Glutamate-induced differential mitochondrial response in young and adult rats
Kannurpatti S, Sanganahalli B, Mishra S, Joshi P, Joshi N. Glutamate-induced differential mitochondrial response in young and adult rats. Neurochemistry International 2004, 44: 361-369. PMID: 14643754, DOI: 10.1016/s0197-0186(03)00164-5.Peer-Reviewed Original ResearchConceptsAdult ratsLDH releaseYoung ratsIntracellular calciumLactate dehydrogenaseReactive oxygen speciesExcitatory amino acid glutamateIntracellular calcium changesGlutamate-induced increaseTreatment of slicesGlutamate-induced decreaseAge groupsInfluence of glutamateMitochondrial depolarizationAmino acid glutamateMitochondrial inhibitor rotenoneCortical slicesCalcium changesReactive oxygen species formationNeuronal cell deathGlutamate stimulationGlutamate treatmentMitochondrial functionAcid glutamateCa(2+