Development of a Goal Attainment Scale (GAS) outcome measure for clinical interventional studies in paediatric autism.
Staunton H, McIver T, Tillmann J, Clinch S, Hanrahan V, Ewens B, Averius C, Barsdorf A, Baranger A, Berry Kravis E, Charman T, Neerland H, Singer A, Ventola P, Jk Williams Z, Barrett L. Development of a Goal Attainment Scale (GAS) outcome measure for clinical interventional studies in paediatric autism. Autism 2025, 13623613251349904. PMID: 40559513, DOI: 10.1177/13623613251349904.Peer-Reviewed Original ResearchGoal Attainment ScalingGoal Attainment Scaling measurePersonalised goalsClinical outcome assessmentsDebriefing interviewsOutcome measuresOutcome assessmentCognitive debriefing interviewsConcept elicitation interviewsMethodologically robust approachOpen-ended questionsOutcome measurement strategyClinical researchHealth professionalsStandardised outcomesAutistic childrenAutistic peopleMeasure treatment effectsIntervention studiesQualitative interviewsClinical intervention studiesElicitation interviewsIndividual experienceTreatment effectsCharacteristics of autistic childrenSorafenib Alters Interstitial Proton and Sodium Levels in the Tumor Microenvironment: A 1H/23Na Spectroscopic Imaging Study
Khan M, Walsh J, Kurdi S, Mishra S, Mihailović J, Coman D, Hyder F. Sorafenib Alters Interstitial Proton and Sodium Levels in the Tumor Microenvironment: A 1H/23Na Spectroscopic Imaging Study. NMR In Biomedicine 2025, 38: e5319. PMID: 39764672, DOI: 10.1002/nbm.5319.Peer-Reviewed Original ResearchConceptsU87 tumorsSorafenib-treated tumorsUpregulated aerobic glycolysisSodium-potassium pumpInterstitial spaceTumor microenvironmentIntracellular NaTumor growthSpectroscopic imaging studiesTumor invasionGlioblastoma modelSodium levelsTumorGlioblastoma therapyImaging studiesPlaceboSorafenibMetabolic changesImmune functionCancer hallmarksAerobic glycolysisProliferative stateMeasure treatment effectsIonic changesProliferation rate
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