPre-treatment MRIProportional hazards modelAppropriate cutoff valueHR 1.7Lipiodol as an intra-procedural imaging biomarker for liver tumor response to transarterial chemoembolization: Post-hoc analysis of a prospective clinical trial
Letzen BS, Malpani R, Miszczuk M, de Ruiter QMB, Petty CW, Rexha I, Nezami N, Laage-Gaupp F, Lin M, Schlachter TR, Chapiro J. Lipiodol as an intra-procedural imaging biomarker for liver tumor response to transarterial chemoembolization: Post-hoc analysis of a prospective clinical trial. Clinical Imaging 2021, 78: 194-200. PMID: 34022765, PMCID: PMC8364875, DOI: 10.1016/j.clinimag.2021.05.007.Peer-Reviewed Original ResearchConceptsConventional trans-arterial chemoembolizationMedian overall survivalProspective clinical trialsLipiodol depositionTumor responsePredictive biomarkersClinical trialsModified Response Evaluation CriteriaPost-TACE CTResponse Evaluation CriteriaMetastatic liver cancerKaplan-Meier analysisTrans-arterial chemoembolizationTumor response criteriaLiver tumor responsePrediction of survivalSelective drug targetingArterial embolizationLiver metastasesOverall survivalBland-Altman plotsTransarterial chemoembolizationPortal veinTumor respondersHepatocellular carcinomaRole of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma
Rexha I, Laage-Gaupp F, Chapiro J, Miszczuk MA, van Breugel JMM, Lin M, Konstantinidis M, Duran R, Gebauer B, Georgiades C, Hong K, Nezami N. Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma. Scientific Reports 2021, 11: 9337. PMID: 33927226, PMCID: PMC8085245, DOI: 10.1038/s41598-021-88426-x.Peer-Reviewed Original ResearchConceptsTotal tumor volumeConventional transarterial chemoembolizationTumor diameterIntrahepatic cholangiocarcinomaOverall survivalTumor areaICC patientsTumor volumeHigh tumor burden groupTumor analysisOS of patientsHazard ratioTransarterial chemoembolizationTumor burdenBurden groupConventional chemoembolizationHTB groupRetrospective analysisPatientsSurvival curvesMultivariate analysisChemoembolizationCholangiocarcinomaETVBaseline images
2020
Reliable prediction of survival in advanced-stage hepatocellular carcinoma treated with sorafenib: comparing 1D and 3D quantitative tumor response criteria on MRI
Doemel LA, Chapiro J, Laage Gaupp F, Savic LJ, Kucukkaya AS, Petukhova A, Tefera J, Zeevi T, Lin M, Schlachter T, Jaffe A, Strazzabosco M, Patel T, Stein SM. Reliable prediction of survival in advanced-stage hepatocellular carcinoma treated with sorafenib: comparing 1D and 3D quantitative tumor response criteria on MRI. European Radiology 2020, 31: 2737-2746. PMID: 33123796, PMCID: PMC8043967, DOI: 10.1007/s00330-020-07381-9.Peer-Reviewed Original ResearchConceptsTumor response criteriaOverall survivalAdvanced-stage HCCDisease progressionSorafenib therapyDisease controlResponse criteriaCox proportional hazards regression modelAdvanced-stage hepatocellular carcinomaProportional hazards regression modelsDCE-MRIInitiation of sorafenibTumor response analysisMultivariable Cox regressionIndependent risk factorMethodsThis retrospective analysisIndependent prognostic factorInitiation of treatmentKaplan-Meier analysisKaplan-Meier curvesHazards regression modelsLog-rank testStratification of patientsTotal tumor volumeArterial phase MRIFormation of somatosensory detour circuits mediates functional recovery following dorsal column injury
Granier C, Schwarting J, Fourli E, Laage-Gaupp F, Hennrich AA, Schmalz A, Jacobi A, Wesolowski M, Conzelmann KK, Bareyre FM. Formation of somatosensory detour circuits mediates functional recovery following dorsal column injury. Scientific Reports 2020, 10: 10953. PMID: 32616790, PMCID: PMC7331809, DOI: 10.1038/s41598-020-67866-x.Peer-Reviewed Original ResearchConceptsDetour circuitsDorsal root gangliaFunctional recoveryProprioceptive functionDorsal column-medial lemniscus pathwayUnilateral dorsal column lesionsIncomplete spinal cord injuryDorsal column injuryDorsal column lesionSpinal gray matterSpinal cord injurySpinal cord neuronsAxonal rewiringSensory fibersCord injuryColumn injuryCord neuronsRoot gangliaCuneate nucleusInitial remodelingMonosynaptic circuitSpinal networksAdult miceDRG axonsGray matterNeutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as predictors of tumor response in hepatocellular carcinoma after DEB-TACE
Schobert IT, Savic LJ, Chapiro J, Bousabarah K, Chen E, Laage-Gaupp F, Tefera J, Nezami N, Lin M, Pollak J, Schlachter T. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as predictors of tumor response in hepatocellular carcinoma after DEB-TACE. European Radiology 2020, 30: 5663-5673. PMID: 32424595, PMCID: PMC7483919, DOI: 10.1007/s00330-020-06931-5.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood PlateletsCarcinoma, HepatocellularChemoembolization, TherapeuticFemaleHumansInflammationKaplan-Meier EstimateLiver NeoplasmsLymphocytesMagnetic Resonance ImagingMaleMiddle AgedMultivariate AnalysisNeutrophilsPrognosisProgression-Free SurvivalProportional Hazards ModelsRetrospective StudiesTreatment OutcomeConceptsProgression-free survivalTreatment-naïve hepatocellular carcinomaShorter progression-free survivalPoor tumor responseDEB-TACELymphocyte ratioTumor responseHepatocellular carcinomaMagnetic resonance imagingTumor growthInflammatory biomarkersDrug-eluting bead transarterial chemoembolizationContrast-enhanced magnetic resonance imagingHigher baseline NLRHigher baseline plateletsRadiomic featuresVolumetric tumor responseLoco-regional therapyAlpha-fetoprotein levelsBead transarterial chemoembolizationKaplan-Meier analysisMethodsThis retrospective studyDifferential blood countQuantitative European AssociationNodular tumor growthBreast Imaging and Image-guided Intervention in Tanzania: Initial Experience
Okello R, Rooney T, Jumbe M, Sakafu L, Koch T, Laage-Gaupp F, Minja F, Chamberlin M. Breast Imaging and Image-guided Intervention in Tanzania: Initial Experience. Journal Of Breast Imaging 2020, 2: 269-274. PMID: 38424978, DOI: 10.1093/jbi/wbaa008.Peer-Reviewed Original ResearchBreast cancer incidenceMalignant breast diseaseRadiologic-pathologic correlationAcademic medical centerAsymptomatic womenBreast imagingSymptomatic womenBreast diseaseCancer incidenceMedical CenterCare ultrasoundLocal pathologistsHand-held pointInitial experienceWound assessmentBreast interventionsInterventionWomenUltrasound imagingImage-guided interventionsTechnologist trainingImagingUltrasound technologyPatientsBiopsyLipiodol as an Imaging Biomarker of Tumor Response After Conventional Transarterial Chemoembolization: Prospective Clinical Validation in Patients with Primary and Secondary Liver Cancer
Miszczuk MA, Chapiro J, Geschwind JH, Thakur V, Nezami N, Laage-Gaupp F, Kulon M, van Breugel JMM, Fereydooni A, Lin M, Savic LJ, Tegel B, Wahlin T, Funai E, Schlachter T. Lipiodol as an Imaging Biomarker of Tumor Response After Conventional Transarterial Chemoembolization: Prospective Clinical Validation in Patients with Primary and Secondary Liver Cancer. Translational Oncology 2020, 13: 100742. PMID: 32092672, PMCID: PMC7036424, DOI: 10.1016/j.tranon.2020.01.003.Peer-Reviewed Original ResearchMolecular Imaging of Extracellular Tumor pH to Reveal Effects of Locoregional Therapy on Liver Cancer Microenvironment
Savic LJ, Schobert I, Peters D, Walsh JJ, Laage-Gaupp F, Hamm CA, Tritz N, Doemel LA, Lin M, Sinusas A, Schlachter T, Duncan JS, Hyder F, Coman D, Chapiro J. Molecular Imaging of Extracellular Tumor pH to Reveal Effects of Locoregional Therapy on Liver Cancer Microenvironment. Clinical Cancer Research 2020, 26: 428-438. PMID: 31582517, PMCID: PMC7244230, DOI: 10.1158/1078-0432.ccr-19-1702.Peer-Reviewed Original ResearchConceptsMR spectroscopic imagingLocoregional therapyLiver cancer microenvironmentConventional transarterial chemoembolizationNew Zealand white rabbitsTumor pHMost liver tumorsZealand white rabbitsMolecular imaging paradigmsPositive therapeutic outcomesTumor residualsTransarterial chemoembolizationTumor devascularizationHistopathologic markersViable tumorSurrogate biomarkerLiver tumorsLiver cancerTumor enhancementLiver parenchymaMetabolic markersMultiparametric MRITherapeutic outcomesHIF-1αVX2 tumors