2025
Targeting FKBP51 prevents stress-induced preterm birth
Guzeloglu-Kayisli O, Ozmen A, Un B, Un B, Blas J, Johnson I, Thurman A, Walters M, Friend D, Kayisli U, Lockwood C. Targeting FKBP51 prevents stress-induced preterm birth. EMBO Molecular Medicine 2025, 17: 775-796. PMID: 40097636, PMCID: PMC11982339, DOI: 10.1038/s44321-025-00211-9.Peer-Reviewed Original ResearchConceptsDecidual stromal cellsPreterm birthProgesterone receptorFKBP51 levelsIdiopathic preterm birthPrevent preterm birthMaternal-fetal interfaceFDA-approved therapiesExpression of FKBP5Activity of glucocorticoidsPerinatal morbidityShortened gestationPR receptorsInitiate laborTranscriptional activity of glucocorticoidProlonged gestationStress-related disordersTherapeutic strategiesStromal cellsInhibit transcriptional activationCo-treatmentPTGS2 levelsMaternal stressGestationFKBP51
2011
9: Calcifying nanoparticles (NP) as novel etiologic agents of idiopathic preterm birth (iPTB) and preterm premature rupture of the membranes (PPROM)
Shook L, Buhimschi C, Dulay A, Zhao G, Ali U, Han C, Campbell K, Werner E, Buhimschi I. 9: Calcifying nanoparticles (NP) as novel etiologic agents of idiopathic preterm birth (iPTB) and preterm premature rupture of the membranes (PPROM). American Journal Of Obstetrics And Gynecology 2011, 204: s7. DOI: 10.1016/j.ajog.2010.10.016.Peer-Reviewed Original Research
2008
Multidimensional Proteomics Analysis of Amniotic Fluid to Provide Insight into the Mechanisms of Idiopathic Preterm Birth
Buhimschi IA, Zhao G, Rosenberg VA, Abdel-Razeq S, Thung S, Buhimschi CS. Multidimensional Proteomics Analysis of Amniotic Fluid to Provide Insight into the Mechanisms of Idiopathic Preterm Birth. PLOS ONE 2008, 3: e2049. PMID: 18431506, PMCID: PMC2315798, DOI: 10.1371/journal.pone.0002049.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniotic FluidBiomarkersDown-RegulationElectrophoresis, Gel, Two-DimensionalFemaleHemorrhageHumansInflammationPlacentaPregnancyPregnancy ProteinsPremature BirthProteomeProteomicsRNA, MessengerSoftwareSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationTreatment OutcomeUmbilical CordUp-RegulationConceptsPreterm birthAmniotic fluidIdiopathic preterm birthIntra-amniotic inflammationMost preterm birthsSubgroup of patientsAbsence of inflammationDistinct pathogenetic mechanismsFuture drug developmentProteomic fingerprintExpectant managementNovel pathogenetic pathwaysPreterm laborPremature ruptureClinical resultsPathogenetic mechanismsPathogenetic pathwaysConsecutive sampleTherapeutical interventionsInflammationSELDI peaksBirthBleedingProtein metabolismDrug development
2006
Proteomics analysis of amniotic fluid. A novel methodology to provide insight into the mechanisms of idiopathic preterm birth
Buhimschi I, Rosenberg V, Abdel-Razeq S, Thung S, Buhimschi C. Proteomics analysis of amniotic fluid. A novel methodology to provide insight into the mechanisms of idiopathic preterm birth. American Journal Of Obstetrics And Gynecology 2006, 195: s6. DOI: 10.1016/j.ajog.2006.10.018.Peer-Reviewed Original ResearchIdiopathic preterm birthPreterm birth
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