2025
Pregnenolone reduces provoked craving and cocaine use in men and women with cocaine use disorder: A pilot trial
Sakmar E, Wemm S, Fogelman N, Hermes G, Sinha R, Milivojevic V. Pregnenolone reduces provoked craving and cocaine use in men and women with cocaine use disorder: A pilot trial. Drug And Alcohol Dependence 2025, 274: 112765. PMID: 40570771, DOI: 10.1016/j.drugalcdep.2025.112765.Peer-Reviewed Original ResearchCocaine use disorderCocaine useNeuroactive steroidsUse disorderTreatment of cocaine use disorderCocaine use outcomePregnenolone levelsTreatment-seeking individualsDays of cocaineChronic cocaine useExposure to stressPreg groupCocaine cuesCocaine cravingCraving responsesNeutral cuesInduce cravingCravingWeek 2CocaineChronic treatmentPilot findingsCocaine amountPrecursor pregnenoloneLinear mixed effects models
2024
Brain correlates and functional connectivity linking stress, autonomic dysregulation, and alcohol motivation
Seo D, Martins J, Sinha R. Brain correlates and functional connectivity linking stress, autonomic dysregulation, and alcohol motivation. Neurobiology Of Stress 2024, 31: 100645. PMID: 38933283, PMCID: PMC11201348, DOI: 10.1016/j.ynstr.2024.100645.Peer-Reviewed Original ResearchAutonomic nervous system disruptionAlcohol use disorderFunctional magnetic resonance imagingHigh-risk drinkingSocial drinkersFunctional connectivityLow-risk drinkingAlcohol motivationAutonomic arousalDevelopment of alcohol use disordersNeural correlates of stressNon-dependent social drinkersWhole-brain correlation analysesResponse to stress exposureAlcohol taste testFrontal-striatal regionsStress-induced cravingVentromedial prefrontal cortexBehaviors associated with stressAnterior cingulate cortexDecreased functional connectivityExposure to stressAutonomic nervous systemAlcohol intakeHazardous alcohol useEvidence that personalized racial stress procedures elicit a stress response and increases alcohol craving among Black adults with alcohol use disorder: A laboratory pilot study
Haeny A, Schick M, McKenley C, Chowdhary A, Bellamy C, O'Malley S, Sinha R. Evidence that personalized racial stress procedures elicit a stress response and increases alcohol craving among Black adults with alcohol use disorder: A laboratory pilot study. Drug And Alcohol Dependence 2024, 260: 111312. PMID: 38749311, PMCID: PMC11991899, DOI: 10.1016/j.drugalcdep.2024.111312.Peer-Reviewed Original ResearchAlcohol use disorderAlcohol cravingIncreased alcohol cravingUse disorderRacial stressEmotional responsesImpact of racial stressBlack adultsExposure to stressStress scriptsImagery procedureExposure sessionsCravingPersonal eventsStress procedureNegative emotionsNeutral conditionsPositive emotionsIdentity explorationStress responseExploratory analysisPhysiological responsesSessionsEmotionsAlcohol
2023
Impact of Stress Exposure on Mental and Physical Health across the Life Span: Molecular mechanisms, Neurobiological abnormalities, and Novel Pathways for Intervention
Cattaneo A, Anacker C, Daskalakis N, Riva M. Impact of Stress Exposure on Mental and Physical Health across the Life Span: Molecular mechanisms, Neurobiological abnormalities, and Novel Pathways for Intervention. Psychoneuroendocrinology 2023, 153: 106142. DOI: 10.1016/j.psyneuen.2023.106142.Peer-Reviewed Original ResearchStress exposureEffects of stress exposureImpact of stress exposureSensorimotor gating deficitsChildhood trauma survivorsNegative outcomesPhysical healthEarly life adversityNegative effects of stressExposure to adversityExposure to stressEffects of stressGating deficitsNeurobiological abnormalitiesNeurobiological mechanismsLife stressLife adversityTrauma survivorsSerotonin SignalingAffective behaviorNeurodevelopmental windowBrain functionAt adulthoodPhysical diseaseMouse hippocampus
2017
Cross‐tissue telomere length measurement to determine auxiliary marker of brain telomere length in neurosurgery patients
Lussier S, Braun P, Potash J, Shinozaki G, Stevens H. Cross‐tissue telomere length measurement to determine auxiliary marker of brain telomere length in neurosurgery patients. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.lb60.Peer-Reviewed Original ResearchCentral nervous systemBlood telomere lengthCentral nervous system measuresNeurosurgery patientsTelomere lengthTelomere length measurementAcute time courseExposure to glucocorticoidsCoronary artery diseasePost-surgery samplesRisk of strokeResection surgeryArtery diseaseSynthetic glucocorticoidSamples of bloodLength measurementsExposure to stressRemoved tissueHeart diseaseHuman studiesAverage agePatientsPeripheral tissuesSurgeryPeripheral measures
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