2022
Post-liver transplantation bile leaks and strictures
Muniraj T. Post-liver transplantation bile leaks and strictures. Gastrointestinal Endoscopy 2022, 95: 1233-1237. PMID: 35124073, DOI: 10.1016/j.gie.2022.01.021.Peer-Reviewed Original Research
2021
Cholecystectomy Is Superior to Medical Management for Biliary Pain in Pediatric Patients
Shah P, Saluja S, Cowles R. Cholecystectomy Is Superior to Medical Management for Biliary Pain in Pediatric Patients. Journal Of Gastrointestinal Surgery 2021, 25: 2435-2436. PMID: 34255291, DOI: 10.1007/s11605-021-05083-1.Peer-Reviewed Original Research
2019
Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases
Fabris L, Fiorotto R, Spirli C, Cadamuro M, Mariotti V, Perugorria MJ, Banales JM, Strazzabosco M. Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases. Nature Reviews Gastroenterology & Hepatology 2019, 16: 497-511. PMID: 31165788, PMCID: PMC6661007, DOI: 10.1038/s41575-019-0156-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCystic fibrosis-related liver diseaseFibropolycystic liver diseaseLiver diseasePolycystic liver diseaseBiliary repairAlagille syndromeEpithelial toll-like receptor 4Toll-like receptor 4Acquired liver diseasesGut-derived productsPrimary sclerosing cholangitisDuct epithelial cellsSclerosing cholangitisΒ-catenin signalingPortal fibrosisBiliary diseaseIL-1βUnknown etiologyDependent cytokinesReceptor 4Peribiliary inflammationRole of NotchCholangiopathyNovel treatmentsCyst growthCholangiocyte pathobiology
Banales JM, Huebert RC, Karlsen T, Strazzabosco M, LaRusso NF, Gores GJ. Cholangiocyte pathobiology. Nature Reviews Gastroenterology & Hepatology 2019, 16: 269-281. PMID: 30850822, PMCID: PMC6563606, DOI: 10.1038/s41575-019-0125-y.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityBile Duct DiseasesBile DuctsEpithelial CellsFibrosisHumansImmunity, InnateInflammationLiver FailureLiver RegenerationConceptsCholangiocyte pathobiologyNew disease-modifying therapiesLiver regenerationRole of cholangiocytesAdvanced liver failureDisease-modifying therapiesExtrahepatic bile ductChronic disease statesAdaptive immune responsesReactive ductular cellsLiver failureBiliary tractLiver diseaseBile ductBile productionImmune responseHepatocyte regenerationImmune systemDuctular cellsCholangiopathyDisease statesCholangiocytesEpithelial cellsAnatomic nicheRepair response
2018
Fibroinflammatory Liver Injuries as Preneoplastic Condition in Cholangiopathies
Cannito S, Milani C, Cappon A, Parola M, Strazzabosco M, Cadamuro M. Fibroinflammatory Liver Injuries as Preneoplastic Condition in Cholangiopathies. International Journal Of Molecular Sciences 2018, 19: 3875. PMID: 30518128, PMCID: PMC6321547, DOI: 10.3390/ijms19123875.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBile Duct DiseasesEpitheliumHumansLiverLiver CirrhosisMesodermPrecancerous ConditionsConceptsMain molecular mechanismsDifferent lineagesPrimary sclerosing cholangitisMolecular mechanismsProfibrotic chemokinesNeoplastic transformationSclerosing cholangitisCaroli's diseaseOrgan dysfunctionChronic cholangiopathiesInflammatory infiltrateLiver injuryPeriportal fibrosisLiver diseaseInflammatory cellsProinflammatory cytokinesBiliary treePreneoplastic conditionsDifferent etiologiesTumor developmentMurine modelLiver responseParacrine fashionHepatic responseCellular types
2017
Animal models of biliary injury and altered bile acid metabolism
Mariotti V, Strazzabosco M, Fabris L, Calvisi DF. Animal models of biliary injury and altered bile acid metabolism. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2017, 1864: 1254-1261. PMID: 28709963, PMCID: PMC5764833, DOI: 10.1016/j.bbadis.2017.06.027.Peer-Reviewed Original ResearchConceptsBile acid metabolismBiliary injuryMouse modelAnimal modelsDistinct immune systemCholestatic liver injuryAcid metabolismJesus BanalesMarco MarzioniNicholas LaRussoPeter JansenBiliary repairLiver injuryDuctular reactionLiver repairObstructive cholestasisDisease progressionPeribiliary inflammationMain phenotypic featuresBiliary dysgenesisViral infectionImmune systemLiver homeostasisLiver phenotypeHuman settingEmerging concepts in biliary repair and fibrosis
Fabris L, Spirli C, Cadamuro M, Fiorotto R, Strazzabosco M. Emerging concepts in biliary repair and fibrosis. AJP Gastrointestinal And Liver Physiology 2017, 313: g102-g116. PMID: 28526690, PMCID: PMC5582882, DOI: 10.1152/ajpgi.00452.2016.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsReactive ductular cellsBiliary repairBiliary treeDuctular cellsProliferation of cholangiocytesCongenital hepatic fibrosisBiliary fibrosisInflammatory changesBiliary atresiaChronic cholangiopathiesClinical progressionClinical hepatologyHepatic fibrosisLiver repairMajor unmetBiliary epitheliumChronic diseasesChronic damageReparative responseAlagille syndromeLiver pathophysiologyReparative processesFibrosisPathological repairCellular elementsVanishing bile duct syndrome in Hodgkin’s lymphoma: A case report and literature review
Bakhit M, McCarty TR, Park S, Njei B, Cho M, Karagozian R, Liapakis A. Vanishing bile duct syndrome in Hodgkin’s lymphoma: A case report and literature review. World Journal Of Gastroenterology 2017, 23: 366-372. PMID: 28127210, PMCID: PMC5236516, DOI: 10.3748/wjg.v23.i2.366.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntineoplastic AgentsBile Duct DiseasesBile Ducts, IntrahepaticBiopsyCholangiopancreatography, Magnetic ResonanceCholestasisExomeHepatocyte Growth FactorHigh-Throughput Nucleotide SequencingHodgkin DiseaseHumansHyperbilirubinemiaHypertension, PortalJaundiceLiverLiver Function TestsMaleNeoplasm StagingProto-Oncogene ProteinsSyndromeTomography, X-Ray ComputedConceptsBile duct syndromeHodgkin's lymphomaIntra-hepatic bile ductsBile duct lossBile duct injuryAdverse drug reactionsDifferent pathologic conditionsTransplant evaluationDuct injuryAllograft rejectionClinical recoveryParaneoplastic phenomenonBiliary cirrhosisLiver biopsyLiver failureBile ductAutoimmune diseasesCase reportDrug reactionsEarly recognitionPhysical examPoor responseVBDSHumoral factorsMedical treatment
2016
A retrospective comparison of robotic cholecystectomy versus laparoscopic cholecystectomy: operative outcomes and cost analysis
Strosberg DS, Nguyen MC, Muscarella P, Narula VK. A retrospective comparison of robotic cholecystectomy versus laparoscopic cholecystectomy: operative outcomes and cost analysis. Surgical Endoscopy 2016, 31: 1436-1441. PMID: 27495346, DOI: 10.1007/s00464-016-5134-0.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBile Duct DiseasesCholangiographyCholangitisCholecystectomy, LaparoscopicCholecystitisCholedocholithiasisCholelithiasisChronic DiseaseConversion to Open SurgeryCosts and Cost AnalysisFemaleGallbladder DiseasesHumansMaleMiddle AgedOperative TimePostoperative ComplicationsRetrospective StudiesRobotic Surgical ProceduresTreatment OutcomeYoung AdultConceptsLaparoscopic cholecystectomyRobotic cholecystectomyIntraoperative cholangiographyOperative outcomesHigher Body Mass IndexBile leak rateBile duct injuryCoronary artery diseaseLarge academic medical centerLonger operative timeBody mass indexAcademic medical centerHigher total chargesLower ratesHealth care systemDuct injuryPostoperative complicationsPerioperative variablesArtery diseaseChronic cholecystitisOperative timeRetrospective reviewSingle surgeonMass indexPatient groupIncidence of hepaticojejunostomy stricture after hepaticojejunostomy
Dimou FM, Adhikari D, Mehta HB, Olino K, Riall TS, Brown KM. Incidence of hepaticojejunostomy stricture after hepaticojejunostomy. Surgery 2016, 160: 691-698. PMID: 27392391, PMCID: PMC5429863, DOI: 10.1016/j.surg.2016.05.021.Peer-Reviewed Original ResearchConceptsBiliary-enteric anastomosisStricture formationBiliary-enteric anastomotic stricturesCox proportional hazards modelManagement of stricturesProportional hazards modelCumulative incidence curvesMedicare claims dataUse of imagingStricture diagnosisCumulative incidenceAnastomotic strictureHepaticojejunostomy stricturesPostoperative strictureTrue incidenceClaims dataHazards modelPatientsStrictureAnastomosisDecreased likelihoodYounger ageIncidence curvesIncidenceMean time
2013
Vascular biology of the biliary epithelium
Morell CM, Fabris L, Strazzabosco M. Vascular biology of the biliary epithelium. Journal Of Gastroenterology And Hepatology 2013, 28: 26-32. PMID: 23855292, PMCID: PMC3721432, DOI: 10.1111/jgh.12022.Peer-Reviewed Original ResearchMeSH KeywordsAngiopoietinsAnimalsAutocrine CommunicationBile Duct DiseasesBile Ducts, IntrahepaticEpithelial CellsEpitheliumHumansLiverLiver Diseases, AlcoholicLiver RegenerationNeovascularization, PathologicParacrine CommunicationPlatelet-Derived Growth FactorRatsSignal TransductionVascular Endothelial Growth Factor AConceptsBile ductIntrahepatic bile ductsHepatic arteryPeribiliary plexusUnderlying molecular mechanismsArterial supplyLiver repairNormal organ physiologyLiver pathophysiologyVascular cell typesPathophysiological settingsVascular structuresStrong associationVascular biologyDifferent vascular cell typesCholangiocytesAngiogenic signalsLiver developmentCell typesMolecular mechanismsOrgan physiologyDuctAssociationCross talk
2012
Interpretation of Probe-Based Confocal Laser Endomicroscopy of Indeterminate Biliary Strictures: Is There Any Interobserver Agreement?
Talreja JP, Sethi A, Jamidar PA, Singh SK, Kwon RS, Siddiqui UD, Sawhney M, Bakhru MR, Gaidhane M, Kline P, Sauer BG, Kahaleh M. Interpretation of Probe-Based Confocal Laser Endomicroscopy of Indeterminate Biliary Strictures: Is There Any Interobserver Agreement? Digestive Diseases And Sciences 2012, 57: 3299-3302. PMID: 22875310, DOI: 10.1007/s10620-012-2338-6.Peer-Reviewed Original ResearchDevelopment of the bile ducts: Essentials for the clinical hepatologist
Strazzabosco M, Fabris L. Development of the bile ducts: Essentials for the clinical hepatologist. Journal Of Hepatology 2012, 56: 1159-1170. PMID: 22245898, PMCID: PMC3328609, DOI: 10.1016/j.jhep.2011.09.022.Peer-Reviewed Original ResearchConceptsLiver diseaseBile ductBiliary structuresFibropolycystic liver diseaseExtrahepatic biliary treeBiliary developmentLiver repair mechanismsHepatocellular damageBiliary treeDuctular reactionLiver repairReparative responseAlagille syndromePathogenic aspectsClinical hepatologistsCholangiopathyGrowth factorParacrine signalsEmbryonic lifeDiseaseDuctRepair mechanismsHepatologistsSyndromeTranscription factors
2007
Mycophenolate mofetil for drug-induced vanishing bile duct syndrome.
Jakab SS, West AB, Meighan DM, Brown RS, Hale WB. Mycophenolate mofetil for drug-induced vanishing bile duct syndrome. World Journal Of Gastroenterology 2007, 13: 6087-9. PMID: 18023105, PMCID: PMC4250896, DOI: 10.3748/wjg.v13.45.6087.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmoxicillin-Potassium Clavulanate CombinationAnti-Bacterial AgentsBile Duct DiseasesHumansImmunosuppressive AgentsMaleMycophenolic AcidConceptsBile duct syndromeAmoxicillin/clavulanateMycophenolate mofetilLow-dose mycophenolate mofetilSequential liver biopsiesInosine monophosphate dehydrogenase inhibitorSustained remissionCholestatic patternImmunosuppressive therapyElderly patientsProlonged cholestasisLiver biopsyLiver injuryMofetilPatientsComplete withdrawalAzathioprineSyndromeClavulanateDehydrogenase inhibitorCirrhosisCorticosteroidsPrednisoneRemissionCholestasis
2000
Characterization and Isolation of Ductular Cells Coexpressing Neural Cell Adhesion Molecule and Bcl-2 from Primary Cholangiopathies and Ductal Plate Malformations
Fabris L, Strazzabosco M, Crosby H, Ballardini G, Hubscher S, Kelly D, Neuberger J, Strain A, Joplin R. Characterization and Isolation of Ductular Cells Coexpressing Neural Cell Adhesion Molecule and Bcl-2 from Primary Cholangiopathies and Ductal Plate Malformations. American Journal Of Pathology 2000, 156: 1599-1612. PMID: 10793072, PMCID: PMC1876925, DOI: 10.1016/s0002-9440(10)65032-8.Peer-Reviewed Original ResearchConceptsDuctal plate malformationNeural cell adhesion moleculeReactive ductulesDuctular cellsLiver diseaseKi-67Cell adhesion moleculeDuctal plateChronic cholestatic liver diseaseDifferent chronic liver diseasesAdhesion moleculesReactive bile ductulesProliferation marker Ki-67Chronic liver diseaseCholestatic liver diseaseDuctal plate cellsBcl-2Different gestational agesDuctular reactive cellsGestational ageLKM-1Neuroendocrine featuresHEA 125Cirrhotic liverImmunohistochemical expressionPathophysiology of the intrahepatic biliary epithelium
Strazzabosco M, Spirlì C, Okolicsanyi L. Pathophysiology of the intrahepatic biliary epithelium. Journal Of Gastroenterology And Hepatology 2000, 15: 244-253. PMID: 10764023, DOI: 10.1046/j.1440-1746.2000.02091.x.Peer-Reviewed Original ResearchConceptsIntrahepatic biliary epitheliumBiliary epitheliumIntrahepatic bile duct epitheliumChronic cholestatic disorderBile duct epitheliumCholangiocyte functionBasic disease mechanismsPortal inflammationBiliary atresiaGastrointestinal hormonesCholestatic disordersPathophysiological pointBiliary treeCholangiocyte pathophysiologyImmune regulationPharmacological approachesNormal epitheliumCholangiocyte proliferationCholangiopathyDuct epitheliumInfectious agentsImportant causeBile acidsCystic fibrosisImmunoglobulin A.
1991
Partial hepatectomy for Caroli's syndrome. Report of two patients with long-term follow-up.
Orozco H, Takahashi T, Garcia-Tsao G, Mercado M, Quiroz F, Hernandez-Cendejas A. Partial hepatectomy for Caroli's syndrome. Report of two patients with long-term follow-up. Hepatogastroenterology 1991, 38: 33-5. PMID: 2026386.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBile Duct DiseasesBile Ducts, IntrahepaticCystsDilatation, PathologicFemaleHepatectomyHumansConceptsCaroli syndromePartial hepatectomyBiliary tract surgeryAbdominal CT scanBest current treatmentIntrahepatic bile ductsPercutaneous cholangiographyPersistent feverSurgical drainageAbdominal abscessBile ductClinical evidenceCystic dilatationRare entityTherapeutic choiceCurrent treatmentCT scanPrevious historyPatientsSyndromeHepatectomyDiseaseCholangiographyAbscessSurgery
1989
Hepatic fibropolycystic disease in Mexico. Study of 82 cases.
Torres-Barrera G, García-Tsao G, Quiroz F, Ferrari. Hepatic fibropolycystic disease in Mexico. Study of 82 cases. Revista De Investigación Clínica 1989, 41: 45-52. PMID: 2727432.Peer-Reviewed Original ResearchConceptsCongenital hepatic fibrosisFibropolycystic diseaseLiver function testsPolycystic liver diseaseHepatic fibrosisCholedochal cystCaroli's diseaseLiver diseaseFunction testsMean agePolycystic kidneysInstituto Nacional de la NutriciónRenal insufficiencyVariceal hemorrhageSalvador ZubiránPolycystic diseaseIsolated diseaseIndividual patientsLarge seriesFibrosisCholangitisDiseasePatientsCystsKidney
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