2023
T4. FINGER ON THE PULSE: INTEGRATING GENETIC AND WEARABLE DATA TO EXPLORE THE LINK BETWEEN HEART RATE VARIABILITY, ANXIETY, AND ANTIDEPRESSANTS
Friligkou E, Koller D, Pathak G, Miller E, Lampert R, Stein M, Polimanti R. T4. FINGER ON THE PULSE: INTEGRATING GENETIC AND WEARABLE DATA TO EXPLORE THE LINK BETWEEN HEART RATE VARIABILITY, ANXIETY, AND ANTIDEPRESSANTS. European Neuropsychopharmacology 2023, 75: s164. DOI: 10.1016/j.euroneuro.2023.08.294.Peer-Reviewed Original ResearchHeart rate variabilityAverage RR intervalElectronic health recordsPolygenic risk scoresReuptake inhibitorsAntidepressant classesAntidepressant useSelective serotonin reuptake inhibitorsAntidepressant substancesMendelian randomizationRate variabilityRR intervalsCo-existing health conditionsNorepinephrine reuptake inhibitorsSerotonin reuptake inhibitorsAvailable electronic health recordsBackground Anxiety disordersCardiovascular comorbiditiesAntidepressant prescriptionsOne-sample Mendelian randomizationSerotonin antagonistsTricyclic antidepressantsMajor depressionMillion Veteran ProgramObservational nature
2021
The integration of genetically-regulated transcriptomics and electronic health records highlights a pattern of medical outcomes related to increased hepatic transthyretin expression
Pathak GA, De Lillo A, Wendt FR, De Angelis F, Koller D, Mendoza B, Jacoby D, Miller EJ, Buxbaum JN, Polimanti R. The integration of genetically-regulated transcriptomics and electronic health records highlights a pattern of medical outcomes related to increased hepatic transthyretin expression. Amyloid 2021, 29: 110-119. PMID: 34935565, PMCID: PMC9213571, DOI: 10.1080/13506129.2021.2018678.Peer-Reviewed Original ResearchConceptsGenotype-Tissue Expression (GTEx) projectMulti-tissue analysisElectronic health recordsTTR amyloid formationGenetic regulationExpression projectRNA interferenceTranscriptomic profilesGene expressionExpression informationHepatic expressionHealth outcomesPhenotypic informationAmyloid formationHealth recordsCarpal tunnel syndromeTranscriptionTransthyretin expressionSystemic amyloidosesHepatic transcriptionPathological processesExpressionTunnel syndromeGastrointestinal diseasesSurgical procedures