2024
Recruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury
Ruscitti C, Abinet J, Maréchal P, Meunier M, de Meeûs C, Vanneste D, Janssen P, Dourcy M, Thiry M, Bureau F, Schneider C, Machiels B, Hidalgo A, Ginhoux F, Dewals B, Guiot J, Schleich F, Garigliany M, Bellahcène A, Radermecker C, Marichal T. Recruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury. Science Immunology 2024, 9: eado1227-eado1227. PMID: 39093958, PMCID: PMC7616420, DOI: 10.1126/sciimmunol.ado1227.Peer-Reviewed Original ResearchConceptsLung injuryAlveolar regenerationGranulocyte-macrophage colony-stimulating factorColony-stimulating factorType 2 epithelial cellsAlveolar type 2 epithelial cellsPopulation of macrophagesModels of injuryImmune cellsSuspected pneumoniaA virusAlveolar damageEpithelial regenerationInterleukin-4Lung damageMacrophage subsetsReceptor signalingLungPerilesional areaRepair responseMacrophagesTherapeutic targetInjuryCellsAirborne pathogens
2020
Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche
Roulis M, Kaklamanos A, Schernthanner M, Bielecki P, Zhao J, Kaffe E, Frommelt LS, Qu R, Knapp MS, Henriques A, Chalkidi N, Koliaraki V, Jiao J, Brewer JR, Bacher M, Blackburn HN, Zhao X, Breyer RM, Aidinis V, Jain D, Su B, Herschman HR, Kluger Y, Kollias G, Flavell RA. Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche. Nature 2020, 580: 524-529. PMID: 32322056, PMCID: PMC7490650, DOI: 10.1038/s41586-020-2166-3.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, LyArachidonic AcidCarcinogenesisCell Cycle ProteinsCell ProliferationColorectal NeoplasmsCyclooxygenase 2DinoprostoneFemaleFibroblastsHumansIntestinal MucosaIntestinesMaleMembrane ProteinsMesodermMiceNeoplastic Stem CellsOrganoidsParacrine CommunicationReceptors, Prostaglandin E, EP4 SubtypeSingle-Cell AnalysisStem Cell NicheYAP-Signaling ProteinsConceptsSingle-cell RNA-sequencing analysisTumor-initiating stem cellsRNA sequence analysisMesenchymal nicheStem cellsTumor initiationSca-1Hippo pathway effector YAPStem cell functionCell expansionPathway effector YAPMutant stem cellsEpithelial-specific ablationIntestinal stem cellsEarly tumor initiationProstaglandin E2Regenerative reprogrammingNormal epithelial stem cellsParacrine controlTumorigenic programsNiche modelsNuclear localizationTranscriptional activityYAP dephosphorylationEpithelial stem cells
2019
Increasing cerebral blood flow improves cognition into late stages in Alzheimer’s disease mice
Bracko O, Njiru B, Swallow M, Ali M, Haft-Javaherian M, Schaffer C. Increasing cerebral blood flow improves cognition into late stages in Alzheimer’s disease mice. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 1441-1452. PMID: 31495298, PMCID: PMC7308509, DOI: 10.1177/0271678x19873658.Peer-Reviewed Original ResearchConceptsShort-term memory taskAPP/PS1 miceShort-term memory functionCerebral blood flowCognitive dysfunction associated with neurodegenerative diseasesY-maze testAlzheimer's diseaseMouse model of Alzheimer's diseaseModel of Alzheimer's diseaseAPP/PS1 mouse modelAPP/PS1 mouse model of Alzheimer's diseaseMemory taskY-mazeCognitive performanceShort-term memoryMemory functionAlzheimer's disease miceGrowing body of evidenceLongitudinal Aging StudyBody of evidenceAnti-Ly6G treatmentAPP/PS1Months of ageAcute improvementGrowing body
2018
Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1.
DeLong JH, Hall AO, Konradt C, Coppock GM, Park J, Harms Pritchard G, Hunter CA. Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1. The Journal Of Immunology 2018, 200: 1761-1770. PMID: 29358280, PMCID: PMC5821564, DOI: 10.4049/jimmunol.1701154.Peer-Reviewed Original ResearchConceptsT cell expressionIL-27T cellsEffector cellsSca-1Cell expressionPathogen-specific T cellsMemory precursor effector cellsEndogenous IL-27Identification of CD8Type I IFNMemory stem cellsCytokine-mediated signalsEffector CD4Ly6C expressionSca-1 expressionImmune populationsT-betExpression of Ly6CMemory populationMouse CD4I IFNLy6CIFNMouse splenocytes
2017
The Abl‐1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education
Ganesan S, Luu TT, Chambers BJ, Meinke S, Brodin P, Vivier E, Wetzel DM, Koleske AJ, Kadri N, Höglund P. The Abl‐1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education. Scandinavian Journal Of Immunology 2017, 86: 135-142. PMID: 28605050, PMCID: PMC5568956, DOI: 10.1111/sji.12574.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, LyCell DifferentiationCells, CulturedCytotoxicity, ImmunologicImmunity, InnateInterferon-gammaKiller Cells, NaturalLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutNatural Cytotoxicity Triggering Receptor 1NK Cell Lectin-Like Receptor Subfamily CProto-Oncogene Proteins c-ablSignal TransductionConceptsNK cell educationNK cellsCell educationNatural killer cell responsivenessYAC-1 tumor cellsNK cell inhibitionNK cell functionHuman NK cellsMurine NK cellsMHC class IC-AblC-Abl expressionInhibitory Ly49Normal inhibitoryNKG2A receptorsInhibitory receptorsCell responsivenessReceptor stimulationReceptor repertoireInhibitory signalingTumor cellsITAM receptorsClass ICell inhibitionCell function
2016
The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan
Kotzin JJ, Spencer SP, McCright SJ, Kumar DBU, Collet MA, Mowel WK, Elliott EN, Uyar A, Makiya MA, Dunagin MC, Harman CCD, Virtue AT, Zhu S, Bailis W, Stein J, Hughes C, Raj A, Wherry EJ, Goff LA, Klion AD, Rinn JL, Williams A, Flavell RA, Henao-Mejia J. The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan. Nature 2016, 537: 239-243. PMID: 27525555, PMCID: PMC5161578, DOI: 10.1038/nature19346.Peer-Reviewed Original Research
2015
Lineage-related cytotoxicity and clonogenic profile of 1,4-benzoquinone-exposed hematopoietic stem and progenitor cells
Chow P, Hamid Z, Chan K, Inayat-Hussain S, Rajab N. Lineage-related cytotoxicity and clonogenic profile of 1,4-benzoquinone-exposed hematopoietic stem and progenitor cells. Toxicology And Applied Pharmacology 2015, 284: 8-15. PMID: 25645895, DOI: 10.1016/j.taap.2015.01.016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, LyApoptosisBenzoquinonesBiomarkersCD11b AntigenCell LineageCell ProliferationCells, CulturedColony-Forming Units AssayDose-Response Relationship, DrugFlow CytometryHematopoietic Stem CellsImmunophenotypingLeukocyte Common AntigensMaleMembrane ProteinsMiceMice, Inbred ICRPhenotypeStem Cell NicheConceptsHematopoietic progenitor cellsHematopoietic stem cellsColony-forming unitsSingle-lineage progenitorsBenzene exposureMouse hematopoietic progenitor cellsProgenitor cellsBenzene-induced hematotoxicityMouse BM cellsColony growthMouse bone marrow cellsBone marrow cellsBQ exposureBM cellsLymphoid populationsCellular surface antigensSurface antigenConcentration-dependent cytotoxicityBenzene metabolitesCFU-GMFlow cytometryMarrow cellsCFU-GEMMHematopoietic stemApoptotic cells
2013
Passively transferred human NMO-IgG exacerbates demyelination in mouse experimental autoimmune encephalomyelitis
Saini H, Rifkin R, Gorelik M, Huang H, Ferguson Z, Jones M, Levy M. Passively transferred human NMO-IgG exacerbates demyelination in mouse experimental autoimmune encephalomyelitis. BMC Neurology 2013, 13: 104. PMID: 23927715, PMCID: PMC3750922, DOI: 10.1186/1471-2377-13-104.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, LyAquaporin 4Demyelinating DiseasesDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalFemaleHumansImmunoglobulin GMiceMice, Inbred C57BLMyelin SheathMyelin-Oligodendrocyte GlycoproteinNeuromyelitis OpticaOptic NervePeptide FragmentsSpinal CordTime FactorsConceptsNMO-IgGCentral nervous systemSpinal cordOptic nerveAquaporin-4Long-term clinical outcomesMouse experimental autoimmune encephalomyelitisNMO-IgG biomarkerAquaporin-4 water channelsExperimental autoimmune encephalomyelitisOutcome of miceSevere neurological disabilityOnset of diseaseBackgroundNeuromyelitis opticaClinical worseningHumoral inflammationLonger-term outcomesAutoimmune encephalomyelitisFrequent exacerbationsClinical outcomesInflammatory disordersClinical examContext of EAENeurological disabilityMice
2012
Positive and Negative Signaling through SLAM Receptors Regulate Synapse Organization and Thresholds of Cytolysis
Zhao F, Cannons J, Dutta M, Griffiths G, Schwartzberg P. Positive and Negative Signaling through SLAM Receptors Regulate Synapse Organization and Thresholds of Cytolysis. Immunity 2012, 36: 1003-1016. PMID: 22683123, PMCID: PMC3389133, DOI: 10.1016/j.immuni.2012.05.017.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsAntigens, CDAntigens, LyB-LymphocytesCell AdhesionCell Line, TumorCentrosomeCytoskeletonCytotoxicity, ImmunologicFibrosarcomaImmunological SynapsesInositol Polyphosphate 5-PhosphatasesIntracellular Signaling Peptides and ProteinsLymphoma, T-CellMicePhosphoric Monoester HydrolasesPhosphorylationProtein Processing, Post-TranslationalReceptors, ImmunologicSignaling Lymphocytic Activation Molecule Associated ProteinSignaling Lymphocytic Activation Molecule Familysrc-Family KinasesT-LymphocytesT-Lymphocytes, CytotoxicConceptsSynapse organizationSAP-deficient T cellsAbsence of SAPActivation of Src kinaseT cellsB cell synapseMurine CD8(+) T cellsKilling of B cellsCD8(+) T cellsEpstein-Barr virus infectionActin clearanceAdaptor SAPX-linked lymphoproliferative syndromeT cell targetsSrc kinaseImpaired adhesionDownstream signalingNegative signalsSLAM receptorsCytotoxicity defectsCellular targetsCytotoxic lymphocytesB cellsLymphoproliferative syndromeSap
2011
Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4+ Cell Properties during Viral Infection
Marshall HD, Chandele A, Jung YW, Meng H, Poholek AC, Parish IA, Rutishauser R, Cui W, Kleinstein SH, Craft J, Kaech SM. Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4+ Cell Properties during Viral Infection. Immunity 2011, 35: 633-646. PMID: 22018471, PMCID: PMC3444169, DOI: 10.1016/j.immuni.2011.08.016.Peer-Reviewed Original ResearchConceptsAcute viral infectionViral infectionEffector cellsTfh cell markersVirus-specific effectorT helper 1Th1 effector cellsT-bet expressionIL-7R expressionMemory precursor cellsTh1 CD4Helper 1Memory TTh1 cellsProliferative responseSecondary infectionEffector typeReliable markerCell markersInfectionPrecursor cellsGene expression profilesLy6CCell featuresCell developmentMacrophages Promote Cyst Growth in Polycystic Kidney Disease
Karihaloo A, Koraishy F, Huen SC, Lee Y, Merrick D, Caplan MJ, Somlo S, Cantley LG. Macrophages Promote Cyst Growth in Polycystic Kidney Disease. Journal Of The American Society Of Nephrology 2011, 22: 1809-1814. PMID: 21921140, PMCID: PMC3187181, DOI: 10.1681/asn.2011010084.Peer-Reviewed Original ResearchConceptsPolycystic kidney diseaseCyst-lining cellsKidney diseaseCyst growthPkd1-deficient cellsContribution of inflammationMacrophage-depleted miceVehicle-treated controlsPostnatal day 10Renal functionInflammatory componentIschemic injuryOrthologous modelCre miceCystic areasLiposomal clodronateCyst progressionRenal parenchymaCystic indexTubular cellsDay 10Therapeutic potentialDay 24Macrophage migrationMacrophagesDeficient CX3CR1 Signaling Promotes Recovery after Mouse Spinal Cord Injury by Limiting the Recruitment and Activation of Ly6Clo/iNOS+ Macrophages
Donnelly DJ, Longbrake EE, Shawler TM, Kigerl KA, Lai W, Tovar CA, Ransohoff RM, Popovich PG. Deficient CX3CR1 Signaling Promotes Recovery after Mouse Spinal Cord Injury by Limiting the Recruitment and Activation of Ly6Clo/iNOS+ Macrophages. Journal Of Neuroscience 2011, 31: 9910-9922. PMID: 21734283, PMCID: PMC3139517, DOI: 10.1523/jneurosci.2114-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAntigens, LyCD11 AntigensCells, CulturedChemokine CXCL1CX3C Chemokine Receptor 1Disease Models, AnimalFlow CytometryGene Expression RegulationGreen Fluorescent ProteinsMacrophagesMiceMice, Inbred C57BLMice, TransgenicMotor ActivityMyelin Basic ProteinNitric OxideNitric Oxide Synthase Type IIReceptors, ChemokineRecovery of FunctionSignal TransductionSpinal Cord InjuriesConceptsSpinal cord injuryMonocyte-derived macrophagesCord injuryMouse spinal cord injuryTraumatic spinal cord injuryBlockade of CX3CR1Novel monocyte subsetsCX3CR1-deficient miceAnti-inflammatory therapySelective anti-inflammatory therapyWild-type miceDistinct macrophage subsetsInflammatory cytokinesMonocyte subsetsChemokine receptorsFunctional improvementSpinal cordInflammatory signalingNeurotoxic effectsPromotes recoveryMacrophage subsetsLesion siteCX3CR1Oxidative metabolitesMice
2007
PECAM-1: a multifaceted regulator of megakaryocytopoiesis
Wu Y, Welte T, Michaud M, Madri JA. PECAM-1: a multifaceted regulator of megakaryocytopoiesis. Blood 2007, 110: 851-859. PMID: 17412889, PMCID: PMC1924763, DOI: 10.1182/blood-2006-05-022087.Peer-Reviewed Original Research
2002
Ly-6 Superfamily Members Ly-6A/E, Ly-6C, and Ly-6I Recognize Two Potential Ligands Expressed by B Lymphocytes
Pflugh DL, Maher SE, Bothwell AL. Ly-6 Superfamily Members Ly-6A/E, Ly-6C, and Ly-6I Recognize Two Potential Ligands Expressed by B Lymphocytes. The Journal Of Immunology 2002, 169: 5130-5136. PMID: 12391229, DOI: 10.4049/jimmunol.169.9.5130.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, B-LymphocyteAntigens, LyB-Lymphocyte SubsetsCD59 AntigensCell Adhesion MoleculesCHO CellsCOS CellsCricetinaeGenetic VariationImmunoglobulin Constant RegionsImmunoglobulin mu-ChainsLectinsLigandsMembrane ProteinsMiceMice, Inbred C57BLMultigene FamilyMyeloid CellsProtein BindingRecombinant Fusion ProteinsSialic Acid Binding Ig-like Lectin 2TransfectionTumor Cells, CulturedConceptsLy-6 proteinsLy-6A/EChimeric proteinLy-6 moleculesMost hemopoietic cellsGlycosylphosphatidylinositol-linked proteinsMature B cellsMembrane proteinsLipid raftsLy-6ECell adhesion moleculeStages of differentiationMature B lymphocytesAnalysis of variantsIgM heavy chainSupergene familyCH27 cellsProteinHemopoietic cellsLigand activityLy-6CHeavy chainPotential ligandsB lymphocytesAdhesion molecules
2001
Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell
Krause D, Theise N, Collector M, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis S. Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell. Cell 2001, 105: 369-377. PMID: 11348593, DOI: 10.1016/s0092-8674(01)00328-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CD34Antigens, LyBone Marrow CellsCell LineageCell MovementEpithelial CellsFemaleFluorescent DyesHematopoietic Stem Cell TransplantationHematopoietic Stem CellsHumansImmunohistochemistryIn Situ Hybridization, FluorescenceIntestine, SmallKeratinsLungMaleMembrane ProteinsMiceMice, KnockoutOrganic ChemicalsPulmonary SurfactantsStem CellsY ChromosomeConceptsLong-term repopulationSingle bone marrowMulti-lineage engraftmentAdult bone marrow cellsProperties of HSCHematopoietic stemSecondary hostsGenetic diseasesStem cellsBone marrow cellsExpression increasesDifferentiative capacityBone marrowEpithelial cellsSerial transplantationRare cellsTissue repairMarrow cellsCellsDifferentiationHostSecondary recipientsGI tractPhenotypeMarrow
1990
Adoptive transfer of CD8+ T cells from immune animals does not transfer immunity to blood stage Plasmodium yoelii malaria.
Vinetz J, Kumar S, Good M, Fowlkes B, Berzofsky J, Miller L. Adoptive transfer of CD8+ T cells from immune animals does not transfer immunity to blood stage Plasmodium yoelii malaria. The Journal Of Immunology 1990, 144: 1069-74. PMID: 1967271, DOI: 10.4049/jimmunol.144.3.1069.Peer-Reviewed Original ResearchConceptsBlood-stage infectionT cellsSpleen cellsBALB/c miceBALB/c nu/nuMouse strainsClass I MHC AgMechanisms of CD8Vivo CD8 depletionAbsence of CD4Depletion of CD8P. yoelii infectionPopulation of CD4T-cell involvementAdoptive transfer experimentsPlasmodium yoelii 17XPlasmodium yoelii malariaUnfractionated spleen cellsBALB/cImmune CD4Immune CD8Vivo CD4CD8 depletionAdoptive transferImmune animalsThe CD59 antigen is a structural homologue of murine Ly‐6 antigens but lacks interferon inducibility
Philbrick W, Palfree R, Maher S, Bridgett M, Sirlin S, Bothwell A. The CD59 antigen is a structural homologue of murine Ly‐6 antigens but lacks interferon inducibility. European Journal Of Immunology 1990, 20: 87-92. PMID: 1689664, DOI: 10.1002/eji.1830200113.Peer-Reviewed Original ResearchConceptsHydrophobic carboxy terminusSomatic cell hybridsLy-6 proteinsLy-6 moleculesNeural cell typesDifferent tissue distributionInterferon inducibilityLy-6 antigensSingle geneCell hybridsLimited homologyCD59 antigenLy-6ECarboxy terminusCysteine residuesProtein sequencesCOS cellsStructural homologuesLy-6C antigenModification sitesMessage speciesLy-6Human DNAMonkey cellsCell types
1985
A comparison of lysis mediated by Lyt 2+ TNP-specific cytotoxic-T-lymphocyte (CTL) lines with that mediated by rapidly internalized lymphotoxin-containing supernatant fluids: Evidence for a role of soluble mediators in CTL-mediated killing
Schmid D, Powell M, Mahoney K, Ruddle N. A comparison of lysis mediated by Lyt 2+ TNP-specific cytotoxic-T-lymphocyte (CTL) lines with that mediated by rapidly internalized lymphotoxin-containing supernatant fluids: Evidence for a role of soluble mediators in CTL-mediated killing. Cellular Immunology 1985, 93: 68-82. PMID: 3873290, DOI: 10.1016/0008-8749(85)90389-2.Peer-Reviewed Original ResearchConceptsLyt-2Soluble mediatorsT cell-mediated lysisCytotoxic T lymphocyte lineSpecific T cell linesTarget cellsCytotoxic T lymphocytesDose-dependent fashionSupernatant fluidT cell linesSyngeneic splenocytesAppropriate target cellsT lymphocytesCytoplasm of fibroblastsLymphotoxinMild hypotonic shockLytic processLethal hitPreliminary evidenceMediatorsHypotonic shockLethal effectsCellsFibroblastsOsmotic procedure
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply