2024
Mapping Early Brain–Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity
Pollatou A, Holland C, Stockton T, Peterson B, Scheinost D, Monk C, Spann M. Mapping Early Brain–Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity. Journal Of Neuroscience 2024, 44: e2363232024. PMID: 38604780, PMCID: PMC11140686, DOI: 10.1523/jneurosci.2363-23.2024.Peer-Reviewed Original ResearchFetal heart rate indicesDorsal anterior cingulate cortexAutonomic nervous systemDorsal anterior cingulate cortex functional connectivityFetal HRHeart rate variabilityBrain regionsFetal heart rate variationWeeks of postmenstrual ageAutonomic nervous system developmentFetal autonomic nervous systemFetal heart rate variabilityAutonomic regulationHeart rate indicesFetal heart rateNervous systemFunctional connectivityHeart rateAnterior cingulate cortex functional connectivityAnterior cingulate cortexChildren's language abilitiesFetal actocardiographInfant brainstemPostmenstrual ageWeeks gestation
2022
A functional connectome signature of blood pressure in >30 000 participants from the UK biobank.
Jiang R, Calhoun VD, Noble S, Sui J, Liang Q, Qi S, Scheinost D. A functional connectome signature of blood pressure in >30 000 participants from the UK biobank. Cardiovascular Research 2022, 119: 1427-1440. PMID: 35875865, PMCID: PMC10262183, DOI: 10.1093/cvr/cvac116.Peer-Reviewed Original ResearchConceptsBlood pressureBP levelsSystolic/diastolic blood pressurePrevalent modifiable risk factorFunctional connectivityMeaningful blood pressureDiastolic blood pressureElevated blood pressureModifiable risk factorsBody mass indexWhole-brain functional connectivityCentral autonomic networkAnterior cingulate cortexAntihypertensive medicationsMass indexMultiple confoundersPulse pressureRisk factorsCardiovascular diseaseIrreversible structural damageMedicated participantsMedication statusCingulate cortexCognitive declineAlzheimer's disease
2020
Magnetic resonance image connectivity analysis provides evidence of central nervous system mode of action for parasacral transcutaneous electro neural stimulation - A pilot study
Netto JMB, Scheinost D, Onofrey JA, Franco I. Magnetic resonance image connectivity analysis provides evidence of central nervous system mode of action for parasacral transcutaneous electro neural stimulation - A pilot study. Journal Of Pediatric Urology 2020, 16: 536-542. PMID: 32873504, DOI: 10.1016/j.jpurol.2020.08.002.Peer-Reviewed Original ResearchConceptsDorsal lateral prefrontal cortexAnterior cingulate cortexOveractive bladderFunctional connectivityPrefrontal cortexUrinary tract symptomsSacral nerve stimulatorCommon treatment modalityRight scapular regionACC functional connectivityResting-state conditionsMechanism of actionTract symptomsMotor thresholdCentral effectsACC connectivityNerve stimulatorSacral levelTreatment modalitiesFunctional connectivity dataMechanism of effectivenessAdult volunteersFrontal lobeSubcortical regionsCingulate cortex
2017
Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder
Scheinost D, Holmes SE, DellaGioia N, Schleifer C, Matuskey D, Abdallah CG, Hampson M, Krystal JH, Anticevic A, Esterlis I. Multimodal Investigation of Network Level Effects Using Intrinsic Functional Connectivity, Anatomical Covariance, and Structure-to-Function Correlations in Unmedicated Major Depressive Disorder. Neuropsychopharmacology 2017, 43: 1119-1127. PMID: 28944772, PMCID: PMC5854800, DOI: 10.1038/npp.2017.229.Peer-Reviewed Original ResearchConceptsMajor depressive disorderAnterior cingulate cortexIntrinsic functional connectivityMedial prefrontal cortexFunctional connectivityLarge-scale brain networksDepressive disorderMDD groupAnatomical covarianceBrain networksUnmedicated major depressive disorderWhole-brain intrinsic functional connectivitySystem-level disorderIntrinsic connectivity distributionRegional brain structureMultiple brain networksAltered connectivityCommon findingHealthy comparison participantsDepressive symptomsAltered volumeUnmedicated individualsLocal circuitryCingulate cortexDepressive symptomatology
2016
Neural Correlates of Success and Failure Signals During Neurofeedback Learning
Radua J, Stoica T, Scheinost D, Pittenger C, Hampson M. Neural Correlates of Success and Failure Signals During Neurofeedback Learning. Neuroscience 2016, 378: 11-21. PMID: 27063101, PMCID: PMC5537049, DOI: 10.1016/j.neuroscience.2016.04.003.Peer-Reviewed Original ResearchConceptsNeurofeedback signalFeedback learningMedial prefrontal/anterior cingulate cortexFeedback-driven learningPrecuneus/posterior cingulateClear adaptive valueDefault mode networkLevel-dependent responsesAnterior cingulate cortexOperant conditioning paradigmReduction of anxietyNeurofeedback learningNeural correlatesSignals of failureNeural processesNeurofeedback interventionConditioning paradigmNeurofeedback experimentsMode networkOrbitofrontal cortexCingulate cortexPosterior cingulateFunctional runsAbstract representationLearning
2015
Meditation leads to reduced default mode network activity beyond an active task
Garrison KA, Zeffiro TA, Scheinost D, Constable RT, Brewer JA. Meditation leads to reduced default mode network activity beyond an active task. Cognitive, Affective, & Behavioral Neuroscience 2015, 15: 712-720. PMID: 25904238, PMCID: PMC4529365, DOI: 10.3758/s13415-015-0358-3.Peer-Reviewed Original ResearchConceptsDefault mode networkDefault mode network activityBrain activation patternsDefault mode processingActive cognitive taskMode networkCognitive tasksActive tasksActivation patternsSelf-related thinkingDefault-mode activityPosterior cingulate/precuneusLong-term meditationAnterior cingulate cortexPrevious imaging studiesEffortful taskCentral neural processesNeural processesTask interactionBrain networksCingulate cortexNetwork activityMeditationReduced activation