2025
Case Report: jaundice in the young: the complexity of rare diseases beyond cholangiopathies
Guglielmo S, Pasin F, Biolo M, Mescoli C, Vio S, Fabris L, Simioni P. Case Report: jaundice in the young: the complexity of rare diseases beyond cholangiopathies. Frontiers In Gastroenterology 2025, 4: 1579928. DOI: 10.3389/fgstr.2025.1579928.Peer-Reviewed Original ResearchAutoimmune hemolytic anemiaInflammatory bowel diseaseSerum IgG4 levelsAutoimmune pancreatitisCorticosteroid therapyIgG4 levelsClinical presentationAssociated with elevated serum IgG4 levelsDiagnosis of type 2 AIPComplication of autoimmune pancreatitisSuspicion of autoimmune pancreatitisElevated serum IgG4 levelsRemission of jaundiceType 2 AIPAssociated with inflammatory bowel diseaseBile duct dilatationPositive Coombs testDiagnosis of Crohn's diseaseMild weight lossPancreato-biliary diseasesPresentation of diseasePale stoolsAbdominal painClinical responseUnnecessary surgery
2023
Appearance of tolerance-induction and non-inflammatory SARS-CoV-2 spike-specific IgG4 antibodies after COVID-19 booster vaccinations
Akhtar M, Islam M, Khaton F, Soltana U, Jafrin S, Rahman S, Tauheed I, Ahmed T, Khan I, Akter A, Khan Z, Islam M, Khanam F, Biswas P, Ahmmed F, Ahmed S, Rashid M, Hossain M, Alam A, Alamgir A, Rahman M, Ryan E, Harris J, LaRocque R, Flora M, Chowdhury F, Khan A, Banu S, Shirin T, Bhuiyan T, Qadri F. Appearance of tolerance-induction and non-inflammatory SARS-CoV-2 spike-specific IgG4 antibodies after COVID-19 booster vaccinations. Frontiers In Immunology 2023, 14: 1309997. PMID: 38173725, PMCID: PMC10763240, DOI: 10.3389/fimmu.2023.1309997.Peer-Reviewed Original ResearchConceptsFuture vaccination strategiesIgG responsesVaccination strategiesVaccine typesImmunological toleranceImmune responseMRNA dosesSpecific IgG antibody responseIgG subclass analysisRobust IgG responseChAdOx1 nCoV-19IgG antibody responsePrimary IgG responseSARS-CoV-2 variantsHumoral immune responseMRNA vaccine dosesCOVID-19 vaccinationNumber of dosesSARS-CoV-2 spike receptorBooster dosesBooster vaccinationIgG4 levelsIgG4 responsesMRNA vaccinationIgG levels
2020
Serum IgG4 Subclass Deficiency Defines a Distinct, Commonly Encountered, Severe Inflammatory Bowel Disease Subtype
Koutroumpakis F, Phillips AE, Yadav D, Machicado JD, Ahsan M, Rivers C, Tan X, Schwartz M, Proksell S, Johnston E, Dueker J, Hashash JG, Barrie A, Harrison J, Dunn MA, Konnikova L, Hartman DJ, Din H, Babichenko D, Tang G, Binion DG. Serum IgG4 Subclass Deficiency Defines a Distinct, Commonly Encountered, Severe Inflammatory Bowel Disease Subtype. Inflammatory Bowel Diseases 2020, 27: 855-863. PMID: 32879976, DOI: 10.1093/ibd/izaa230.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseIgG4 subclass deficiencyIgG4 levelsSubclass deficiencyAntibody deficiencyIgG4 deficiencyDisease severitySevere inflammatory bowel diseaseHigh serum IgG4 levelsInflammatory bowel disease subtypeCD-related surgeryIg replacement therapyLow IgG4 levelsMultiple Poisson regression analysisMore hospital admissionsPrimary sclerosing cholangitisSerum IgG4 levelsCohort of patientsIgG4 serum levelsOutpatient antibiotic prescriptionsAnti-inflammatory moleculesHumoral immune responseInflammatory disease processesPoisson regression analysisElectronic health records
2015
IgG4‐related tubulointerstitial nephritis: A prospective analysis
Nada R, Ramachandran R, Kumar A, Rathi M, Rawat A, Joshi K, Kohli H, Gupta K. IgG4‐related tubulointerstitial nephritis: A prospective analysis. International Journal Of Rheumatic Diseases 2015, 19: 721-729. PMID: 26355389, DOI: 10.1111/1756-185x.12675.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAutoimmune DiseasesBiomarkersBiopsyDisease ProgressionFemaleFollow-Up StudiesGlomerulonephritis, MembranousHumansImmunoglobulin GImmunohistochemistryImmunosuppressive AgentsIndiaKidneyKidney Failure, ChronicMaleMiddle AgedNephritis, InterstitialProspective StudiesProteinuriaRemission InductionTime FactorsTreatment OutcomeYoung AdultConceptsEnd stage renal diseaseStage renal diseaseRenal diseaseFollow-upSteroid therapyRenal dysfunctionExtra-renal organ involvementIgG4-related systemic diseaseSerum IgG4 levelsProgressive chronic kidney diseaseEnd-stage renal diseaseExtra-renal manifestationsFocal renal massesProgressive renal failurePattern CTubulo-interstitial nephritisProspective Follow-upChronic kidney diseaseImmunosuppressive therapyAggressive courseIgG4 levelsHistological diagnosisRenal massesSerum creatinineOrgan involvement
2013
IgG 4-RSD involving the pleura (P3373)
Kohli R, Chowdhary H. IgG 4-RSD involving the pleura (P3373). The Journal Of Immunology 2013, 190: 202.9-202.9. DOI: 10.4049/jimmunol.190.supp.202.9.Peer-Reviewed Original ResearchPlasma cellsHand swellingIgG4 levelsPleural effusionPleural biopsyIgG4-positive plasma cellsSignificant past medical historyEvidence of synovitisHigh IgG4 levelsPleural fluid aspirationSerum IgG4 levelsPast medical historyPositive plasma cellsOld Caucasian femaleNovel clinical entityRange of motionClinical significant improvementIgG4-RLDIgG4-RSDOccasional dyspneaSteroid therapyLeft lungRoutine bloodClinical entityImmunological markers
2011
Pitfalls in avoiding operation for autoimmune pancreatitis
Learn P, Grossman E, K.G. R, Allen P, Brennan M, D’Angelica M, DeMatteo R, Fong Y, Klimstra D, Schattner M, Jarnagin W. Pitfalls in avoiding operation for autoimmune pancreatitis. Surgery 2011, 150: 968-974. PMID: 21893326, DOI: 10.1016/j.surg.2011.06.015.Peer-Reviewed Original ResearchConceptsAutoimmune pancreatitisPretreatment fine-needle aspirationDiagnosis of autoimmune pancreatitisInaccurate preoperative diagnosisAdequate clinical dataPostoperative disease recurrenceRecurrence of diseaseFine-needle aspirationDisease recurrenceIgG4 levelsOperative procedurePancreatic resectionPreoperative diagnosisPretreatment imagingClinical courseInitial presentationInstitutional cohortNeedle aspirationInitial treatmentPancreatic enlargementClinical dataCytologic evaluationOperative interventionPancreatitisClinical characterization
2010
Use of immunohistochemistry for IgG4 in the distinction of autoimmune pancreatitis from peritumoral pancreatitis
Dhall D, Suriawinata A, Tang L, Shia J, Klimstra D. Use of immunohistochemistry for IgG4 in the distinction of autoimmune pancreatitis from peritumoral pancreatitis. Human Pathology 2010, 41: 643-652. PMID: 20149413, DOI: 10.1016/j.humpath.2009.10.019.Peer-Reviewed Original ResearchConceptsSerum IgG4 levelsIgG4-positive cellsAutoimmune pancreatitisPeritumoral pancreatitisIgG4 levelsIgG4 stainingEpithelial lesionsPancreatitis casesPancreatic cancerElevated serum IgG4 levelsCase of autoimmune pancreatitisDiagnosing autoimmune pancreatitisDense stainingPancreatic head massGranulocytic epithelial lesionsPositive plasma cellsAreas of acute inflammationUsefulness of immunohistochemistryPancreatic ductal adenocarcinomaIgG4 immunohistochemistryPancreatic resectionSclerosing pancreatitisPancreatic adenocarcinomaPancreatic massDiagnostic dilemma
2004
Lymphoplasmacytic sclerosing (autoimmune) pancreatitis
Klimstra D, Adsay N. Lymphoplasmacytic sclerosing (autoimmune) pancreatitis. Seminars In Diagnostic Pathology 2004, 21: 237-246. PMID: 16273942, DOI: 10.1053/j.semdp.2005.07.004.Peer-Reviewed Original ResearchConceptsLymphoplasmacytic sclerosing pancreatitisPancreatic carcinomaFibroinflammatory lesionsChronic pancreatitisAutoimmune diseasesDuct-destructive chronic pancreatitisElevated serum IgG4 levelsResponse to steroid therapyAssociated with other autoimmune diseasesManifestations of autoimmune diseasePeriductal lymphoplasmacytic inflammationSerum IgG4 levelsBile duct strictureCases of lymphoplasmacytic sclerosing pancreatitisMiddle-aged patientsTumor-like massHistologically distinct typesPreoperative diagnostic testsObliterative venulitisSteroid therapySurgical resectionBiliary involvementIgG4 levelsResected casesDuct strictures
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