Deuterium imaging of the Warburg effect at sub‐millimolar concentrations by joint processing of the kinetic and spectral dimensions
Montrazi E, Bao Q, Martinho R, Peters D, Harris T, Sasson K, Agemy L, Scherz A, Frydman L. Deuterium imaging of the Warburg effect at sub‐millimolar concentrations by joint processing of the kinetic and spectral dimensions. NMR In Biomedicine 2023, 36: e4995. PMID: 37401393, DOI: 10.1002/nbm.4995.Peer-Reviewed Original ResearchTime-resolved spectroscopic imagingSub-millimolar concentrationsDeuterated substratesLow-concentration metabolitesDeuterium metabolic imagingSignal-to-noise ratioResonance positionsWarburg effectDeuteriumDetection of low-concentration metabolitesPancreatic cancer studiesSteady-state free precessionBalanced steady-state free precessionKineticsDiagnosed cancerMetabolic kineticsSignal-to-noise ratio improvementMetabolic imagingChemical shift imaging