2025
Identification of medication–microbiome interactions that affect gut infection
Kumar A, Sun R, Habib B, Deng T, Bencivenga-Barry N, Palm N, Ivanov I, Tamblyn R, Goodman A. Identification of medication–microbiome interactions that affect gut infection. Nature 2025, 644: 506-515. PMID: 40670788, DOI: 10.1038/s41586-025-09273-8.Peer-Reviewed Original ResearchConceptsEnterica serovar TyphimuriumSalmonella enterica subspRisk of infectionEffect of digoxin treatmentSerovar TyphimuriumS. TmGut microbiomeMicrobiome compositionRisk of gastrointestinal infectionsInvading pathogensMicrobiomeCardiac glycoside digoxinNon-antibioticGut infectionImmune surveillanceDigoxin treatmentGastrointestinal infectionsB-defensinsGutInfectionEpidemiological studiesPopulation cohortDrugExperimental approachRisk
2019
Keratinocyte-derived CCL20 orchestrates epidermal localization of IL-17-producing γδ T cells and ILCs to mediate psoriasis-like skin inflammation
Singh T, Lu X, Singh S, Zhang H, Doucet M, Kominsky S, Farber J. Keratinocyte-derived CCL20 orchestrates epidermal localization of IL-17-producing γδ T cells and ILCs to mediate psoriasis-like skin inflammation. The Journal Of Immunology 2019, 202: 183.21-183.21. DOI: 10.4049/jimmunol.202.supp.183.21.Peer-Reviewed Original ResearchIL-17-producingT cellsKnock-In MiceIL-17Psoriasis-like skin inflammationGd T cellsExpression of CCL20Expression of IL17Hair folliclesCCR6 ligandIMQ treatmentPsoriatic dermatitisCCR6IL-22Skin inflammationReduce inflammationCCL20Day 4Treated skinInflammationMiceB-defensinsSuperficial epidermisKeratinocytesIMQ
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