Mitochondrial Calcium Uptake Capacity Modulates Neocortical Excitability
Sanganahalli BG, Herman P, Hyder F, Kannurpatti SS. Mitochondrial Calcium Uptake Capacity Modulates Neocortical Excitability. Cerebrovascular And Brain Metabolism Reviews 2013, 33: 1115-1126. PMID: 23591650, PMCID: PMC3705442, DOI: 10.1038/jcbfm.2013.61.Peer-Reviewed Original ResearchConceptsSensory-evoked cortical activityCentral nervous system metabolismCerebral blood flowCortical neuronal activityStimulus-evoked responsesCentral nervous systemBlood oxygen level dependenceNeocortical excitabilityBrain signalingHemodynamic responseBlood flowNeuronal activityNervous systemCortical activityNeocortical activityCalcium changesExtracellular electrophysiologyMCU activityMCU inhibitorVivo impactVivo mitochondriaDependent mannerMultiple subcellular compartmentsRole of mitochondriaUniporter activityLactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia
Herzog RI, Jiang L, Herman P, Zhao C, Sanganahalli BG, Mason GF, Hyder F, Rothman DL, Sherwin RS, Behar KL. Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. Journal Of Clinical Investigation 2013, 123: 1988-1998. PMID: 23543056, PMCID: PMC3638906, DOI: 10.1172/jci65105.Peer-Reviewed Original ResearchConceptsAntecedent recurrent hypoglycemiaRecurrent hypoglycemiaHypoglycemic conditionsIntensive insulin therapyTight glycemic controlType 2 diabetesInsulin therapyGlycemic controlBrain metabolismElevated lactateNeuronal metabolismRodent modelsNeuronal activityGlucose metabolismHypoglycemiaLactate uptakeNeuronal functionType 1Metabolic regulatorOxidative capacityModest incrementLactateMetabolismUnexpected findingBrain