2015
Lineage-related cytotoxicity and clonogenic profile of 1,4-benzoquinone-exposed hematopoietic stem and progenitor cells
Chow P, Hamid Z, Chan K, Inayat-Hussain S, Rajab N. Lineage-related cytotoxicity and clonogenic profile of 1,4-benzoquinone-exposed hematopoietic stem and progenitor cells. Toxicology And Applied Pharmacology 2015, 284: 8-15. PMID: 25645895, DOI: 10.1016/j.taap.2015.01.016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, LyApoptosisBenzoquinonesBiomarkersCD11b AntigenCell LineageCell ProliferationCells, CulturedColony-Forming Units AssayDose-Response Relationship, DrugFlow CytometryHematopoietic Stem CellsImmunophenotypingLeukocyte Common AntigensMaleMembrane ProteinsMiceMice, Inbred ICRPhenotypeStem Cell NicheConceptsHematopoietic progenitor cellsHematopoietic stem cellsColony-forming unitsSingle-lineage progenitorsBenzene exposureMouse hematopoietic progenitor cellsProgenitor cellsBenzene-induced hematotoxicityMouse BM cellsColony growthMouse bone marrow cellsBone marrow cellsBQ exposureBM cellsLymphoid populationsCellular surface antigensSurface antigenConcentration-dependent cytotoxicityBenzene metabolitesCFU-GMFlow cytometryMarrow cellsCFU-GEMMHematopoietic stemApoptotic cells
1998
Paclitaxel/carboplatin administration along with antiangiogenic therapy in non-small-cell lung and breast carcinoma models
Herbst R, Takeuchi H, Teicher B. Paclitaxel/carboplatin administration along with antiangiogenic therapy in non-small-cell lung and breast carcinoma models. Cancer Chemotherapy And Pharmacology 1998, 41: 497-504. PMID: 9554595, DOI: 10.1007/s002800050773.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic Combined Chemotherapy ProtocolsBone Marrow CellsCarboplatinCarcinoma, Lewis LungCell SurvivalColony-Forming Units AssayCyclohexanesDrug SynergismDrug Therapy, CombinationFemaleMaleMammary Neoplasms, ExperimentalMiceMice, Inbred BALB CMice, Inbred C57BLMinocyclineNeovascularization, PathologicO-(Chloroacetylcarbamoyl)fumagillolPaclitaxelSesquiterpenesConceptsTNP-470/minocyclineEMT-6 mammary carcinomaBone marrow CFU-GMLewis lung carcinomaMarrow CFU-GMEMT-6 tumor cellsLung carcinomaMammary carcinomaCFU-GMNormal tissuesTumor cellsHigh-dose paclitaxelCell lung cancerCombination of paclitaxelToxicity of carboplatinEfficacy of chemotherapyTumor growth delayBreast carcinoma modelCytotoxicity of carboplatinEarly time pointsAgent regimenAntiangiogenic regimenCarboplatin administrationLung metastasesCell lung
1997
PEG-hemoglobin: effects on tumor oxygenation and response to chemotherapy.
Teicher B, Ara G, Herbst R, Takeuchi H, Keyes S, Northey D. PEG-hemoglobin: effects on tumor oxygenation and response to chemotherapy. In Vivo 1997, 11: 301-11. PMID: 9292296.Peer-Reviewed Original ResearchConceptsPEG-hemoglobinTumor growth delayMammary carcinomaTumor cell killingSolid tumorsTumor oxygenationGrowth delayDose of chemotherapyEMT-6 murine mammary carcinomaBone marrow CFU-GMEfficacy of chemotherapyEMT-6 tumorsMurine mammary carcinomaTumor-bearing miceCFU-GM survivalMarrow CFU-GMCell killingOxygen delivery agentEMT-6 tumor-bearing miceChemotherapy administrationLung metastasesMultiple dosesSingle dosesChemotherapyCFU-GMTransforming growth factor-beta 1 overexpression produces drug resistance in vivo: reversal by decorin.
Teicher BA, Ikebe M, Ara G, Keyes SR, Herbst RS. Transforming growth factor-beta 1 overexpression produces drug resistance in vivo: reversal by decorin. In Vivo 1997, 11: 463-72. PMID: 9509296.Peer-Reviewed Original ResearchConceptsBone marrow CFU-GMMarrow CFU-GMAdministration of decorinParent tumorCFU-GMTumor linesBALB/c miceEffects of secretionsC micePlasma levelsVivo resistanceMonolayer culturesSolid tumorsTherapeutic resistanceTumorsTumor modelDrug resistanceDrug sensitivityDosage rangeThiotepaMelphalanCell linesCisplatinAdministrationAnimals
1995
Collection of mobilized blood progenitor cells for hematopoietic rescue by large‐volume leukapheresis
Comenzo R, Vosburgh E, Weintraub L, Tansan S, Arkin C, Wright D. Collection of mobilized blood progenitor cells for hematopoietic rescue by large‐volume leukapheresis. Transfusion 1995, 35: 493-497. PMID: 7770900, DOI: 10.1046/j.1537-2995.1995.35695288768.x.Peer-Reviewed Original ResearchConceptsBlood progenitor cellsDose-intensive chemotherapyRapid hematopoietic reconstitutionMononuclear cellsLarge-volume leukapheresisClonogenic progenitor cellsLVL proceduresProgenitor cellsHematopoietic rescueHematopoietic reconstitutionColony-stimulating factor administrationCFU-GMAutologous hematopoietic rescuePercent of patientsHigh-dose chemotherapyProgenitor cell collectionColony-stimulating factorLimited chemotherapyPatient weightCancer patientsFactor administrationPlatelet recoveryTarget dosesChemotherapyPatients
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