1993
Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation.
Chen W, Novotny E, Zhu X, Rothman D, Shulman R. Localized 1H NMR measurement of glucose consumption in the human brain during visual stimulation. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 9896-9900. PMID: 8234332, PMCID: PMC47679, DOI: 10.1073/pnas.90.21.9896.Peer-Reviewed Original ResearchConceptsCerebral metabolic rateGlucose levelsPhotic stimulationBrain glucose concentrationsGlucose metabolic ratePrimary visual cortexAverage maximum changeMetabolic rateVisual cortex regionsBrain glucoseCalcarine fissureVisual cortexGlucose changesLactate concentrationCortex regionsVisual stimulationStimulationGlucose concentrationHuman brainGlucose consumptionGlucose transportIndividual subjectsMinCortexLevelsNuclear magnetic resonance imaging and spectroscopy of human brain function.
Shulman R, Blamire A, Rothman D, McCarthy G. Nuclear magnetic resonance imaging and spectroscopy of human brain function. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 3127-3133. PMID: 8475050, PMCID: PMC46253, DOI: 10.1073/pnas.90.8.3127.Peer-Reviewed Original ResearchConceptsRegional cerebral blood volumeMagnetic resonance imagingMR spectroscopyResonance imagingBrain functionHuman brain functionCerebral glutamate poolPositron emission tomography studyBrain glucose concentrationsEmission tomography studiesCerebral blood volumeBlood oxygenation levelVivo magnetic resonance imagingConcentration of lactateBrain metabolismMotor cortexCerebral vasculatureSubsequent glucose metabolismBlood flowGlucose metabolismBlood volumeFrontal lobeVisual cortexBrain tissueTomography study
1991
Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation.
Prichard J, Rothman D, Novotny E, Petroff O, Kuwabara T, Avison M, Howseman A, Hanstock C, Shulman R. Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 5829-5831. PMID: 2062861, PMCID: PMC51971, DOI: 10.1073/pnas.88.13.5829.Peer-Reviewed Original Research