2006
NMDA and non-NMDA receptors stimulation causes differential oxidative stress in rat cortical slices
Sanganahalli B, Joshi P, Joshi N. NMDA and non-NMDA receptors stimulation causes differential oxidative stress in rat cortical slices. Neurochemistry International 2006, 49: 475-480. PMID: 16860439, DOI: 10.1016/j.neuint.2006.03.006.Peer-Reviewed Original ResearchConceptsNon-NMDA receptorsAdult slicesReactive oxygen species formationNon-NMDAReactive oxygen speciesReceptor stimulationGlutamate receptorsNeuronal cell deathGlutamate-induced neuronal injuryGlutamate mediated neurotoxicityGlutamate receptor agonist NMDACell deathInflux of Ca(2+Mitochondrial depolarizationReceptor agonist NMDAFormation of reactive oxygen speciesNMDA receptor stimulationTreatment of slicesAge groupsAntagonist APVAgonist NMDAYoung slicesCortical slicesNMDA stimulationKA stimulation
2005
Xanthine oxidase, nitric oxide synthase and phospholipase A2 produce reactive oxygen species via mitochondria
Sanganahalli B, Joshi P, Joshi N. Xanthine oxidase, nitric oxide synthase and phospholipase A2 produce reactive oxygen species via mitochondria. Brain Research 2005, 1037: 200-203. PMID: 15777770, DOI: 10.1016/j.brainres.2005.01.013.Peer-Reviewed Original ResearchConceptsMitochondrial depolarizationReactive oxygen speciesReactive oxygen species formationROS formationGlutamate-induced oxidative stressOxygen speciesDepolarized mitochondriaCytoplasmic enzymeFormation of reactive oxygen speciesNitric oxide synthaseRat cortical slicesL-NAMEMitochondriaPhospholipase A(2Presence of allopurinolSpeciesEnzymeAssociated with excitotoxicityCortical slicesPLA(2PhospholipasePhospholipase A2Xanthine oxidaseSynthaseOxidative stress
2004
Glutamate-induced differential mitochondrial response in young and adult rats
Kannurpatti S, Sanganahalli B, Mishra S, Joshi P, Joshi N. Glutamate-induced differential mitochondrial response in young and adult rats. Neurochemistry International 2004, 44: 361-369. PMID: 14643754, DOI: 10.1016/s0197-0186(03)00164-5.Peer-Reviewed Original ResearchConceptsAdult ratsLDH releaseYoung ratsIntracellular calciumLactate dehydrogenaseReactive oxygen speciesExcitatory amino acid glutamateIntracellular calcium changesGlutamate-induced increaseTreatment of slicesGlutamate-induced decreaseAge groupsInfluence of glutamateMitochondrial depolarizationAmino acid glutamateMitochondrial inhibitor rotenoneCortical slicesCalcium changesReactive oxygen species formationNeuronal cell deathGlutamate stimulationGlutamate treatmentMitochondrial functionAcid glutamateCa(2+