2024
Recruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury
Ruscitti C, Abinet J, Maréchal P, Meunier M, de Meeûs C, Vanneste D, Janssen P, Dourcy M, Thiry M, Bureau F, Schneider C, Machiels B, Hidalgo A, Ginhoux F, Dewals B, Guiot J, Schleich F, Garigliany M, Bellahcène A, Radermecker C, Marichal T. Recruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury. Science Immunology 2024, 9: eado1227-eado1227. PMID: 39093958, PMCID: PMC7616420, DOI: 10.1126/sciimmunol.ado1227.Peer-Reviewed Original ResearchConceptsLung injuryAlveolar regenerationGranulocyte-macrophage colony-stimulating factorColony-stimulating factorType 2 epithelial cellsAlveolar type 2 epithelial cellsPopulation of macrophagesModels of injuryImmune cellsSuspected pneumoniaA virusAlveolar damageEpithelial regenerationInterleukin-4Lung damageMacrophage subsetsReceptor signalingLungPerilesional areaRepair responseMacrophagesTherapeutic targetInjuryCellsAirborne pathogens
2014
Regulation of hepatic insulin receptor activity following injury
Jiang S, Gavrikova T, Messina J. Regulation of hepatic insulin receptor activity following injury. AJP Gastrointestinal And Liver Physiology 2014, 306: g886-g892. PMID: 24699331, PMCID: PMC4024725, DOI: 10.1152/ajpgi.00128.2013.Peer-Reviewed Original ResearchConceptsImpaired insulin receptorO-GlcNAc modificationO-GlcNAcIR tyrosine phosphorylationIR protein levelsInvolvement of JNKInhibition of JNKInsulin receptor activationIncreased serine phosphorylationTyrosine phosphorylationSer/Thr residuesPosttranslational modificationsSerine phosphorylationMembrane localizationIR activityInsulin receptorModel of insulin resistancePhosphorylationSer/ThrJNKTyrosine nitrationProtein levelsModels of injuryType 2 diabetesIR function
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