2016
The Dark Side of Cell Signaling: Positive Roles for Negative Regulators
Lemmon MA, Freed DM, Schlessinger J, Kiyatkin A. The Dark Side of Cell Signaling: Positive Roles for Negative Regulators. Cell 2016, 164: 1172-1184. PMID: 26967284, PMCID: PMC4830124, DOI: 10.1016/j.cell.2016.02.047.Peer-Reviewed Original ResearchConceptsCell signalingNegative regulatorGTP/GDP cycleNew cellular statesKinase/phosphataseCell surface receptorsCellular statesSignal terminationSwitch-like transitionsSuch regulatorsReceptor internalizationGDP cycleReceptor signalingSignal activationKinetic proofreadingSignalingRegulatorOnly negative effectNegative signalsPositive roleImportant roleNegative effectsProofreadingPhosphataseInternalization
2012
Positive and Negative Signaling through SLAM Receptors Regulate Synapse Organization and Thresholds of Cytolysis
Zhao F, Cannons J, Dutta M, Griffiths G, Schwartzberg P. Positive and Negative Signaling through SLAM Receptors Regulate Synapse Organization and Thresholds of Cytolysis. Immunity 2012, 36: 1003-1016. PMID: 22683123, PMCID: PMC3389133, DOI: 10.1016/j.immuni.2012.05.017.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsAntigens, CDAntigens, LyB-LymphocytesCell AdhesionCell Line, TumorCentrosomeCytoskeletonCytotoxicity, ImmunologicFibrosarcomaImmunological SynapsesInositol Polyphosphate 5-PhosphatasesIntracellular Signaling Peptides and ProteinsLymphoma, T-CellMicePhosphoric Monoester HydrolasesPhosphorylationProtein Processing, Post-TranslationalReceptors, ImmunologicSignaling Lymphocytic Activation Molecule Associated ProteinSignaling Lymphocytic Activation Molecule Familysrc-Family KinasesT-LymphocytesT-Lymphocytes, CytotoxicConceptsSynapse organizationSAP-deficient T cellsAbsence of SAPActivation of Src kinaseT cellsB cell synapseMurine CD8(+) T cellsKilling of B cellsCD8(+) T cellsEpstein-Barr virus infectionActin clearanceAdaptor SAPX-linked lymphoproliferative syndromeT cell targetsSrc kinaseImpaired adhesionDownstream signalingNegative signalsSLAM receptorsCytotoxicity defectsCellular targetsCytotoxic lymphocytesB cellsLymphoproliferative syndromeSap
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