2025
Sulopenem versus Amoxicillin/Clavulanate for the Treatment of Uncomplicated Urinary Tract Infection.
Puttagunta S, Aronin S, Gupta J, Das A, Gupta K, Dunne M. Sulopenem versus Amoxicillin/Clavulanate for the Treatment of Uncomplicated Urinary Tract Infection. NEJM Evidence 2025, 4: evidoa2400414. PMID: 40552968, DOI: 10.1056/evidoa2400414.Peer-Reviewed Original ResearchConceptsUrinary tract infectionUncomplicated urinary tract infectionsIntent-to-treat populationSusceptible to amoxicillin/clavulanateTract infectionsUrine cultureAdverse eventsTreatment of uncomplicated urinary tract infectionsCombined population of patientsPatients treated with amoxicillin/clavulanateTreatment-emergent adverse eventsBaseline urine culturePositive urine cultureMild adverse eventsPopulation of patientsTreatment of adult womenClasses of antibioticsMicrobiological eradicationBaseline pathogensClinical cureDouble-blindMedian ageTrial medicationAmoxicillin/clavulanateAntimicrobial resistance
2022
Assessment of the Frequency, Phenotypes, and Outcomes of Acute Liver Injury Associated with Amoxicillin/Clavulanate in 1.4 Million Patients in the Veterans Health Administration
Suzuki A, Tillmann H, Williams J, Hauser R, Frund J, Suzuki M, Prior F, Aithal G, Lucena M, Andrade R, Tong W, Hunt C. Assessment of the Frequency, Phenotypes, and Outcomes of Acute Liver Injury Associated with Amoxicillin/Clavulanate in 1.4 Million Patients in the Veterans Health Administration. Drug Safety 2022, 46: 129-143. PMID: 36547811, DOI: 10.1007/s40264-022-01255-3.Peer-Reviewed Original ResearchConceptsPre-existing liver conditionsAcute liver injuryAmoxicillin/clavulanateDrug-induced liver injuryLiver injuryLiver conditionsElectronic health record systemsHealth record systemsSignificant drug-induced liver injuryAcute Liver Injury AssociatedLiver Injury AssociatedOverall mortality riskGeneral patient populationVeterans Health AdministrationAlkaline phosphatase elevationSignificant health issueRecord systemLarge electronic health record datasetsElectronic health record datasetBilirubin elevationCholestatic injuryInpatient exposureInjury AssociatedLarge electronic health record systemHepatocellular injury
2008
Comparison of the effect of benzathine penicillin G, clarithromycin, cefprozil and amoxicillin/clavulanate on the bacteriological response and throat flora in group A beta hemolytic streptococcal tonsillopharyngitis.
Yildirim I, Ceyhan M, Gür D, Kaymakoğlu I. Comparison of the effect of benzathine penicillin G, clarithromycin, cefprozil and amoxicillin/clavulanate on the bacteriological response and throat flora in group A beta hemolytic streptococcal tonsillopharyngitis. The Turkish Journal Of Pediatrics 2008, 50: 120-5. PMID: 18664074.Peer-Reviewed Original ResearchConceptsAlpha-hemolytic streptococciBeta-lactamase productionBeta-hemolytic streptococcal tonsillopharyngitisBenzathine penicillin GStreptococcal tonsillopharyngitisInhibitory effectBacteriological cure rateEffect of clarithromycinAmoxicillin/clavulanatePenicillin GYears of ageProminent inhibitory effectAnaerobic bacteriaBacteriological responseCefprozil groupClarithromycin groupGABHS eradicationGABHS tonsillopharyngitisOral clarithromycinPharyngeal microfloraAmoxicillin/Lactamase productionThroat swabsCure rateThroat flora
2007
Mycophenolate mofetil for drug-induced vanishing bile duct syndrome.
Jakab SS, West AB, Meighan DM, Brown RS, Hale WB. Mycophenolate mofetil for drug-induced vanishing bile duct syndrome. World Journal Of Gastroenterology 2007, 13: 6087-9. PMID: 18023105, PMCID: PMC4250896, DOI: 10.3748/wjg.v13.45.6087.Peer-Reviewed Original ResearchConceptsBile duct syndromeAmoxicillin/clavulanateMycophenolate mofetilLow-dose mycophenolate mofetilSequential liver biopsiesInosine monophosphate dehydrogenase inhibitorSustained remissionCholestatic patternImmunosuppressive therapyElderly patientsProlonged cholestasisLiver biopsyLiver injuryMofetilPatientsComplete withdrawalAzathioprineSyndromeClavulanateDehydrogenase inhibitorCirrhosisCorticosteroidsPrednisoneRemissionCholestasis
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