2019
Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling
Thorn SL, Barlow SC, Feher A, Stacy MR, Doviak H, Jacobs J, Zellars K, Renaud JM, Klein R, deKemp RA, Khakoo AY, Lee T, Spinale FG, Sinusas AJ. Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling. Circulation Cardiovascular Imaging 2019, 12: e009055. PMID: 31707811, PMCID: PMC7250243, DOI: 10.1161/circimaging.119.009055.Peer-Reviewed Original ResearchConceptsMyocardial blood flowSingle photon emissionBlood flowRecombinant TIMP-3Matrix metalloproteinasesR injuryTomography/Intracoronary deliveryMMP activationPost-myocardial infarction remodelingSubsequent left ventricular remodelingHybrid single-photon emissionDual-isotope single-photon emissionTomography/Computed Tomography ImagingLeft ventricular remodelingIschemia/reperfusionPost-MI remodelingPost-myocardial infarctionComputed tomography (CT) imagingIntracoronary infusionVentricular functionSaline groupVentricular remodelingNoninvasive evaluationTreatment groups
2018
New Method for Quantification of the Left Ventricular Function from Low-dose Equilibrium Radionuclide Angiocardiography: Comparisons with Conventional Methods in Patients
Liu Y, Tsatkin V, Fazzone-Chettiar R, Miller E, Sinusas A. New Method for Quantification of the Left Ventricular Function from Low-dose Equilibrium Radionuclide Angiocardiography: Comparisons with Conventional Methods in Patients. 2018, 00: 1-3. DOI: 10.1109/nssmic.2018.8824749.Peer-Reviewed Original ResearchEnd-diastolic volumeEquilibrium radionuclide angiocardiographyLeft ventricular functionGated blood pool SPECTPeak filling rateBlood pool SPECTEjection fractionVentricular functionRadionuclide angiocardiographyLV end-diastolic volumeHigh-dose injectionLow-dose injectionsAnterior oblique viewSingle photon emissionRed blood cellsDose reductionReduced radiation dosePatientsShort-axis slicesBlood cellsRadiation exposureGold standardImaging modalitiesRadiation doseOblique view
1999
Quantification of regional myocardial wall thickening on electrocardiogram-gated SPECT imaging
Shen M, Liu Y, Sinusas A, Fetterman R, Bruni W, Drozhinin O, Zaret B, Wackers F. Quantification of regional myocardial wall thickening on electrocardiogram-gated SPECT imaging. Journal Of Nuclear Cardiology 1999, 6: 583-595. PMID: 10608585, DOI: 10.1016/s1071-3581(99)90095-8.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsComputer SimulationDiastoleElectrocardiographyHeart VentriclesHumansImage Processing, Computer-AssistedModels, CardiovascularMyocardial InfarctionObserver VariationPhantoms, ImagingPilot ProjectsRadiopharmaceuticalsReproducibility of ResultsSoftwareSystoleTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonVentricular Function, LeftVentricular RemodelingVentriculography, First-PassConceptsPrior myocardial infarctionRegional wall thickeningNormal subjectsMyocardial infarctionWall thickeningNormal wall thickeningPilot studyRegional left ventricular functionLeft ventricular functionAbnormal wall thickeningPercent count increaseECG-gated SPECT imagesSingle photon emissionSPECT imagesCardiac cycleLeft ventricular wallReproducibility of interpretationRegional left ventricular wallPrior infarctionCoronary diseaseVentricular functionValidation studyInfarct areaNormal rangeAnatomic areas
1994
Effects of altered left ventricular geometry on quantitative technetium 99m sestamibi defect size in humans: Perfusion imaging during coronary angioplasty
Haronian H, Sinusas A, Remetz M, Brennan J, Cabin H, Zaret B, Wackers F. Effects of altered left ventricular geometry on quantitative technetium 99m sestamibi defect size in humans: Perfusion imaging during coronary angioplasty. Journal Of Nuclear Cardiology 1994, 1: 150-158. PMID: 9420682, DOI: 10.1007/bf02984087.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal coronary angioplastyLeft ventricular geometryAltered left ventricular geometryCoronary angioplastyRegional wall motionVentricular geometryEnd-diastolic imagesMyocardial perfusionExercise-induced myocardial ischemiaAbnormal regional wall motionMyocardial risk areaTransluminal coronary angioplastyQuantitative defectsExperimental animal modelsPlanar myocardial perfusionMyocardial perfusion imagingQuantitative technetiumResultsNine patientsVentricular functionCoronary arteryMyocardial infarctionVessel occlusionMyocardial ischemiaPerfusion defectsWall motion