2019
Factors Associated with Utilization of 17-Hydroxyprogesterone Caproate for the Prevention of Recurrent Preterm Birth
DeNoble AE, Wynn CE, Weaver KE, Wheeler SM, Swamy GK. Factors Associated with Utilization of 17-Hydroxyprogesterone Caproate for the Prevention of Recurrent Preterm Birth. American Journal Of Perinatology 2019, 37: 264-270. PMID: 30708392, DOI: 10.1055/s-0039-1678532.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPrior term birthPrenatal care initiationEligible womenPreterm birthPrimary outcomeTerm birthsWeeks' gestationCare initiationHispanic ethnicityRecurrent spontaneous preterm birthSingleton spontaneous preterm birthPrior spontaneous preterm birthRecurrent preterm birthRetrospective cohort studyAcademic health systemStepwise logistic regressionSPTB rateCohort studyEligible subjectsSingleton pregnanciesClinical predictorsPoor adherenceMaternal ageCare barriers
2017
Pharmacogenomics of 17‐alpha hydroxyprogesterone caproate for recurrent preterm birth: a case–control study
Manuck T, Watkins W, Esplin, Biggio J, Bukowski R, Parry S, Zhan H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy U, Ilekis J, Yandell M, Varner M, Jorde L, Research T. Pharmacogenomics of 17‐alpha hydroxyprogesterone caproate for recurrent preterm birth: a case–control study. BJOG An International Journal Of Obstetrics & Gynaecology 2017, 125: 343-350. PMID: 28139890, DOI: 10.1111/1471-0528.14485.Peer-Reviewed Original ResearchConceptsRecurrent preterm birthPreterm birthSuccessful prolongationDefinition ADefinition BSingleton spontaneous preterm birthSpontaneous preterm birthTertiary care centerCase-control studyWhole-exome sequencingUntreated pregnanciesGestational ageHydroxyprogesterone caproateSignificant prolongationPregnancyExome sequencingProlongationWomenPharmacogenetic genesBirthGene ontology pathwaysIntegrated DiscoveryOntology pathwaysNovel analytic approach
2015
Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth
Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J, Research E. Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth. American Journal Of Obstetrics And Gynecology 2015, 214: 376.e1-376.e8. PMID: 26692181, PMCID: PMC4803498, DOI: 10.1016/j.ajog.2015.12.010.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPrevious spontaneous preterm birthRecurrent spontaneous preterm birthDelivery gestational ageRecurrent preterm birthPreterm birthSimilar gestational ageGestational ageHydroxyprogesterone caproateSingleton spontaneous preterm birthEarly spontaneous preterm birthFirst-degree family historyPreterm birth preventionHigh-risk womenPlanned secondary analysisPredictors of responseChi-square testPenultimate pregnancyPregnancy characteristicsNeonatal morbidityPregnancy coursePreterm pregnanciesBirth preventionCurrent pregnancyRegression modelsThe phenotype of spontaneous preterm birth: application of a clinical phenotyping tool
Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J, Research E. The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool. American Journal Of Obstetrics And Gynecology 2015, 212: 487.e1-487.e11. PMID: 25687564, PMCID: PMC4456184, DOI: 10.1016/j.ajog.2015.02.010.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthEarly spontaneous preterm birthInfection/inflammationDecidual hemorrhageGestational ageCervical insufficiencyPreterm birthWeeks' gestationPlacental dysfunctionWhite womenMaternal stressSingleton spontaneous preterm birthDelivery gestational ageFinal common pathwayAfrican American womenMaternal comorbiditiesPremature ruptureProspective studyPlanned analysisUterine distentionClinical dataMultiple possible causesGestationHemorrhageComprehensive classification system
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