2001
Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition
Patel A, Rothman D, Cline G, Behar K. Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition. Brain Research 2001, 919: 207-220. PMID: 11701133, DOI: 10.1016/s0006-8993(01)03015-3.Peer-Reviewed Original ResearchIn vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion
Sibson N, Mason G, Shen J, Cline G, Herskovits A, Wall J, Behar K, Rothman D, Shulman R. In vivo13C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during [2‐13C]glucose infusion. Journal Of Neurochemistry 2001, 76: 975-989. PMID: 11181817, DOI: 10.1046/j.1471-4159.2001.00074.x.Peer-Reviewed Original ResearchConceptsGlutamate/glutamine cyclingCerebral cortexAstrocytic tricarboxylic acid cycleGlutamine cyclingRat cerebral cortexGlutamine synthesisDe novo glutamine synthesisAnesthetized ratsRat brainNeurotransmitter glutamateHyperammonemic conditionsGlutamate cyclingInfusionGlutamate precursorCortexBrainTCA cycle fluxAnaplerosisMajor metabolic fluxTricarboxylic acid cycleCycle flux
1999
Energy on demand.
Magistretti P, Pellerin L, Rothman D, Shulman R. Energy on demand. Science 1999, 283: 496-7. PMID: 9988650, DOI: 10.1126/science.283.5401.496.Peer-Reviewed Original Research
1998
Functional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal Activity
Sibson N, Shen J, Mason G, Rothman D, Behar K, Shulman R. Functional Energy Metabolism:In vivo 13C-NMR Spectroscopy Evidence for Coupling of Cerebral Glucose Consumption and Gl utamatergic Neuronal Activity. Developmental Neuroscience 1998, 20: 321-330. PMID: 9778568, DOI: 10.1159/000017327.Peer-Reviewed Original ResearchConceptsRat brain cortexGlucose metabolismBrain cortexNeurotransmitter cyclingTotal glucose oxidationGlutamatergic synaptic activityCerebral glucose consumptionCerebral glucose metabolismFunctional activityFunctional imaging methodsGlucose oxidationOxidative glucose metabolismGlutamate neurotransmitter cyclingSynaptic activityNeuronal activityMild anesthesiaGlutamine synthesisMammalian brainNeurotransmitter releaseGlutamate cyclingEEG activityAmmonia metabolismNeurophysiological basisDetoxification componentsVivo resultsStoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity
Sibson N, Dhankhar A, Mason G, Rothman D, Behar K, Shulman R. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 316-321. PMID: 9419373, PMCID: PMC18211, DOI: 10.1073/pnas.95.1.316.Peer-Reviewed Original ResearchConceptsGlutamatergic neuronal activityGlutamate neurotransmitter cyclingNeuronal activityGln synthesisBrain glucose metabolismSynaptic glutamate releaseGlc metabolismGlutamate releaseRat cortexSynaptic activityGlucose metabolismNeuronal functionBrain activation studiesTricarboxylic acid cycleCortexMetabolismAcid cycleActivation studiesAstrocytesNeuronsActivity
1997
In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate–glutamine cycling
Sibson N, Dhankhar A, Mason G, Behar K, Rothman D, Shulman R. In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate–glutamine cycling. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 2699-2704. PMID: 9122259, PMCID: PMC20152, DOI: 10.1073/pnas.94.6.2699.Peer-Reviewed Original Research
1996
Enzymatic phosphorylation of muscle glycogen synthase: a mechanism for maintenance of metabolic homeostasis.
Shulman R, Rothman D. Enzymatic phosphorylation of muscle glycogen synthase: a mechanism for maintenance of metabolic homeostasis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 7491-7495. PMID: 8755501, PMCID: PMC38772, DOI: 10.1073/pnas.93.15.7491.Peer-Reviewed Original ResearchConceptsCovalent phosphorylationGlycogen synthaseGlycogen synthesisGlucose transportMuscle glycogen synthaseAllosteric activationMetabolic control analysisMetabolic homeostasisPhosphorylationGlycogenic fluxEnzymatic phosphorylationHexokinase stepGSaseMuscle cellsHomeostasisFractional activityMuscle glycogen synthesisSynthaseConcentrations of G6PG6P concentrationActivityEnzymeMechanismRoleHexokinase1H NMR Studies of Glucose Transport in the Human Brain
Gruetter R, Novotny† E, Boulware† S, Rothman* D, Shulman R. 1H NMR Studies of Glucose Transport in the Human Brain. Cerebrovascular And Brain Metabolism Reviews 1996, 16: 427-438. PMID: 8621747, DOI: 10.1097/00004647-199605000-00009.Peer-Reviewed Original Research
1995
Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR
Mason G, Gruetter R, Rothman D, Behar K, Shulman R, Novotny E. Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR. Cerebrovascular And Brain Metabolism Reviews 1995, 15: 12-25. PMID: 7798329, DOI: 10.1038/jcbfm.1995.2.Peer-Reviewed Original Research
1994
NMR studies of human brain function
Shulman R, Rothman D, Blamire A. NMR studies of human brain function. Trends In Biochemical Sciences 1994, 19: 522-526. PMID: 7846759, DOI: 10.1016/0968-0004(94)90050-7.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingPositron emission tomographyUnstimulated subjectsResonance imagingEmission tomographyBrain functionHuman brain functionSensory stimulationVisual stimulationBrain activityHuman brain activityHuman brainStimulationMetabolic rateSignificant improvementMagnetic resonance spectroscopySingle subjectSubjectsEstablished methodLocalized 13C NMR Spectroscopy in the Human Brain of Amino Acid Labeling from d‐[1‐13C]Glucose
Gruetter R, Novotny E, Boulware S, Mason G, Rothman D, Shulman G, Prichard J, Shulman R. Localized 13C NMR Spectroscopy in the Human Brain of Amino Acid Labeling from d‐[1‐13C]Glucose. Journal Of Neurochemistry 1994, 63: 1377-1385. PMID: 7931289, DOI: 10.1046/j.1471-4159.1994.63041377.x.Peer-Reviewed Original Research
1993
Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation.
Chen W, Novotny E, Zhu X, Rothman D, Shulman R. Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 9896-9900. PMID: 8234332, PMCID: PMC47679, DOI: 10.1073/pnas.90.21.9896.Peer-Reviewed Original ResearchConceptsCerebral metabolic rateGlucose levelsPhotic stimulationBrain glucose concentrationsGlucose metabolic ratePrimary visual cortexAverage maximum changeMetabolic rateVisual cortex regionsBrain glucoseCalcarine fissureVisual cortexGlucose changesLactate concentrationCortex regionsVisual stimulationStimulationGlucose concentrationHuman brainGlucose consumptionGlucose transportIndividual subjectsMinCortexLevelsNuclear magnetic resonance imaging and spectroscopy of human brain function.
Shulman R, Blamire A, Rothman D, McCarthy G. Nuclear magnetic resonance imaging and spectroscopy of human brain function. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 3127-3133. PMID: 8475050, PMCID: PMC46253, DOI: 10.1073/pnas.90.8.3127.Peer-Reviewed Original ResearchConceptsRegional cerebral blood volumeMagnetic resonance imagingMR spectroscopyResonance imagingBrain functionHuman brain functionCerebral glutamate poolPositron emission tomography studyBrain glucose concentrationsEmission tomography studiesCerebral blood volumeBlood oxygenation levelVivo magnetic resonance imagingConcentration of lactateBrain metabolismMotor cortexCerebral vasculatureSubsequent glucose metabolismBlood flowGlucose metabolismBlood volumeFrontal lobeVisual cortexBrain tissueTomography study
1992
Detection and assignment of the glucose signal in 1h nmr difference spectra of the human brain
Gruetter R, Rothman D, Novotny E, Shulman G, Prichard J, Shulman R. Detection and assignment of the glucose signal in 1h nmr difference spectra of the human brain. Magnetic Resonance In Medicine 1992, 27: 183-188. PMID: 1435204, DOI: 10.1002/mrm.1910270118.Peer-Reviewed Original ResearchNMR Determination of Intracerebral Glucose Concentration and Transport Kinetics in Rat Brain
Mason G, Behar K, Rothman D, Shulman R. NMR Determination of Intracerebral Glucose Concentration and Transport Kinetics in Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 448-455. PMID: 1569138, DOI: 10.1038/jcbfm.1992.62.Peer-Reviewed Original ResearchNMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat Brain
Mason G, Rothman D, Behar K, Shulman R. NMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat Brain. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 434-447. PMID: 1349022, DOI: 10.1038/jcbfm.1992.61.Peer-Reviewed Original Research
1991
High Resolution NMR Studies of Cerebral Glucose Metabolism in Rats and Humans
Shulman R, Rothman D, Behar K, Prichard J. High Resolution NMR Studies of Cerebral Glucose Metabolism in Rats and Humans. Advances In Experimental Medicine And Biology 1991, 291: 5-8. PMID: 1927690, DOI: 10.1007/978-1-4684-5931-9_2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1985
Application of multipulse NMR to observe 13C‐labeled metabolites in biological systems
Bendall M, Hollander J, Arias‐Mendoza F, Rothman D, Behar K, Shulman R. Application of multipulse NMR to observe 13C‐labeled metabolites in biological systems. Magnetic Resonance In Medicine 1985, 2: 56-64. PMID: 3831677, DOI: 10.1002/mrm.1910020107.Peer-Reviewed Original Research
1984
Carbon-13 nuclear magnetic resonance studies of myocardial glycogen metabolism in live guinea pigs.
Neurohr K, Gollin G, Neurohr J, Rothman D, Shulman R. Carbon-13 nuclear magnetic resonance studies of myocardial glycogen metabolism in live guinea pigs. Biochemistry 1984, 23: 5029-35. PMID: 6498174, DOI: 10.1021/bi00316a031.Peer-Reviewed Original Research