2025
Phospholipid scramblase 1: a frontline defense against viral infections
Yang A, Norbrun C, Sorkhdini P, Zhou Y. Phospholipid scramblase 1: a frontline defense against viral infections. Frontiers In Cellular And Infection Microbiology 2025, 15: 1573373. PMID: 40248364, PMCID: PMC12003403, DOI: 10.3389/fcimb.2025.1573373.Peer-Reviewed Original ResearchConceptsPhospholipid scramblase 1Human immunodeficiency virusInfluenza A virusToll-like receptor 9Human T-cell leukemia virus type 1Epstein-Barr virusHepatitis B virusInterferon-stimulated genesViral infectionHuman cytomegalovirusVirus type 1Antiviral activityTranslocation of phospholipidsFrontline defenseTransactivation of human immunodeficiency virusImmunodeficiency virusActivation of JAK/STAT pathwayImmune cellsSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2A virusB virusReceptor 9Respiratory syndrome coronavirus 2Entry of severe acute respiratory syndrome coronavirus 2
2024
SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu
Tabachnikova A, Iwasaki A. SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu. Trends In Immunology 2024, 45: 925-927. PMID: 39580310, DOI: 10.1016/j.it.2024.11.002.Peer-Reviewed Original ResearchRecruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury
Ruscitti C, Abinet J, Maréchal P, Meunier M, de Meeûs C, Vanneste D, Janssen P, Dourcy M, Thiry M, Bureau F, Schneider C, Machiels B, Hidalgo A, Ginhoux F, Dewals B, Guiot J, Schleich F, Garigliany M, Bellahcène A, Radermecker C, Marichal T. Recruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury. Science Immunology 2024, 9: eado1227-eado1227. PMID: 39093958, PMCID: PMC7616420, DOI: 10.1126/sciimmunol.ado1227.Peer-Reviewed Original ResearchConceptsLung injuryAlveolar regenerationGranulocyte-macrophage colony-stimulating factorColony-stimulating factorType 2 epithelial cellsAlveolar type 2 epithelial cellsPopulation of macrophagesModels of injuryImmune cellsSuspected pneumoniaA virusAlveolar damageEpithelial regenerationInterleukin-4Lung damageMacrophage subsetsReceptor signalingLungPerilesional areaRepair responseMacrophagesTherapeutic targetInjuryCellsAirborne pathogensIntranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract
Mao T, Kim J, Peña-Hernández M, Valle G, Moriyama M, Luyten S, Ott I, Gomez-Calvo M, Gehlhausen J, Baker E, Israelow B, Slade M, Sharma L, Liu W, Ryu C, Korde A, Lee C, Monteiro V, Lucas C, Dong H, Yang Y, Initiative Y, Gopinath S, Wilen C, Palm N, Dela Cruz C, Iwasaki A, Vogels C, Hahn A, Chen N, Breban M, Koch T, Chaguza C, Tikhonova I, Castaldi C, Mane S, De Kumar B, Ferguson D, Kerantzas N, Peaper D, Landry M, Schulz W, Grubaugh N. Intranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2319566121. PMID: 38648490, PMCID: PMC11067057, DOI: 10.1073/pnas.2319566121.Peer-Reviewed Original ResearchConceptsInterferon-stimulated genesRespiratory infectionsStrains of influenza A virusTreatment of respiratory viral infectionsRespiratory virus infectionsInfluenza A virusMouse model of COVID-19Respiratory viral infectionsNeomycin treatmentExpression of interferon-stimulated genesUpper respiratory infectionInterferon-stimulated gene expressionLower respiratory infectionsBroad spectrum of diseasesAdministration of neomycinRespiratory viral diseasesDisease to patientsUpper respiratory tractIntranasal deliveryCongenic miceIntranasal applicationNasal mucosaSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2A virusGenome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB–dependent IFITM3 expression
Munir M, Embry A, Doench J, Heaton N, Wilen C, Orchard R. Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB–dependent IFITM3 expression. Journal Of Biological Chemistry 2024, 300: 107153. PMID: 38462163, PMCID: PMC11001640, DOI: 10.1016/j.jbc.2024.107153.Peer-Reviewed Original ResearchInterferon-induced transmembrane protein 3Influenza A Virus InfectionCRISPR activation screenGenome-wide CRISPR activation screenIFITM3 expressionResistant to influenza A virus infectionHBO1 complexRegulate transcriptionModify chromatinNF-kB signaling pathwayNF-kBInnate immune systemInfluenza A virusAntiviral genesInteraction pathwaySignaling pathwayInduced expressionActivity screeningImmune landscapeA virusProtein 3Novel nodesExpressionImmune systemInfluenza
2022
Fulminant Viral Hepatitis in Two Siblings with Inherited IL-10RB Deficiency
Korol C, Belkaya S, Alsohime F, Lorenzo L, Boisson-Dupuis S, Brancale J, Neehus A, Vilarinho S, Zobaida A, Halwani R, Al-Muhsen S, Casanova J, Jouanguy E. Fulminant Viral Hepatitis in Two Siblings with Inherited IL-10RB Deficiency. Journal Of Clinical Immunology 2022, 43: 406-420. PMID: 36308662, PMCID: PMC9892130, DOI: 10.1007/s10875-022-01376-5.Peer-Reviewed Original ResearchConceptsEarly onset inflammatory bowel diseaseFulminant viral hepatitisHepatitis A virusIL-10IL-22IL-26Viral hepatitisIFN-λ1Inflammatory bowel diseaseIFN-γ productionIFN-γ activityLife-threatening diseaseImpairs cellular responsesHAV infectionBowel diseaseLymphocyte cytotoxicityIL-18BPIFN-λsDisease-causing variantsHealthy individualsPatientsA virusCellular responsesUnrelated patientsPotent antagonistGenetic Evolution of Avian Influenza A (H9N2) Viruses Isolated from Domestic Poultry in Uganda Reveals Evidence of Mammalian Host Adaptation, Increased Virulence and Reduced Sensitivity to Baloxavir
Atim G, Tugume T, Ukuli Q, Erima B, Mubiru A, Kibuuka H, Mworozi E, McKenzie P, Turner J, Walker D, Jeevan T, Webster R, Jones J, Webby R, Ducatez M, Wabwire-Mangen F, Byarugaba D. Genetic Evolution of Avian Influenza A (H9N2) Viruses Isolated from Domestic Poultry in Uganda Reveals Evidence of Mammalian Host Adaptation, Increased Virulence and Reduced Sensitivity to Baloxavir. Viruses 2022, 14: 2074. PMID: 36146881, PMCID: PMC9505320, DOI: 10.3390/v14092074.Peer-Reviewed Original ResearchConceptsMammalian host adaptationHost adaptationInfluenza A virusLive bird marketsEvolution of H9N2 virusesGenetic evolution of H9N2 virusesH9N2 virusesGenetic evolutionIllumina MiSeq platformSequencing data analysisA virusGenome sequenceBird marketsAvian influenza A virusesNucleotide substitutionsMiSeq platformPromote drug resistancePoor biosecurity practicesIncreased virulenceContemporary isolatesH9N2 isolatesAvian influenza ACloacal samplesAnti-influenza drugsBaloxavir acidThe Species-Specific 282 Residue in the PB2 Subunit of the Polymerase Regulates RNA Synthesis and Replication of Influenza A Viruses Infecting Bat and Nonbat Hosts
Banerjee S, De A, Kedia N, Bhakta K, Wang L, Bhattacharjee B, Mondal A. The Species-Specific 282 Residue in the PB2 Subunit of the Polymerase Regulates RNA Synthesis and Replication of Influenza A Viruses Infecting Bat and Nonbat Hosts. Journal Of Virology 2022, 96: e02190-21. PMID: 35044213, PMCID: PMC8906409, DOI: 10.1128/jvi.02190-21.Peer-Reviewed Original ResearchConceptsBat influenza virusesInfluenza virus polymeraseInfluenza A virusVirus polymerasePB2 subunitIAV RNA polymeraseGenera of influenza virusesHost speciesAdaptation of influenza virusesInfluenza virusHuman cellsPolymerase subunit PB2RNA synthesis activitySpecies-specific signaturesHuman-specific signaturesAmino acid preferencesReduced polymerase activityAmino acid alterationsGlutamic acidA virusSurface antigen hemagglutininCross-species transmissionRNA polymerasePB2 proteinSignature residues
2021
Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes
Mandal P, Bhattacharjee B, Sen S, Bhattacharya A, Saha S, Chowdhury R, Mondal N, Chakrabarty B, Chatterjee T, Roy S, Sengupta S. Predominance of genomically defined A lineage of HPV16 over D lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in association with distinct oncogenic phenotypes. Translational Oncology 2021, 15: 101256. PMID: 34717279, PMCID: PMC8564679, DOI: 10.1016/j.tranon.2021.101256.Peer-Reviewed Original ResearchSquamous cell carcinomaSquamous cell carcinoma casesLineage ACell carcinomaCervical squamous cell carcinomaE7 mRNA expressionHuman papillomavirus type 16Lineage A virusNon-malignant specimensAssociation of variantsDNA copy numberD lineageCytological outcomeHPV16 genomeEpisomal HPV16Sub-lineagesCopy numberIndian patientsA virusType 16Oncogenic phenotypeHPV16LineagesA1 virusesRisk allelesInfluenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses
Mytle N, Leyrer S, Inglefield JR, Harris AM, Hickey TE, Minang J, Lu H, Ma Z, Andersen H, Grubaugh ND, Guina T, Skiadopoulos MH, Lacy MJ. Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses. Viruses 2021, 13: 1708. PMID: 34578289, PMCID: PMC8473317, DOI: 10.3390/v13091708.Peer-Reviewed Original ResearchConceptsBALB/c miceC miceAntigens of influenzaSeasonal influenza vaccineInfluenza virus antigensSerum antibody responseVaccinia virus AnkaraMajor protective antigenMatrix protein 2Influenza A virusesViral burdenInfluenza vaccineAnnual immunizationProtective immunityLethal challengeAntibody responseVirus antigenVirus AnkaraNatural immunityAntigen hemagglutininM2e antigenAntigenic driftA virusAntigenProtective antigen
2018
An Infant Mouse Model of Influenza Virus Transmission Demonstrates the Role of Virus-Specific Shedding, Humoral Immunity, and Sialidase Expression by Colonizing Streptococcus pneumoniae
Ortigoza M, Blaser S, Zafar M, Hammond A, Weiser J. An Infant Mouse Model of Influenza Virus Transmission Demonstrates the Role of Virus-Specific Shedding, Humoral Immunity, and Sialidase Expression by Colonizing Streptococcus pneumoniae. MBio 2018, 9: 10.1128/mbio.02359-18. PMID: 30563897, PMCID: PMC6299224, DOI: 10.1128/mbio.02359-18.Peer-Reviewed Original ResearchConceptsInfluenza A virusSusceptible to influenza A virusesInfluenza A virus transmissionInfant mouse modelUpper respiratory tractInfluenza A virus sheddingHumoral immunityMouse modelInfluenza A virus strainsTransmission of influenza A virusesAnimal modelsVirus strainsInfluenza virus strainsUpper respiratory tract floraGuinea pig modelAntagonizing transmissionAdult miceSusceptible recipientsA virusMarker of infectiousnessSialidase expressionPandemic potentialViral sheddingRespiratory tractPig model
2016
Clinical Features and Transmission Pattern of Hepatitis A: An Experience from a Hepatitis A Outbreak Caused by Two Cocirculating Genotypes in Sri Lanka.
Dahanayaka NJ, Kiyohara T, Agampodi SB, Samaraweera PK, Kulasooriya GK, Ranasinghe JC, Semage SN, Yoshizaki S, Wakita T, Ishii K. Clinical Features and Transmission Pattern of Hepatitis A: An Experience from a Hepatitis A Outbreak Caused by Two Cocirculating Genotypes in Sri Lanka. American Journal Of Tropical Medicine And Hygiene 2016, 95: 908-914. PMID: 27382079, PMCID: PMC5062799, DOI: 10.4269/ajtmh.16-0221.Peer-Reviewed Original ResearchConceptsHepatitis A virusMost patientsHepatitis AHAV immunoglobulin MIntermediate endemic areaAcute viral hepatitisUpper abdominal discomfortHepatitis A outbreaksHigh-risk groupStrains of HAVMilitary personnelAcute hepatitisHAV vaccinationPale stoolsAbdominal discomfortViral hepatitisClinical featuresHepatitis outbreakSubgenotype IAClinical informationInfected personsPatientsA virusHepatitisSerial outbreaks
2013
Seroprevalence of Hepatitis A among Students Enrolled in Tehran University of Medical Sciences during 2011.
Rabiee A, Nikayin S, Hashemi SR, Mohaghegh M, Amini M, Rabiee R, Merat S. Seroprevalence of Hepatitis A among Students Enrolled in Tehran University of Medical Sciences during 2011. Middle East Journal Of Digestive Diseases 2013, 5: 137-40. PMID: 24829683, PMCID: PMC3990182.Peer-Reviewed Original ResearchHepatitis A virusHepatitis ATehran UniversitySeroprevalence of HAVAnti-HAV IgG antibodiesAnti-HAV antibodiesHealth science studentsHigh-risk groupUniversal vaccination strategyMedical SciencesIgG antibodiesVaccination strategiesRisk groupsHealth workersTargeted vaccinationHigh riskGeneral populationSeropositive resultsA virusSimple questionnaireSerum samplesSeroprevalenceVaccinationSerious diseasePrevious reports
2010
Household Transmission of 2009 Influenza A (H1N1) Virus after a School-Based Outbreak in New York City, April–May 2009
France AM, Jackson M, Schrag S, Lynch M, Zimmerman C, Biggerstaff M, Hadler J. Household Transmission of 2009 Influenza A (H1N1) Virus after a School-Based Outbreak in New York City, April–May 2009. The Journal Of Infectious Diseases 2010, 201: 984-992. PMID: 20187740, DOI: 10.1086/651145.Peer-Reviewed Original ResearchConceptsInfluenza-like illnessIndex case patientsInfluenza A virusesHousehold contactsCase patientsHousehold transmissionRisk of ILIPandemic influenza A (H1N1) virusA virusDays of onsetPercent of casesYears of ageExtent of transmissionAntiviral prophylaxisPH1N1 transmissionRisk factorsAdditional protective factorsHigh riskMultivariate analysisOlder ageProtective factorsIllnessIll studentsPatientsContact group
2008
Structural basis for the function and inhibition of an influenza virus proton channel
Stouffer A, Acharya R, Salom D, Levine A, Di Costanzo L, Soto C, Tereshko V, Nanda V, Stayrook S, DeGrado W. Structural basis for the function and inhibition of an influenza virus proton channel. Nature 2008, 451: 596-599. PMID: 18235504, PMCID: PMC3889492, DOI: 10.1038/nature06528.Peer-Reviewed Original Research
2003
Comparison of SmartCycler Real-Time Reverse Transcription-PCR Assay in a Public Health Laboratory with Direct Immunofluorescence and Cell Culture Assays in a Medical Center for Detection of Influenza A Virus
Habib-Bein NF, Beckwith WH, Mayo D, Landry ML. Comparison of SmartCycler Real-Time Reverse Transcription-PCR Assay in a Public Health Laboratory with Direct Immunofluorescence and Cell Culture Assays in a Medical Center for Detection of Influenza A Virus. Journal Of Clinical Microbiology 2003, 41: 3597-3601. PMID: 12904361, PMCID: PMC179819, DOI: 10.1128/jcm.41.8.3597-3601.2003.Peer-Reviewed Original ResearchConceptsVirus-positive specimensDirect immunofluorescence antibody stainingPublic health laboratoriesHealth laboratoriesRT-PCRMedical CenterRapid diagnosisYale-New Haven HospitalReal-time RT-PCRResults of cultureRhesus monkey kidney cell culturesImmunofluorescence antibody stainingReal-time reverse transcriptionInfluenza A virusesMonkey kidney cell culturesConventional RT-PCR analysisReal-time RT-PCR systemRespiratory specimensInfluenza APatient managementDirect immunofluorescenceCell culturesKidney cell culturesRapid turnaround timeA virus
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