Thick Fibrous Septa on Liver Biopsy Specimens Predict the Development of Decompensation in Patients With Compensated Cirrhosis
Jain D, Sreenivasan P, Inayat I, Deng Y, Ciarleglio MM, Garcia-Tsao G. Thick Fibrous Septa on Liver Biopsy Specimens Predict the Development of Decompensation in Patients With Compensated Cirrhosis. American Journal Of Clinical Pathology 2021, 156: 802-809. PMID: 33940622, PMCID: PMC8512277, DOI: 10.1093/ajcp/aqab024.Peer-Reviewed Original ResearchConceptsDevelopment of decompensationThick fibrous septaSeptal widthCompensated cirrhosisClinical decompensationSeptal thicknessFibrous septaEnd-stage liver disease (MELD) scorePrimary end pointSignificant portal hypertensionLiver Disease scoreLiver biopsy specimenLiver biopsy specimensNodule sizeCirrhosis decompensationHistologic cirrhosisCompensated patientsPortal hypertensionIndependent predictorsLiver biopsyCommon etiologyWorse prognosisBiopsy specimenBiopsy specimensUnivariate analysisSACRED: Effect of simvastatin on hepatic decompensation and death in subjects with high-risk compensated cirrhosis: Statins and Cirrhosis: Reducing Events of Decompensation
Kaplan D, Mehta R, Garcia-Tsao G, Albrecht J, Aytaman A, Baffy G, Bajaj J, Hernaez R, Hunt K, Ioannou G, Johnson K, Kanwal F, Lee T, Monto A, Pandya P, Schaubel D, Taddei T. SACRED: Effect of simvastatin on hepatic decompensation and death in subjects with high-risk compensated cirrhosis: Statins and Cirrhosis: Reducing Events of Decompensation. Contemporary Clinical Trials 2021, 104: 106367. PMID: 33771685, PMCID: PMC8422958, DOI: 10.1016/j.cct.2021.106367.Peer-Reviewed Original ResearchConceptsHepatic decompensationPortal hypertensionEvents of decompensationHepatic decompensation eventsLiver-related deathSignificant portal hypertensionAcceptable safety profileProspective human studiesRole of statinsChronic liver diseaseClasses of medicationsPatient-reported outcomesDevelopment of decompensationEffect of simvastatinVA Medical CenterCompensated cirrhosisDecompensation eventsStatin therapyVariceal hemorrhageCirrhotic patientsStandard therapyVascular reactivityExert pleiotropic effectsLiver diseaseRetrospective study
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply