2023
CT With CTA Versus MRI in Patients Presenting to the Emergency Department With Dizziness: Analysis Using Propensity Score Matching.
Tu L, Navaratnam D, Melnick E, Forman H, Venkatesh A, Malhotra A, Yaesoubi R, Sureshanand S, Sheth K, Mahajan A. CT With CTA Versus MRI in Patients Presenting to the Emergency Department With Dizziness: Analysis Using Propensity Score Matching. American Journal Of Roentgenology 2023, 221: 836-845. PMID: 37404082, DOI: 10.2214/ajr.23.29617.Peer-Reviewed Original ResearchMeSH KeywordsDizzinessEmergency Service, HospitalFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPropensity ScoreRetrospective StudiesStrokeTomography, X-Ray ComputedConceptsSecondary stroke prevention medicationsStroke prevention medicationsEmergency departmentPrevention medicationsEchocardiography evaluationPosterior circulation strokeProportion of patientsGroup of patientsPhysical examination findingsNeuroimaging resultsUse of MRIReview of systemsGreater frequencyPropensity-score matchingExamination findingsRetrospective studyED readmissionMedical historyHead CTClinical impactMRI examinationsBrain MRINeck CTADizzinessPatientsClinical criteria to exclude acute vascular pathology on CT angiogram in patients with dizziness
Tu L, Malhotra A, Venkatesh A, Taylor R, Sheth K, Yaesoubi R, Forman H, Sureshanand S, Navaratnam D. Clinical criteria to exclude acute vascular pathology on CT angiogram in patients with dizziness. PLOS ONE 2023, 18: e0280752. PMID: 36893103, PMCID: PMC9997874, DOI: 10.1371/journal.pone.0280752.Peer-Reviewed Original ResearchMeSH KeywordsAdultAngiographyCross-Sectional StudiesDizzinessEmergency Service, HospitalHumansStrokeTomography, X-Ray ComputedVertigoConceptsAcute vascular pathologyEmergency departmentVascular pathologyNegative predictive valueDizzy patientsStroke codeCTA headPredictive valueAdult ED encountersTransient ischemic attackHalf of patientsLong-term smokersLarge vessel occlusionCoronary artery diseasePast medical historySeparate validation cohortCross-sectional analysisIschemic attackAnalysis cohortArterial dissectionArtery diseaseClinical factorsED encountersMedication useChief complaint
2020
Multisystem Imaging Manifestations of COVID-19, Part 1: Viral Pathogenesis and Pulmonary and Vascular System Complications
Revzin MV, Raza S, Warshawsky R, D'Agostino C, Srivastava NC, Bader AS, Malhotra A, Patel RD, Chen K, Kyriakakos C, Pellerito JS. Multisystem Imaging Manifestations of COVID-19, Part 1: Viral Pathogenesis and Pulmonary and Vascular System Complications. RadioGraphics 2020, 40: 1574-1599. PMID: 33001783, PMCID: PMC7534458, DOI: 10.1148/rg.2020200149.Peer-Reviewed Educational MaterialsMeSH KeywordsAngiographyAngiotensin-Converting Enzyme 2BetacoronavirusCoronavirus InfectionsCOVID-19Cytokine Release SyndromeDisease ProgressionFibrin Fibrinogen Degradation ProductsHumansInflammationLungPandemicsPeptidyl-Dipeptidase APneumonia, ViralPulmonary ArteryReceptors, VirusRespiratory Distress SyndromeSARS-CoV-2Symptom AssessmentThromboembolismThrombosisThrombotic MicroangiopathiesTomography, X-Ray ComputedUltrasonographyConceptsKey imaging featuresImaging featuresCOVID-19COVID-19-associated deathsPregnancy-related manifestationsCoronavirus disease 2019Effective patient managementWorld Health OrganizationVascular complicationsClinical presentationRelated complicationsImaging manifestationsMultisystemic involvementPathologic manifestationsPatient managementImage-based reviewDisease 2019Online supplemental materialImaging hallmarksCentral vascular systemOrgan systemsRespiratory systemInfectionMusculoskeletal systemHealth OrganizationSeptic cavernous sinus thrombosis—Case series and review of the literature
Geng B, Wu X, Malhotra A. Septic cavernous sinus thrombosis—Case series and review of the literature. Clinical Neurology And Neurosurgery 2020, 197: 106092. PMID: 32693341, DOI: 10.1016/j.clineuro.2020.106092.Peer-Reviewed Original ResearchConceptsCavernous sinus thrombosisAcademic tertiary care centerSeptic cavernous sinus thrombosisExtension of thrombosisTertiary care centerInternal jugular veinTransverse-sigmoid sinusLife-threatening diseaseSource of infectionCST patientsInfectious thrombosisSinus thrombosisPatient demographicsPseudo aneurysmReported complicationsIntracranial complicationsSubdural empyemaBilateral narrowingHigh morbidityTreatment coursePersistent narrowingRadiology databaseCare centerUnilateral narrowingJugular veinUtility of routine follow-up imaging in patients with small paraflacine and/or paratentorial hemorrhages
Seifert KD, Wu X, Malhotra A. Utility of routine follow-up imaging in patients with small paraflacine and/or paratentorial hemorrhages. Clinical Neurology And Neurosurgery 2020, 196: 105956. PMID: 32526488, DOI: 10.1016/j.clineuro.2020.105956.Peer-Reviewed Original ResearchMeSH KeywordsAgedFemaleFollow-Up StudiesHumansIntracranial HemorrhagesMaleMiddle AgedNeuroimagingRetrospective StudiesTomography, X-Ray ComputedConceptsSubdural hemorrhageRoutine follow-up imagingSubsequent imagingImaging studiesSecond imaging studyAbsence of anticoagulationSubsequent imaging studiesFollow-up imagingAcute intracranial hemorrhageAnticoagulation useStable patientsRetrospective reviewClinical progressionIntracranial hemorrhageEmergency departmentClinical dataHemorrhage sizeHemorrhageRoutine imagingPatient statusPatientsParafalcineMultiple followSame protocolAverage numberDiagnostic Value of CT of Chest, Abdomen, and Pelvis in Patients With Solitary and Multiple Brain Lesions.
Rothman RK, Weinreb J, Zucconi W, Malhotra A. Diagnostic Value of CT of Chest, Abdomen, and Pelvis in Patients With Solitary and Multiple Brain Lesions. American Journal Of Roentgenology 2020, 214: 636-640. PMID: 31939701, DOI: 10.2214/ajr.19.22051.Peer-Reviewed Original ResearchConceptsPrimary neoplasmsBrain lesionsChest CTIntracranial lesionsCT CAPAncillary signsBrain neoplasmsNew intracranial lesionsPrimary brain neoplasmsMultiple brain lesionsMalignant brain neoplasmsLarge academic hospitalPresence of enhancementBrain metastasesLung primaryMetastatic workupSuch patientsPrimary cancerLesion characteristicsAcademic hospitalBenign entityCT scanPatientsMalignant casesNeoplasms
2019
A comparison of benign positional vertigo and stroke patients presenting to the emergency department with vertigo or dizziness
Hanna J, Malhotra A, Brauer PR, Luryi A, Michaelides E. A comparison of benign positional vertigo and stroke patients presenting to the emergency department with vertigo or dizziness. American Journal Of Otolaryngology 2019, 40: 102263. PMID: 31358317, DOI: 10.1016/j.amjoto.2019.07.007.Peer-Reviewed Original ResearchConceptsBenign paroxysmal positional vertigoStroke risk factorsCT/CTAEmergency departmentBPPV patientsNeurologic symptomsStroke patientsRisk factorsPositional vertigoCT headExam findingsNeurologic exam findingsPosterior circulation strokeProfile of patientsBenign positional vertigoParoxysmal positional vertigoCommon imaging modalityAcute strokeNeurologic examInitial imagingMRI brainDischarge diagnosisComputed tomographyPatientsVertigoLetter by Malhotra and Wu Regarding Article, “Computed Tomography Angiography Versus Digital Subtraction Angiography for Postclipping Aneurysm Obliteration Detection: A Meta-Analysis”
Malhotra A, Wu X. Letter by Malhotra and Wu Regarding Article, “Computed Tomography Angiography Versus Digital Subtraction Angiography for Postclipping Aneurysm Obliteration Detection: A Meta-Analysis”. Stroke 2019, 50: e158. PMID: 31104622, DOI: 10.1161/strokeaha.119.025082.Peer-Reviewed Original ResearchMeSH KeywordsAneurysmAngiography, Digital SubtractionCerebral AngiographyComputed Tomography AngiographyHumansTomography, X-Ray ComputedRe: “‘Worst Headache of Life’ in a Migraineur: Marginal Value of Emergency Department CT Scanning”
Malhotra A, Wu X, Seifert K. Re: “‘Worst Headache of Life’ in a Migraineur: Marginal Value of Emergency Department CT Scanning”. Journal Of The American College Of Radiology 2019, 16: 664-665. PMID: 31054700, DOI: 10.1016/j.jacr.2019.01.025.Peer-Reviewed Original Research
2018
Pretreatment Identification of Head and Neck Cancer Nodal Metastasis and Extranodal Extension Using Deep Learning Neural Networks
Kann BH, Aneja S, Loganadane GV, Kelly JR, Smith SM, Decker RH, Yu JB, Park HS, Yarbrough WG, Malhotra A, Burtness BA, Husain ZA. Pretreatment Identification of Head and Neck Cancer Nodal Metastasis and Extranodal Extension Using Deep Learning Neural Networks. Scientific Reports 2018, 8: 14036. PMID: 30232350, PMCID: PMC6145900, DOI: 10.1038/s41598-018-32441-y.Peer-Reviewed Original ResearchConceptsExtranodal extensionNodal metastasisPatient managementNeck cancer patient managementBlinded test setClinical decision-making toolCancer patient managementNeck cancer managementPostoperative pathologyPretreatment identificationCancer managementMetastasisRadiographic identificationCharacteristic curveCliniciansConvolutional neural networkHuman cliniciansNeural networkHeadDeep learning convolutional neural networkLymphDeep learning neural networkCost-effectiveness of Magnetic Resonance Imaging in Cervical Clearance of Obtunded Blunt Trauma After a Normal Computed Tomographic Finding
Wu X, Malhotra A, Geng B, Kalra VB, Abbed K, Forman HP, Sanelli P. Cost-effectiveness of Magnetic Resonance Imaging in Cervical Clearance of Obtunded Blunt Trauma After a Normal Computed Tomographic Finding. JAMA Surgery 2018, 153: 625-632. PMID: 29541757, PMCID: PMC5875318, DOI: 10.1001/jamasurg.2018.0099.Peer-Reviewed Original ResearchMeSH KeywordsAdultCervical VertebraeCost-Benefit AnalysisFollow-Up StudiesHumansMagnetic Resonance ImagingSpinal InjuriesTomography, X-Ray ComputedWounds, NonpenetratingConceptsMagnetic resonance imagingBlunt traumaResonance imagingCervical clearanceNeurologic deficitsTomographic findingsHealth benefitsNational Spinal Cord Injury DatabaseSpinal Cord Injury DatabaseCost of MRISpecificity of MRIUse of MRIPermanent neurologic deficitsGroup of patientsComputed tomographic findingsNegative predictive valueProbabilistic sensitivity analysesCost-effectiveness analysisLower health benefitsCervical CTCT findingsInitial CTNormal CTCervical collarCervical spineThe Patient with Thunderclap Headache
Malhotra A, Wu X, Gandhi D, Sanelli P. The Patient with Thunderclap Headache. Neuroimaging Clinics Of North America 2018, 28: 335-351. PMID: 30007749, DOI: 10.1016/j.nic.2018.03.002.Peer-Reviewed Original ResearchMeSH KeywordsAneurysm, RupturedHeadache Disorders, PrimaryHumansIntracranial AneurysmSubarachnoid HemorrhageTomography, X-Ray ComputedConceptsSubarachnoid hemorrhageThunderclap headacheCT angiographyConvexity subarachnoid hemorrhageHours of onsetPerimesencephalic subarachnoid hemorrhageNegative CT angiographyPattern of bloodCommon presentationEmergency departmentEarly diagnosisPatientsMR imagingMultiple causesHeadacheAngiographyHemorrhageBloodDiagnosisCTLetter to the Editor Regarding “Yield of Computed Tomography (CT) Angiography in Patients with Acute Headache, Normal Neurological Examination, and Normal Non Contrast CT: A Meta-Analysis”
Malhotra A, Wu X, Seifert K, Tu L. Letter to the Editor Regarding “Yield of Computed Tomography (CT) Angiography in Patients with Acute Headache, Normal Neurological Examination, and Normal Non Contrast CT: A Meta-Analysis”. Journal Of Stroke And Cerebrovascular Diseases 2018, 27: 2043. PMID: 29571755, DOI: 10.1016/j.jstrokecerebrovasdis.2018.02.049.Peer-Reviewed Original ResearchMeSH KeywordsAngiographyComputed Tomography AngiographyHeadacheHumansNeurologic ExaminationTomography, X-Ray ComputedManagement of blunt cerebrovascular injury (BCVI) in the multisystem injury patient with contraindications to immediate anti-thrombotic therapy
Malhotra A, Wu X, Tu L, Seifert K. Management of blunt cerebrovascular injury (BCVI) in the multisystem injury patient with contraindications to immediate anti-thrombotic therapy. Injury 2018, 49: 735-736. PMID: 29402423, DOI: 10.1016/j.injury.2018.01.018.Peer-Reviewed Original ResearchUtility of MRI for cervical spine clearance in blunt trauma patients after a negative CT
Malhotra A, Durand D, Wu X, Geng B, Abbed K, Nunez DB, Sanelli P. Utility of MRI for cervical spine clearance in blunt trauma patients after a negative CT. European Radiology 2018, 28: 2823-2829. PMID: 29450715, DOI: 10.1007/s00330-017-5285-y.Peer-Reviewed Original ResearchConceptsBlunt trauma evaluationCervical spine CTCervical spine MRIUnstable injuriesBlunt traumaTrauma evaluationSpine CTSpine MRIBlunt cervical spine traumaCervical spine clearanceCT cervical spineAbnormal neurological examinationBlunt trauma patientsPercent of patientsCervical spine traumaCervical spine studiesSoft tissue injuriesUtility of MRICervical CTSpine clearanceAdult patientsSubsequent MRINeurological examinationSpine traumaTrauma patients
2017
Letter to the Editor concerning “The utility of magnetic resonance imaging in addition to computed tomography scans in the evaluation of cervical spine injuries: a study of obtunded blunt trauma patients” by B.P.H. Lau, et al. [Eur Spine J (2017); doi:10.1007/s00586-017-5317-y]
Malhotra A. Letter to the Editor concerning “The utility of magnetic resonance imaging in addition to computed tomography scans in the evaluation of cervical spine injuries: a study of obtunded blunt trauma patients” by B.P.H. Lau, et al. [Eur Spine J (2017); doi:10.1007/s00586-017-5317-y]. European Spine Journal 2017, 27: 247-248. PMID: 29103129, DOI: 10.1007/s00586-017-5377-z.Peer-Reviewed Original ResearchCervical spine magnetic resonance imaging in blunt cervical trauma patients
Malhotra A, Wu X, Mahalingam S. Cervical spine magnetic resonance imaging in blunt cervical trauma patients. Journal Of Trauma And Acute Care Surgery 2017, 83: 748-749. PMID: 28930967, DOI: 10.1097/ta.0000000000001601.Peer-Reviewed Original ResearchHumansMagnetic Resonance ImagingNew EnglandProspective StudiesSpinal InjuriesTomography, X-Ray ComputedSemicircular canal dehiscence among idiopathic intracranial hypertension patients
Kuo P, Bagwell KA, Mongelluzzo G, Schutt CA, Malhotra A, Khokhar B, Kveton JF. Semicircular canal dehiscence among idiopathic intracranial hypertension patients. The Laryngoscope 2017, 128: 1196-1199. PMID: 28833207, DOI: 10.1002/lary.26795.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedFemaleHumansMaleMiddle AgedPilot ProjectsPseudotumor CerebriRetrospective StudiesSemicircular CanalsTomography, X-Ray ComputedConceptsRadiographic superior semicircular canal dehiscenceSuperior semicircular canal dehiscenceIdiopathic intracranial hypertensionSemicircular canal dehiscenceOpening pressureCanal dehiscenceIdiopathic intracranial hypertension patientsLogistic regressionIntracranial hypertension patientsBody mass indexRetrospective pilot studyMultivariate logistic regressionComputed tomography (CT) imagingStudent's t-testAverage opening pressureRetrospective cohortConsecutive patientsIntracranial hypertensionHypertension patientsMass indexRetrospective studyLumbar punctureControl cohortTegmental defectsPatientsCost-effectiveness of Magnetic Resonance Imaging in Cervical Spine Clearance of Neurologically Intact Patients With Blunt Trauma
Wu X, Malhotra A, Geng B, Liu R, Abbed K, Forman HP, Sanelli P. Cost-effectiveness of Magnetic Resonance Imaging in Cervical Spine Clearance of Neurologically Intact Patients With Blunt Trauma. Annals Of Emergency Medicine 2017, 71: 64-73. PMID: 28826754, DOI: 10.1016/j.annemergmed.2017.07.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAftercareCervical VertebraeCost-Benefit AnalysisDecision Support TechniquesHealth Care CostsHumansMagnetic Resonance ImagingMarkov ChainsModels, EconomicQuality-Adjusted Life YearsSensitivity and SpecificitySpinal InjuriesTomography, X-Ray ComputedUnited StatesWounds, NonpenetratingConceptsMagnetic resonance imagingCervical computed tomographyBlunt traumaIntact patientsUnstable injuriesCT resultsResonance imagingCost of MRICervical spine clearanceIncidence of patientsPermanent neurologic deficitsHealth benefitsNegative predictive valueProbabilistic sensitivity analysesInitial CT resultsCervical clearanceSpine clearanceNeurologic deficitsHard collarCord injuryPatient populationAlert patientsComputed tomographyPredictive valuePatientsMulticentric Chordoma
Jones JR, Huttner A, Malhotra A. Multicentric Chordoma. Clinical Neuroradiology 2017, 28: 283-288. PMID: 28766007, DOI: 10.1007/s00062-017-0610-z.Peer-Reviewed Original ResearchAgedChordomaHumansMagnetic Resonance ImagingMaleRetrospective StudiesSpinal NeoplasmsTomography, X-Ray Computed