2023
Health equity considerations in pragmatic trials in Alzheimer's and dementia disease: Results from a methodological review
Nicholls S, Al‐Jaishi A, Niznick H, Carroll K, Madani M, Peak K, Madani L, Nevins P, Adisso L, Li F, Weijer C, Mitchell S, Welch V, Quiñones A, Taljaard M. Health equity considerations in pragmatic trials in Alzheimer's and dementia disease: Results from a methodological review. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2023, 15: e12392. PMID: 36777091, PMCID: PMC9899766, DOI: 10.1002/dad2.12392.Peer-Reviewed Original Research
2022
Disentangling the genetic basis of rhizosphere microbiome assembly in tomato
Oyserman B, Flores S, Griffioen T, Pan X, van der Wijk E, Pronk L, Lokhorst W, Nurfikari A, Paulson J, Movassagh M, Stopnisek N, Kupczok A, Cordovez V, Carrión V, Ligterink W, Snoek B, Medema M, Raaijmakers J. Disentangling the genetic basis of rhizosphere microbiome assembly in tomato. Nature Communications 2022, 13: 3228. PMID: 35710629, PMCID: PMC9203511, DOI: 10.1038/s41467-022-30849-9.Peer-Reviewed Original ResearchConceptsMicrobiome assemblyGenetic basisRhizosphere microbiome assemblyMetagenome-assembled genomesGene content analysisQuantitative trait lociDomestication sweepsDomesticated tomatoRhizosphere microbiomePutative plantPlant geneticsTrait lociBacterial genesPlant growthHybrid populationsQuantitative traitsBreeding programsMbp regionGenetic variation associatesPlant polysaccharidesDifferential recruitmentTomatoStreptomycesTraitsPivotal role
2021
An Electrocortical Measure Associated With Metarepresentation Mediates the Relationship Between Autism Symptoms and Theory of Mind
Libsack E, Trimber E, Hauschild K, Hajcak G, McPartland J, Lerner M. An Electrocortical Measure Associated With Metarepresentation Mediates the Relationship Between Autism Symptoms and Theory of Mind. Clinical Psychological Science 2021, 10: 324-339. PMID: 38736986, PMCID: PMC11086972, DOI: 10.1177/21677026211021975.Peer-Reviewed Original ResearchLate positive complexTheory of mindMental state inferencesLate slow waveASD symptom severityAutism spectrum disorderToM reasoningToM performanceElectrocortical measuresAutism symptomsERP componentsIndividual differencesPositive complexASD symptomsLPC scoresNeural mechanismsSpectrum disorderSymptom severityMetarepresentationDifferential recruitmentMindSlow wavesIndividualsASDAdolescents
2011
Differential Recruitment of Methyl CpG‐Binding Domain Factors and DNA Methyltransferases by the Orphan Receptor Germ Cell Nuclear Factor Initiates the Repression and Silencing of Oct4
Gu P, Xu X, Le Menuet D, Chung A, Cooney AJ. Differential Recruitment of Methyl CpG‐Binding Domain Factors and DNA Methyltransferases by the Orphan Receptor Germ Cell Nuclear Factor Initiates the Repression and Silencing of Oct4. Stem Cells 2011, 29: 1041-1051. PMID: 21608077, PMCID: PMC3468724, DOI: 10.1002/stem.652.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell DifferentiationCell Line, TumorCpG IslandsDNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3ADNA-Binding ProteinsEmbryonic Stem CellsGene Expression Regulation, DevelopmentalGene Knockdown TechniquesMiceMolecular Sequence DataNuclear Receptor Subfamily 6, Group A, Member 1Octamer Transcription Factor-3Promoter Regions, GeneticProtein BindingTranscription FactorsConceptsGerm cell nuclear factorEmbryonic stem cellsOct4 promoterDNA methylationDNA methyltransferasesRepressive functionEpigenetic modificationsTranscription factorsProximal promoterDifferentiation of ESCsWild-type embryonic stem cellsDe novo DnmtsGene-specific repressionKey transcription factorDifferential recruitmentNuclear factorGCNF bindsESC differentiationPluripotency genesOct4 geneSomatic cellsMethyl-CpGCis elementsMBD3Gene expressionFinding subtypes of transcription factor motif pairs with distinct regulatory roles
Bais AS, Kaminski N, Benos PV. Finding subtypes of transcription factor motif pairs with distinct regulatory roles. Nucleic Acids Research 2011, 39: e76-e76. PMID: 21486752, PMCID: PMC3113591, DOI: 10.1093/nar/gkr205.Peer-Reviewed Original ResearchConceptsTF binding sitesTranscription factorsDownstream regulationMotif pairsTF-DNA binding specificityBinding preferencesDNA binding specificityDNA binding preferencesDistinct regulatory rolesDownstream regulatory effectsMultiple regulatory pathwaysDifferent binding preferencesDyad motifDNA sequencesSequence elementsRegulatory pathwaysBinding specificityRegulatory roleDifferential recruitmentBinding sitesMotif discoveryRegulationCofactorMotifDistinct modes
2007
Neural Dynamics of Rejection Sensitivity
Kross E, Egner T, Ochsner K, Hirsch J, Downey G. Neural Dynamics of Rejection Sensitivity. Journal Of Cognitive Neuroscience 2007, 19: 945-956. PMID: 17536965, DOI: 10.1162/jocn.2007.19.6.945.Peer-Reviewed Original ResearchConceptsRejection sensitivityCognitive controlRS individualsDorsal frontal regionsFunctional magnetic resonanceThemes of rejectionRejection stimuliAffective stimuliEmotional appraisalEmotional processingNegative valenceIndividual differencesPrefrontal structuresNeural dynamicsDistress ratingsFrontal regionsRepresentational paintingsBrain regionsR participantsStimuliPositive imageDifferential recruitmentIndividual responsesParticipantsInterest level
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