2021
Thick Fibrous Septa on Liver Biopsy Specimens Predict the Development of Decompensation in Patients With Compensated Cirrhosis
Jain D, Sreenivasan P, Inayat I, Deng Y, Ciarleglio MM, Garcia-Tsao G. Thick Fibrous Septa on Liver Biopsy Specimens Predict the Development of Decompensation in Patients With Compensated Cirrhosis. American Journal Of Clinical Pathology 2021, 156: 802-809. PMID: 33940622, PMCID: PMC8512277, DOI: 10.1093/ajcp/aqab024.Peer-Reviewed Original ResearchConceptsDevelopment of decompensationThick fibrous septaSeptal widthCompensated cirrhosisClinical decompensationSeptal thicknessFibrous septaEnd-stage liver disease (MELD) scorePrimary end pointSignificant portal hypertensionLiver Disease scoreLiver biopsy specimenLiver biopsy specimensNodule sizeCirrhosis decompensationHistologic cirrhosisCompensated patientsPortal hypertensionIndependent predictorsLiver biopsyCommon etiologyWorse prognosisBiopsy specimenBiopsy specimensUnivariate analysis
2015
How Do Liquid-Based Preparations of Thyroid Fine-Needle Aspiration Compare with Conventional Smears? An Analysis of 5475 Specimens
Nagarajan N, Schneider EB, Ali SZ, Zeiger MA, Olson MT. How Do Liquid-Based Preparations of Thyroid Fine-Needle Aspiration Compare with Conventional Smears? An Analysis of 5475 Specimens. Thyroid 2015, 25: 308-313. PMID: 25420135, DOI: 10.1089/thy.2014.0394.Peer-Reviewed Original ResearchConceptsFine-needle aspirationLiquid-based preparationsLBP casesConventional smearsBenign diagnosisThyroid nodulesMalignant diagnosisHistology diagnosisAspirated materialClinical databaseSuspicious categoryCS casesInitial evaluationInadequate samplesDiagnosisNodule sizePatientsSecond reviewDiagnostic frequencySmearsInadequate rateHigher proportionLower proportionPivotal roleNodules
2013
Cirrhosis Regression and Subclassification
Bedossa P, Garcia-Tsao G, Jain D. Cirrhosis Regression and Subclassification. Surgical Pathology Clinics 2013, 6: 295-309. PMID: 26838976, DOI: 10.1016/j.path.2013.03.006.Peer-Reviewed Original ResearchFibrosis areaSeptal widthChronic liver diseaseNodule sizeCirrhosis regressionPortal hypertensionUnderlying diseaseHemodynamic consequencesLiver diseaseLiver fibrosisSuccessful treatmentVascular remodelingDisease severityCirrhosisEnd pointFibrosisDiseaseProgressionClassification systemHypertensionDecompensationSubclassification
2012
Quantitative histological‐hemodynamic correlations in cirrhosis
Sethasine S, Jain D, Groszmann RJ, Garcia‐Tsao G. Quantitative histological‐hemodynamic correlations in cirrhosis. Hepatology 2012, 55: 1146-1153. PMID: 22109744, PMCID: PMC3721182, DOI: 10.1002/hep.24805.Peer-Reviewed Original ResearchConceptsSignificant portal hypertensionPortal hypertensionFibrosis areaLiver biopsyCirrhotic nodulesNodule sizeHVPG measurementPortal pressureIndependent predictorsSeptal thicknessFibrous septaBiopsyPathophysiological implicationsCirrhosisHVPGPatientsSemiquantitative analysisNodulesOnly parameterHypertensionNumber of nodules
2009
Computer-aided detection for the identification of pulmonary nodules in pediatric oncology patients: initial experience
Helm EJ, Silva CT, Roberts HC, Manson D, Seed MT, Amaral JG, Babyn PS. Computer-aided detection for the identification of pulmonary nodules in pediatric oncology patients: initial experience. Pediatric Radiology 2009, 39: 685-693. PMID: 19418048, DOI: 10.1007/s00247-009-1259-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlgorithmsArtificial IntelligenceChildChild, PreschoolFemaleHumansLung NeoplasmsMaleObserver VariationPattern Recognition, AutomatedPilot ProjectsRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySolitary Pulmonary NoduleTomography, X-Ray ComputedConceptsPediatric oncology patientsPulmonary nodulesSensitivity of CADOncology patientsPediatric patientsPrimary tumorIRB approvalPediatric radiologistsMethodsCT scansInitial experiencePatientsLung nodulesNodule sizeNodulesAvailable CAD systemPerformance of CADRadiologistsComputer-aided detectionInitial findingsLow numberRadiologists' sensitivityObjectiveToTumorsSensitivity
2005
Histological-hemodynamic correlation in cirrhosis—a histological classification of the severity of cirrhosis
Nagula S, Jain D, Groszmann RJ, Garcia-Tsao G. Histological-hemodynamic correlation in cirrhosis—a histological classification of the severity of cirrhosis. Journal Of Hepatology 2005, 44: 111-117. PMID: 16274836, DOI: 10.1016/j.jhep.2005.07.036.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientPresence of CSPHSeverity of cirrhosisSeptal thicknessSmall nodularityPortal hypertensionPortal tractsBiopsy-proven cirrhosisSpecific histological parametersVenous pressure gradientDevelopment of complicationsNodule sizeHistological cirrhosisSinusoidal fibrosisAlcoholic etiologyHVPG measurementIndependent predictorsDefinitive diagnosisHistological classificationBACKGROUND/CirrhosisHistological parametersCentral veinNodularityCSPHRole of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatocellular carcinoma
Cillo U, Vitale A, Navaglia F, Basso D, Montin U, Bassanello M, D'Amico F, Ciarleglio F, Brolese A, Zanus G, De Pascale V, Plebani M, D'Amico D. Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatocellular carcinoma. World Journal Of Gastroenterology 2005, 11: 6920-6925. PMID: 16437593, PMCID: PMC4717031, DOI: 10.3748/wjg.v11.i44.6920.Peer-Reviewed Original ResearchConceptsTumor gradeHepatocellular carcinomaRadical therapyAFP mRNASurgical therapyMRNA statusPrognostic evaluation of HCC patientsAssessment of tumor gradePrognostic evaluation of patientsDiagnosis of hepatocellular carcinomaNodule sizeDetermination of tumor gradeEvaluation of HCC patientsPreoperative tumor gradeMedian Follow-UpPercutaneous ablative proceduresTumor-related variablesSignificant survival predictorsPotential prognostic roleCohort of patientsEvaluation of patientsSignificant prognosticatorsPrognostic rolePercutaneous biopsyPerformance status
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